Igfbp2
Gene Detail

Symbol

Name
ID

Igfbp2
insulin-like growth factor binding protein 2
MGI:96437

Synonyms

Igfbp-2, IGFBP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 1
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr1:72824503-72852474 bp, + strand From VEGA annotation of GRCm38   27972 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp2

Human
homologs

Human Homolog		IGFBP2, insulin-like growth factor binding protein 2, 36kDa
NCBI Gene ID		3485
neXtProt AC		NX_P18065
Human Synonyms		IBP2, IGF-BP53
Human Chr (Location)		2q35; chr2:216633404-216664436 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(27) : Gene trapped(23) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene results in reduced spleen, heart and kidney size and increased liver weight. Homozygotes for another allele exhibit a normal phenotype.

 

Interactions

Igfbp2 interacts with 61 markers (Mir27a, Mir27b, Mir92-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	positive regulation of activated T cell proliferation, regulation of cell growth, ...
Component	apical plasma membrane, cytoplasmic vesicle, ...
Function	growth factor binding, insulin-like growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (37 records)

Data Summary: Results (244)    Tissues (178)    Images (32)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	197
Northern blot	19
Western blot	8
RT-PCR	20

cDNA source data(198)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(208) Genomic(2) cDNA(202) Primer pair(4)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000029573 (Evidence)
Ensembl Gene Model	ENSMUSG00000039323 (Evidence)
Entrez Gene	16008 (Evidence)
UniGene	141936
DFCI	TC1573007
DoTS	DT.55107661, DT.94180954
NIA Mouse Gene Index	U000430
Consensus CDS Project	CCDS15036.1
International Mouse Knockout Project Status	Igfbp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029573	VEGA Gene Model | MGI Sequence Detail	27972	C57BL/6J
transcript	OTTMUST00000073338	VEGA | MGI Sequence Detail	1307	Not Applicable
polypeptide	OTTMUSP00000037938	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(33) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(2) : SNPs within 2kb(147 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009168	Insulin-like growth factor binding protein
InterPro	IPR012210	Insulin-like growth factor binding protein 2
InterPro	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000008948	insulin-like growth factor-binding protein 2

References

(Earliest) J:11302 Agarwal N, et al., Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). Exp Eye Res. 1991 May;52(5):549-61
(Latest) J:215459 Hellbach N, et al., Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
All references(103)

Other
accession IDs

MGD-MRK-11232, MGD-MRK-11234, MGI:2138183