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Igha
Gene Detail
 Symbol
Name
ID
Igha
immunoglobulin heavy constant alpha
MGI:96444
Synonyms IgA, Igh-2
Feature Type gene segment
Genetic Map
Chromosome 12
62.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr12:113258768-113260236 bp, - strand
From Ensembl annotation of GRCm38

  1469 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Gene Tree: Igha
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process humoral immune response mediated by circulating immunoglobulin, immunoglobulin mediated immune response, ...
Component immunoglobulin complex, circulating
Function antigen binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (3)
Theiler Stages: 28
Assay TypeResults
Immunohistochemistry 2
cDNA source data(1)
External Resources: Allen Institute  
Molecular
reagents
All nucleic(36) Genomic(27) cDNA(8) Other(1)
Other database
links
Ensembl Gene ModelENSMUSG00000095079 (Evidence)
International Mouse Knockout Project StatusIgha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000095079 Ensembl Gene Model | MGI Sequence Detail 1469 C57BL/6J ±  kb
transcript ENSMUST00000178282 Ensembl | MGI Sequence Detail 1034 Not Applicable 
polypeptide ENSMUSP00000137226 Ensembl | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(3)
Polymorphisms RFLP(4) : SNPs within 2kb(107 from dbSNP Build 137)
References (Earliest) J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
(Latest) J:187658 Khounlotham M, et al., Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis. Immunity. 2012 Sep 21;37(3):563-73
All references(74)
Other
accession IDs
MGD-MRK-11241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory