Igha^tm2Grh
Targeted Allele Detail

Summary

• Symbol: Igha^tm2Grh
• Name: immunoglobulin heavy constant alpha; targeted mutation 2, Gregory Harriman
• MGI ID: MGI:2154386
• Gene: Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM
• Alliance: Igha^tm2Grh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72521
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An HPRT minigene replaced the I alpha exon that encodes untranslated mRNA upstream of the IgA switch region. Correct targeting was confirmed by Southern blot. (J:72521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igha Mutation: 16 strains or lines available

References

• Original: J:72521 Harriman GR, et al., IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination. J Clin Invest. 1996 Jan 15;97(2):477-85
• All: 1 reference(s)