Igfbp2
Gene Detail

Symbol Name ID

Igfbp2 insulin-like growth factor binding protein 2 MGI:96437

Synonyms

Igfbp-2, IGFBP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr1:72824503-72852474 bp, + strand From VEGA annotation of GRCm38   27972 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Igfbp2 ± 2 cM)

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp2

Human ortholog

IGFBP2 insulin-like growth factor binding protein 2, 36kDa NCBI Gene ID 3485
Human Synonyms: IBP2, IGF-BP53
Human Chr2:217498127-217529159 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(26) : Targeted(3) Gene trapped(23)
 

Homozygous mutation of this gene results in reduced spleen, heart and kidney size and increased liver weight. Homozygotes for another allele exhibit a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	positive regulation of activated T cell proliferation, regulation of cell growth, ...
Component	apical plasma membrane, cytoplasmic vesicle, ...
Function	growth factor binding, insulin-like growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (248)    Tissues (180)    Images (31)
Theiler Stages: 1, 2, 3, 4, 5, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	197
Northern blot	19
Western blot	8
RT-PCR	24

cDNA source data(190)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(199) Genomic(2) cDNA(194) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029573 (Evidence)
Ensembl Gene Model	ENSMUSG00000039323 (Evidence)
Entrez Gene	16008 (Evidence)
UniGene	141936
DFCI	TC1573007
DoTS	DT.55107661, DT.94180954
NIA Mouse Gene Index	U000430
Consensus CDS Project	CCDS15036.1
International Mouse Knockout Project Status	Igfbp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029573	VEGA Gene Model | MGI Sequence Detail	27972	C57BL/6J
transcript	OTTMUST00000073338	VEGA | MGI Sequence Detail	1307	Not Applicable
polypeptide	OTTMUSP00000037938	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR009168	Insulin-like growth factor binding protein
InterPro	IPR012210	Insulin-like growth factor binding protein 2
InterPro	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000008948	insulin-like growth factor-binding protein 2

References

(Earliest) J:11302 Agarwal N, et al., Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). Exp Eye Res. 1991 May;52(5):549-61
(Latest) J:189259 Shen X, et al., Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase beta and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol. 2012 Oct;32(20):4116-30
All references(93)

Other accession IDs

MGD-MRK-11232, MGD-MRK-11234, MGI:2138183