About   Help   FAQ
Igfbp2 Gene Detail
Summary
  • Symbol
    Igfbp2
  • Name
    insulin-like growth factor binding protein 2
  • Synonyms
    Igfbp-2, IGFBP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96437
    NCBI Gene: 16008
  • Gene Overview
    MyGene.info: IGFBP2
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72824503-72852474 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96437
 protein coding gene Chr1:72824480-72852474 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016136
 protein coding gene Chr1:73364158-73393013 (+)
A/J MGP_AJ_G0016119
 protein coding gene Chr1:70776780-70804606 (+)
AKR/J MGP_AKRJ_G0016076
 protein coding gene Chr1:72772126-72803052 (+)
BALB/cJ MGP_BALBcJ_G0016074
 protein coding gene Chr1:70859714-70887452 (+)
C3H/HeJ MGP_C3HHeJ_G0015905
 protein coding gene Chr1:73081943-73112447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016527
 protein coding gene Chr1:76203355-76234032 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014248
 protein coding gene Chr1:66435088-66462176 (+)
CAST/EiJ MGP_CASTEiJ_G0015489
 protein coding gene Chr1:72375672-72470489 (+)
CBA/J MGP_CBAJ_G0015878
 protein coding gene Chr1:78700510-78733924 (+)
DBA/2J MGP_DBA2J_G0015979
 protein coding gene Chr1:70122857-70151925 (+)
FVB/NJ MGP_FVBNJ_G0015982
 protein coding gene Chr1:69310107-69337305 (+)
LP/J MGP_LPJ_G0016051
 protein coding gene Chr1:74418977-74451890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016002
 protein coding gene Chr1:82138114-82170249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016574
 protein coding gene Chr1:72794986-72825714 (+)
PWK/PhJ MGP_PWKPhJ_G0015276
 protein coding gene Chr1:69576363-69665409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015054
 protein coding gene Chr1:72155031-72188868 (+)
WSB/EiJ MGP_WSBEiJ_G0015551
 protein coding gene Chr1:72624062-72653675 (+)



Homology
more
  • Human Ortholog
    IGFBP2, insulin like growth factor binding protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGFBP2, insulin like growth factor binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IBP2, IGF-BP53
  • Links
    NCBI Gene ID: 3485
    neXtProt AC: NX_P18065
    UniProt: P18065

  • Chr Location
    2q35; chr2:216632828-216664436 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced spleen, heart and kidney size and increased liver weight. Homozygotes for another allele exhibit a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    222
  • cDNA Data
    199
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039323 Ensembl Gene Model | MGI Sequence Detail 27972 C57BL/6J ±  kb
    transcript ENSMUST00000047328 Ensembl | MGI Sequence Detail 1307 Not Applicable  
    polypeptide ENSMUSP00000046610 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008948 insulin-like growth factor-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR009168 Insulin-like growth factor binding protein
      IPR012210 Insulin-like growth factor binding protein 2
      IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000716 Thyroglobulin type-1
      IPR036857 Thyroglobulin type-1 superfamily
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 2
      cDNA 204
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11232, MGD-MRK-11234, MGI:2138183
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 45
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:286597 Xi G, et al., Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice. Endocrinology. 2020 Apr 1;161(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    06/23/2020
    MGI 6.15     		The Jackson Laboratory