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Igha
Gene Detail
Symbol

Name
ID
Igha
immunoglobulin heavy constant alpha
MGI:96444
Synonyms
IgA, Igh-2
Feature Type
gene segment
Genetic Map
Chromosome 12
62.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr12:113258768-113260236 bp, - strand
From Ensembl annotation of GRCm38

  1469 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: immunoglobulin V region
Gene Tree: Igha
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(27) cDNA(9) Other(1)
Other database
links
Ensembl Gene ModelENSMUSG00000095079 (Evidence)
Entrez Gene238447 (Evidence)
International Mouse Knockout Project StatusIgha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000095079 Ensembl Gene Model | MGI Sequence Detail 1469 C57BL/6J ±  kb
transcript ENSMUST00000178282 Ensembl | MGI Sequence Detail 1034 Not Applicable 
polypeptide ENSMUSP00000137226 Ensembl | MGI Sequence Detail 344 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(4) : SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
References
(Earliest) J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
(Latest) J:209731 Chopra M, et al., Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. PLoS One. 2013;8(12):e81320
All references(80)
Other
accession IDs
MGD-MRK-11241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory