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Igfbp1
Gene Detail
 Symbol
Name
ID
Igfbp1
insulin-like growth factor binding protein 1
MGI:96436
Synonyms IGFBP-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
4.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:7197782-7202546 bp, + strand
From VEGA annotation of GRCm38

  4765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp1

Human
homologs
Human Homolog IGFBP1, insulin-like growth factor binding protein 1
NCBI Gene ID 3484
neXtProt AC  NX_P08833
Human Synonyms  AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12
Human Chr (Location)  7p13-p12; chr7:45888360-45893668 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene desplay a grossly normal phenotype but are more susceptible to liver injury.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of cell growth
Component extracellular region, extracellular space
Function growth factor binding, insulin-like growth factor binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (74)    Tissues (35)    Images (26)
Theiler Stages: 1, 2, 3, 4, 5, 11, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 25
Northern blot 19
RT-PCR 30
cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(100) Genomic(48) cDNA(45) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005136 (Evidence)
Ensembl Gene ModelENSMUSG00000020429 (Evidence)
Entrez Gene16006 (Evidence)
UniGene21300
DFCITC1581679
DoTSDT.494222
NIA Mouse Gene IndexU012307
Consensus CDS ProjectCCDS24427.1
International Mouse Knockout Project StatusIgfbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005136 VEGA Gene Model | MGI Sequence Detail 4765 C57BL/6J ±  kb
transcript OTTMUST00000011489 VEGA | MGI Sequence Detail 1525 Not Applicable 
polypeptide OTTMUSP00000005344 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR022322 Insulin-like growth factor-binding protein 1
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008947 insulin-like growth factor-binding protein 1
References (Earliest) J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
(Latest) J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
All references(89)
Other
accession IDs
MGD-MRK-11233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory