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Jchain
Gene Detail
Symbol

Name
ID
Jchain
immunoglobulin joining chain
MGI:96493
Synonyms
9530090F24Rik, Igj, Jch, J chain
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:88520512-88527891 bp, - strand
From VEGA annotation of GRCm38

  7380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16958  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: JCHAIN
Gene Tree: Jchain

Human
homologs
JCHAIN, joining chain of multimeric IgA and IgM
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3512
neXtProt AC: NX_P01591

Human Synonyms: IGCJ, IGJ, JCH

Human Chr (Location): 4q21; chr4:70655541-70676901 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show increased IgA level and alterations in IgA transport and in susceptibility to viral and parasitic infections. Homozygotes for another null allele show increased IgA level, decreased IgM level, reduced numbers of IgM plasma cells, and impaired IgM immune responses.
 
Interactions
Jchain interacts with 151 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process adaptive immune response, antibacterial humoral response, ...
Component blood microparticle, dimeric IgA immunoglobulin complex, ...
Function antigen binding, IgA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 22
Western blot 9
RT-PCR 8
cDNA source data(110)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(110) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036864 (Evidence)
Ensembl Gene Model ENSMUSG00000067149 (Evidence)
Entrez Gene 16069 (Evidence)
UniGene 1192
DFCI TC1576891, TC1685378
DoTS DT.493785, DT.523700
NIA Mouse Gene Index U026370
Consensus CDS Project CCDS19401.1
International Mouse Phenotyping Consortium Status Jchain
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036864 VEGA Gene Model | MGI Sequence Detail 7380 C57BL/6J ±  kb
transcript OTTMUST00000094695 VEGA | MGI Sequence Detail 1393 Not Applicable 
polypeptide OTTMUSP00000052718 VEGA | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024110 Immunoglobulin J chain
Protein Ontology PR:000008965 immunoglobulin J chain
References
(Earliest) J:6713 Yagi M, et al., J chain is encoded by a single gene unlinked to other immunoglobulin structural genes. J Exp Med. 1982 Mar 1;155(3):647-54
(Latest) J:198540 Arai S, et al., Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep. 2013 Apr 25;3(4):1187-98
All references(54)
Other
accession IDs
MGD-MRK-11291, MGI:1915537, MGI:2140835

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory