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Igfbp2 Gene Detail
Summary
  • Symbol
    Igfbp2
  • Name
    insulin-like growth factor binding protein 2
  • Synonyms
    Igfbp-2, IGFBP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96437
    NCBI Gene: 16008
  • Gene Overview
    MyGene.info: IGFBP2
Location & Maps
more
  • Sequence Map
    Chr1:72824503-72852474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      27972 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    IGFBP2, insulin like growth factor binding protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGFBP2, insulin like growth factor binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IBP2, IGF-BP53
  • Links
    NCBI Gene ID: 3485
    neXtProt AC: NX_P18065
    UniProt: P18065

  • Chr Location
    2q35; chr2:216632828-216664436 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced spleen, heart and kidney size and increased liver weight. Homozygotes for another allele exhibit a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    244
  • Tissues
    178
  • cDNA Data
    198
  • Literature Summary
    40
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029573 VEGA Gene Model | MGI Sequence Detail 27972 C57BL/6J ±  kb
transcript OTTMUST00000073338 VEGA | MGI Sequence Detail 1307 Not Applicable  
polypeptide OTTMUSP00000037938 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    146 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008948 insulin-like growth factor-binding protein 2
    (term hierarchy)
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR009168 Insulin-like growth factor binding protein
    IPR012210 Insulin-like growth factor binding protein 2
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
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  • All nucleic 208
    Genomic 2
    cDNA 202
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11232, MGD-MRK-11234, MGI:2138183
References
more
  • Summaries
    All 115
    Developmental Gene Expression 40
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:241556 Phillips LM, et al., Glioma progression is mediated by an addiction to aberrant IGFBP2 expression and can be blocked using anti-IGFBP2 strategies. J Pathol. 2016 Jul;239(3):355-64
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/15/2017
MGI 6.10 		The Jackson Laboratory