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Igj
Gene Detail
 Symbol
Name
ID
Igj
immunoglobulin joining chain
MGI:96493
Synonyms 9530090F24Rik, Jch, J chain
Feature Type protein coding gene
Genetic Map
Chromosome 5
43.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:88520512-88527891 bp, - strand
From VEGA annotation of GRCm38

  7380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16958  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Igj

Human
homologs
Human Homolog IGJ, immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
NCBI Gene ID 3512
neXtProt AC  NX_P01591
Human Synonyms  IGCJ, JCH
Human Chr (Location)  4q21; chr4:70655541-70676903 (-)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Chemically induced (ENU)(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show increased IgA level and alterations in IgA transport and in susceptibility to viral and parasitic infections. Homozygotes for another null allele show increased IgA level, decreased IgM level, reduced numbers of IgM plasma cells, and impaired IgM immune responses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process adaptive immune response, antibacterial humoral response, ...
Component blood microparticle, dimeric IgA immunoglobulin complex, ...
Function antigen binding, IgA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (11)   
Theiler Stages: 16, 21, 22, 24, 25, 26, 28
Assay TypeResults
Northern blot 22
Western blot 9
RT-PCR 8
cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(112) cDNA(110) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036864 (Evidence)
Ensembl Gene ModelENSMUSG00000067149 (Evidence)
Entrez Gene16069 (Evidence)
UniGene1192
DFCITC1576891, TC1685378
DoTSDT.493785, DT.523700
NIA Mouse Gene IndexU026370
Consensus CDS ProjectCCDS19401.1
International Mouse Knockout Project StatusIgj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036864 VEGA Gene Model | MGI Sequence Detail 7380 C57BL/6J ±  kb
transcript OTTMUST00000094695 VEGA | MGI Sequence Detail 1393 Not Applicable 
polypeptide OTTMUSP00000052718 VEGA | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024110 Immunoglobulin J chain
Protein Ontology PR:000008965 immunoglobulin J chain
References (Earliest) J:6713 Yagi M, et al., J chain is encoded by a single gene unlinked to other immunoglobulin structural genes. J Exp Med. 1982 Mar 1;155(3):647-54
(Latest) J:198540 Arai S, et al., Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep. 2013 Apr 25;3(4):1187-98
All references(51)
Other
accession IDs
MGD-MRK-11291, MGI:1915537, MGI:2140835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory