Igf2r
Gene Detail

Symbol Name ID

Igf2r insulin-like growth factor 2 receptor MGI:96435

Synonyms

CD222, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, mannose-6-phosphate receptor, cation independent, Mpr300

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.64 cM, cytoband A-C
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr17:12682406-12769664 bp, - strand From VEGA annotation of GRCm38   87259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:676  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cation-independent mannose 6-phosphate receptor
Gene Tree: Igf2r

Human homologs

Human Homolog		IGF2R, insulin-like growth factor 2 receptor
NCBI Gene ID		3482
neXtProt AC		NX_P11717
Human Synonyms		CD222, CIMPR, M6P-R, MPR1, MPRI
Human Chr (Location)		6q26; chr6:160390131-160527583 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(7) Gene trapped(5)
 

Mutants inheriting maternally a targeted disruption of this gene exhibit elevated serum and tissue IGF-II levels, overgrowth, organomegaly, kinky tail, polydactyly, heart defects, edema, dyspnea, imperforate vagina, reduced fertility and perinatal death. Survival is influenced by genetic background.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	G-protein coupled receptor signaling pathway, liver development, ...
Component	cell surface, clathrin coat, ...
Function	enzyme binding, glycoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (57 records)
Data Summary: Results (344)    Tissues (116)    Images (37)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	109
Northern blot	12
Western blot	13
RT-PCR	146
RNase protection	52

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(74) Genomic(25) cDNA(29) Primer pair(15) Other(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000034915 (Evidence)
Ensembl Gene Model	ENSMUSG00000023830 (Evidence)
Entrez Gene	16004 (Evidence)
DFCI	TC1574144, TC1657031, TC1668926
DoTS	DT.494630, DT.87047568
NIA Mouse Gene Index	U037426
Consensus CDS Project	CCDS37436.1
International Mouse Knockout Project Status	Igf2r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034915	VEGA Gene Model | MGI Sequence Detail	87259	C57BL/6J
transcript	OTTMUST00000088766	VEGA | MGI Sequence Detail	8887	Not Applicable
polypeptide	OTTMUSP00000048420	VEGA | MGI Sequence Detail	2483	Not Applicable

All sequences(117) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(3) : SNPs(238 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000479	Cation-independent mannose-6-phosphate receptor
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009011	Mannose-6-phosphate receptor binding domain
Protein Ontology	PR:000001333	cation-independent mannose-6-phosphate receptor

References

(Earliest) J:9629 Laureys G, et al., Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics. 1988 Oct;3(3):224-9
(Latest) J:192195 Himes KP, et al., Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
All references(158)

Other accession IDs

MGD-MRK-11231, MGI:2146909