Igha Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Igha
immunoglobulin heavy constant alpha
MGI:96444

20 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Igha^tm1Grh/Igha^tm1Grh involves: 129 * C57BL/6	increased susceptibility to parasitic infection	J:74568, J:140515
Igha^tm1Grh/Igha^tm1Grh involves: 129S7/SvEvBrd * C57BL/6	abnormal dendritic cell physiology	J:125472
	abnormal immunoglobulin level	J:125472
	abnormal memory T cell physiology	J:125472
	abnormal T cell activation	J:53217
	decreased IgA level	J:53217, J:125472
	decreased IgE level	J:53217
	decreased IgG3 level	J:53217
	decreased interferon-gamma secretion	J:53217
	decreased T cell proliferation	J:125472
	normal immune system phenotype	J:53218
	increased IgG1 level	J:53217, J:125472
	increased IgG2a level	J:53217
	increased IgG2b level	J:53217
	increased IgG level	J:53217
	increased IgM level	J:53217, J:125472
	increased interferon-gamma secretion	J:125472
	increased interleukin-4 secretion	J:53217
	increased susceptibility to Orthomyxoviridae infection	J:125472
Igha^tm2Grh/Igha^tm2Grh involves: 129S7/SvEvBrd * C57BL/6	abnormal class switch recombination	J:72521

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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