About   Help   FAQ
Ido1
Gene Detail
Symbol

Name
ID
Ido1
indoleamine 2,3-dioxygenase 1
MGI:96416
Synonyms
Ido, Indo
Feature Type
protein coding gene
Genetic Map
Chromosome 8
12.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:24584136-24597009 bp, - strand
From VEGA annotation of GRCm38

  12874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: indoleamine 2,3-dioxygenase
Gene Tree: Ido1

Human
homologs
Human Homolog IDO1, indoleamine 2,3-dioxygenase 1
NCBI Gene ID 3620
neXtProt AC  NX_P14902
Human Synonyms  IDO, IDO-1, INDO
Human Chr (Location)  8p12-p11; chr8:39913809-39928790 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity.
 
Interactions
Ido1 interacts with 61 markers (Mir29a, Mir96, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cytokine production involved in inflammatory response, defense response, ...
Component cytoplasm, cytosol, ...
Function amino acid binding, dioxygenase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (102)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000020648 (Evidence)
Ensembl Gene ModelENSMUSG00000031551 (Evidence)
Entrez Gene15930 (Evidence)
UniGene392
DFCITC1589037, TC1619352
DoTSDT.101714753, DT.40185387
NIA Mouse Gene IndexU029652
EC1.13.11.52
Consensus CDS ProjectCCDS40299.1
International Mouse Knockout Project StatusIdo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020648 VEGA Gene Model | MGI Sequence Detail 12874 C57BL/6J ±  kb
transcript OTTMUST00000048915 VEGA | MGI Sequence Detail 1560 Not Applicable 
polypeptide OTTMUSP00000022551 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000898 Indoleamine 2,3-dioxygenase
Protein Ontology PR:000009030 indoleamine 2,3-dioxygenase 1
References
(Earliest) J:72138 Takikawa O, et al., Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem. 1986 Mar 15;261(8):3648-53
(Latest) J:215178 Masoumy M, et al., The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury. PLoS One. 2014;9(4):e95720
All references(100)
Other
accession IDs
MGD-MRK-11186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory