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Igfbp1 Gene Detail
Summary
  • Symbol
    Igfbp1
  • Name
    insulin-like growth factor binding protein 1
  • Synonyms
    IGFBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96436
    NCBI Gene: 16006
Location & Maps
more
Homology
more
  • Human Ortholog
    IGFBP1, insulin like growth factor binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGFBP1, insulin like growth factor binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12
  • Links
    NCBI Gene ID: 3484
    neXtProt AC: NX_P08833

  • Chr Location
    7p12.3; chr7:45888360-45893668 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene desplay a grossly normal phenotype but are more susceptible to liver injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005136 VEGA Gene Model | MGI Sequence Detail 4765 C57BL/6J ±  kb
transcript OTTMUST00000011489 VEGA | MGI Sequence Detail 1525 Not Applicable  
polypeptide OTTMUSP00000005344 VEGA | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    72 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008947 insulin-like growth factor-binding protein 1
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR009168 Insulin-like growth factor binding protein
    IPR022322 Insulin-like growth factor-binding protein 1
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
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  • All nucleic 100
    Genomic 48
    cDNA 45
    Primer pair 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11233
References
more
  • Summaries
    All 87
    Developmental Gene Expression 31
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
  • Latest
    J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory