Igha
Gene Detail

Symbol Name ID

Igha immunoglobulin heavy constant alpha MGI:96444

Synonyms

IgA, Igh-2

Feature Type

gene segment

Genetic Map

Chromosome 12

62.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr12:113258768-113260236 bp, - strand From Ensembl annotation of GRCm38   1469 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Igha

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	humoral immune response mediated by circulating immunoglobulin, immunoglobulin mediated immune response, ...
Component	immunoglobulin complex, circulating
Function	antigen binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (3)
Theiler Stages: 28

Assay Type	Results
Immunohistochemistry	2

cDNA source data(1)
External Resources: Allen Institute  

Molecular reagents

All nucleic(36) Genomic(27) cDNA(8) Other(1)

Other database links

Ensembl Gene Model	ENSMUSG00000095079 (Evidence)
International Mouse Knockout Project Status	Igha

Sequences

Length	Strain/Species
genomic	ENSMUSG00000095079	Ensembl Gene Model | MGI Sequence Detail	1469	C57BL/6J
transcript	ENSMUST00000178282	Ensembl | MGI Sequence Detail	1034	Not Applicable
polypeptide	ENSMUSP00000137226	Ensembl | MGI Sequence Detail	344	Not Applicable

All sequences(3)

Polymorphisms

RFLP(4) : SNPs(0 from dbSNP Build 128)

References

(Earliest) J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
(Latest) J:187658 Khounlotham M, et al., Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis. Immunity. 2012 Sep 21;37(3):563-73
All references(74)

Other accession IDs

MGD-MRK-11241