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Igf2r
Gene Detail
 Symbol
Name
ID
Igf2r
insulin-like growth factor 2 receptor
MGI:96435
Synonyms CD222, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, mannose-6-phosphate receptor, cation independent, Mpr300
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.64 cM, cytoband A-C
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:12682406-12769664 bp, - strand
From VEGA annotation of GRCm38

  87259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:676  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cation-independent mannose 6-phosphate receptor
Gene Tree: Igf2r

Human
homologs
Human Homolog IGF2R, insulin-like growth factor 2 receptor
NCBI Gene ID 3482
neXtProt AC  NX_P11717
Human Synonyms  CD222, CIMPR, M6P-R, MPR1, MPRI
Human Chr (Location)  6q26; chr6:159969099-160106551 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGF2R
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants inheriting maternally a targeted disruption of this gene exhibit elevated serum and tissue IGF-II levels, overgrowth, organomegaly, kinky tail, polydactyly, heart defects, edema, dyspnea, imperforate vagina, reduced fertility and perinatal death. Survival is influenced by genetic background.
 
Interactions
Igf2r interacts with 311 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process G-protein coupled receptor signaling pathway, liver development, ...
Component cell surface, clathrin coat, ...
Function enzyme binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (338)    Tissues (115)    Images (38)
Theiler Stages: 2, 3, 5, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 109
Northern blot 12
Western blot 13
RT-PCR 140
RNase protection 52
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) Genomic(25) cDNA(29) Primer pair(15) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034915 (Evidence)
Ensembl Gene ModelENSMUSG00000023830 (Evidence)
Entrez Gene16004 (Evidence)
DFCITC1574144, TC1657031, TC1668926
DoTSDT.494630, DT.87047568
NIA Mouse Gene IndexU037426
Consensus CDS ProjectCCDS37436.1
International Mouse Knockout Project StatusIgf2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034915 VEGA Gene Model | MGI Sequence Detail 87259 C57BL/6J ±  kb
transcript OTTMUST00000088766 VEGA | MGI Sequence Detail 8887 Not Applicable 
polypeptide OTTMUSP00000048420 VEGA | MGI Sequence Detail 2483 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(2) UniProt(11)
Polymorphisms RFLP(3) : SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000479 Cation-independent mannose-6-phosphate receptor
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR013806 Kringle-like fold
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
Protein Ontology PR:000001333 cation-independent mannose-6-phosphate receptor
References (Earliest) J:9629 Laureys G, et al., Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics. 1988 Oct;3(3):224-9
(Latest) J:212055 Farah BL, et al., Adjunctive beta2-agonist treatment reduces glycogen independently of receptor-mediated acid alpha-glucosidase uptake in the limb muscles of mice with Pompe disease. FASEB J. 2014 May;28(5):2272-80
All references(163)
Other
accession IDs
MGD-MRK-11231, MGI:2146909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory