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Igfbp2
Gene Detail
Symbol

Name
ID
Igfbp2
insulin-like growth factor binding protein 2
MGI:96437
Synonyms
Igfbp-2, IGFBP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:72824503-72852474 bp, + strand
From VEGA annotation of GRCm38

  27972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: IGFBP2
Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp2

Human
homologs
IGFBP2, insulin-like growth factor binding protein 2, 36kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3485
neXtProt AC: NX_P18065

Human Synonyms: IBP2, IGF-BP53

Human Chr (Location): 2q35; chr2:216633404-216664436 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced spleen, heart and kidney size and increased liver weight. Homozygotes for another allele exhibit a normal phenotype.
 
Interactions
Igfbp2 interacts with 60 markers (Mir27a, Mir27b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (38 records)
Data Summary: Results (244)    Tissues (178)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
Northern blot 19
Western blot 8
RT-PCR 20
cDNA source data(198)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA IGFBP2 ; Xenbase igfbp2 ; ZFIN igfbp2a, igfbp2b    NEW 
Molecular
reagents
All nucleic(208) Genomic(2) cDNA(202) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029573 (Evidence)
Ensembl Gene Model ENSMUSG00000039323 (Evidence)
Entrez Gene 16008 (Evidence)
UniGene 141936
DFCI TC1573007
DoTS DT.55107661, DT.94180954
NIA Mouse Gene Index U000430
Consensus CDS Project CCDS15036.1, CCDS78613.1
International Mouse Phenotyping Consortium Status Igfbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029573 VEGA Gene Model | MGI Sequence Detail 27972 C57BL/6J ±  kb
transcript OTTMUST00000073338 VEGA | MGI Sequence Detail 1307 Not Applicable 
polypeptide OTTMUSP00000037938 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR012210 Insulin-like growth factor binding protein 2
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008948 insulin-like growth factor-binding protein 2
References
(Earliest) J:11302 Agarwal N, et al., Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). Exp Eye Res. 1991 May;52(5):549-61
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(101)
Other
accession IDs
MGD-MRK-11232, MGD-MRK-11234, MGI:2138183

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory