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Igha Gene Detail
Summary
  • Symbol
    Igha
  • Name
    immunoglobulin heavy constant alpha
  • Synonyms
    IgA, Igh-2
  • Feature Type
    gene segment
  • IDs
    MGI:96444
    NCBI Gene: 238447
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:113254830-113260236 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 62.09 cM
  • Mapping Data
    19 experiments
Homology
less
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051445 VEGA Gene Model | MGI Sequence Detail 5407 C57BL/6J ±  kb
    transcript OTTMUST00000130060 VEGA | MGI Sequence Detail 2540 Not Applicable  
    polypeptide OTTMUSP00000069776 VEGA | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      204 from dbSNP Build 142
    • RFLP
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 27
      cDNA 9
      Other 1
    Other
    Accession IDs
    less
    MGD-MRK-11241
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
    • Latest
      J:254160 Shalapour S, et al., Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 Nov 16;551(7680):340-345

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory