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Ido1
Gene Detail
Symbol

Name
ID
Ido1
indoleamine 2,3-dioxygenase 1
MGI:96416
Synonyms
Ido, Indo
Feature Type
protein coding gene
Genetic Map
Chromosome 8
12.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:24584136-24597009 bp, - strand
From VEGA annotation of GRCm38

  12874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IDO1
Protein SuperFamily: indoleamine 2,3-dioxygenase
Gene Tree: Ido1

Human
homologs
IDO1, indoleamine 2,3-dioxygenase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3620
neXtProt AC: NX_P14902

Human Synonyms: IDO, IDO-1, INDO

Human Chr (Location): 8p12-p11; chr8:39913809-39928790 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity.
 
Interactions
Ido1 interacts with 61 markers (Mir29a, Mir96, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cytokine production involved in inflammatory response, defense response, ...
Component cytoplasm, cytosol, ...
Function amino acid binding, dioxygenase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (102)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ido1    NEW 
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020648 (Evidence)
Ensembl Gene Model ENSMUSG00000031551 (Evidence)
Entrez Gene 15930 (Evidence)
UniGene 392
DFCI TC1589037, TC1619352
DoTS DT.101714753, DT.40185387
NIA Mouse Gene Index U029652
EC 1.13.11.52
Consensus CDS Project CCDS40299.1
International Mouse Phenotyping Consortium Status Ido1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020648 VEGA Gene Model | MGI Sequence Detail 12874 C57BL/6J ±  kb
transcript OTTMUST00000048915 VEGA | MGI Sequence Detail 1560 Not Applicable 
polypeptide OTTMUSP00000022551 VEGA | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000898 Indoleamine 2,3-dioxygenase
Protein Ontology PR:000009030 indoleamine 2,3-dioxygenase 1
References
(Earliest) J:72138 Takikawa O, et al., Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem. 1986 Mar 15;261(8):3648-53
(Latest) J:222060 Vidal C, et al., The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. Stem Cells. 2015 Jan;33(1):111-21
All references(103)
Other
accession IDs
MGD-MRK-11186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory