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Igf2r Gene Detail
Summary
  • Symbol
    Igf2r
  • Name
    insulin-like growth factor 2 receptor
  • Synonyms
    CD222, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, mannose-6-phosphate receptor, cation independent, Mpr300
  • Feature Type
    protein coding gene
  • IDs
    MGI:96435
    NCBI Gene: 16004
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:12682406-12769664 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.64 cM, cytoband A-C
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    IGF2R, insulin like growth factor 2 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGF2R, insulin like growth factor 2 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD222, CI-M6PR, CIMPR, M6P/IGF2R, M6P-R, MPR1, MPR300, MPR 300, MPRI
  • Links
    NCBI Gene ID: 3482
    neXtProt AC: NX_P11717
    UniProt: P11717

  • Chr Location
    6q25.3; chr6:159969099-160111504 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IGF2R associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 8 alleles in 13 genetic backgrounds
    21 phenotypes from multigenic genotypes
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants inheriting maternally a targeted disruption of this gene exhibit elevated serum and tissue IGF-II levels, overgrowth, organomegaly, kinky tail, polydactyly, heart defects, edema, dyspnea, imperforate vagina, reduced fertility and perinatal death.Survival is influenced by genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034915 VEGA Gene Model | MGI Sequence Detail 87259 C57BL/6J ±  kb
    transcript OTTMUST00000088766 VEGA | MGI Sequence Detail 8887 Not Applicable  
    polypeptide OTTMUSP00000048420 VEGA | MGI Sequence Detail 2483 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      256 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 25
      cDNA 30
      Primer pair 15
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11231, MGI:2146909
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 67
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:9629 Laureys G, et al., Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics. 1988 Oct;3(3):224-9
    • Latest
      J:259885 Andergassen D, et al., Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 2017 Aug 14;6(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory