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Igf2r
Gene Detail
Symbol

Name
ID
Igf2r
insulin-like growth factor 2 receptor
MGI:96435
Synonyms
CD222, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, mannose-6-phosphate receptor, cation independent, Mpr300
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.64 cM, cytoband A-C
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:12682406-12769664 bp, - strand
From VEGA annotation of GRCm38

  87259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:676  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IGF2R
Protein SuperFamily: cation-independent mannose 6-phosphate receptor
Gene Tree: Igf2r

Human
homologs
IGF2R, insulin-like growth factor 2 receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3482
neXtProt AC: NX_P11717

Human Synonyms: CD222, CIMPR, M6P-R, MPR1, MPRI

Human Chr (Location): 6q26; chr6:159969099-160106551 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IGF2R

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutants inheriting maternally a targeted disruption of this gene exhibit elevated serum and tissue IGF-II levels, overgrowth, organomegaly, kinky tail, polydactyly, heart defects, edema, dyspnea, imperforate vagina, reduced fertility and perinatal death. Survival is influenced by genetic background.
 
Phenotype Images(3)
Interactions
Igf2r interacts with 310 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process G-protein coupled receptor signaling pathway, liver development, ...
Component cell surface, clathrin coat, ...
Function enzyme binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (338)    Tissues (115)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 109
Northern blot 12
Western blot 13
RT-PCR 140
RNase protection 52
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA IGF2R ; Xenbase igf2r ; ZFIN igf2r    NEW 
Molecular
reagents
All nucleic(75) Genomic(25) cDNA(30) Primer pair(15) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034915 (Evidence)
Ensembl Gene Model ENSMUSG00000023830 (Evidence)
Entrez Gene 16004 (Evidence)
DFCI TC1574144, TC1657031, TC1668926
DoTS DT.494630, DT.87047568
NIA Mouse Gene Index U037426
Consensus CDS Project CCDS37436.1
International Mouse Phenotyping Consortium Status Igf2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034915 VEGA Gene Model | MGI Sequence Detail 87259 C57BL/6J ±  kb
transcript OTTMUST00000088766 VEGA | MGI Sequence Detail 8887 Not Applicable 
polypeptide OTTMUSP00000048420 VEGA | MGI Sequence Detail 2483 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(3) : SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000479 Cation-independent mannose-6-phosphate receptor
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR013806 Kringle-like fold
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
Protein Ontology PR:000001333 cation-independent mannose-6-phosphate receptor
References
(Earliest) J:9629 Laureys G, et al., Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics. 1988 Oct;3(3):224-9
(Latest) J:218430 Kamimura S, et al., Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer. Biol Reprod. 2014 Nov;91(5):120
All references(167)
Other
accession IDs
MGD-MRK-11231, MGI:2146909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory