Idh2
Gene Detail

Symbol Name ID

Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial MGI:96414

Synonyms

Idh-2, IDPm

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:80094846-80115392 bp, - strand From VEGA annotation of GRCm38   20547 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: isocitrate dehydrogenase (NADP)
Gene Tree: Idh2

Human homologs

Human Homolog		IDH2, isocitrate dehydrogenase 2 (NADP+), mitochondrial
NCBI Gene ID		3418
neXtProt AC		NX_P48735
Human Synonyms		D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
Human Chr (Location)		15q26.1; chr15:90627210-90645708 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IDH2

Alleles and phenotypes

All alleles(86) : Targeted(2) Gene trapped(84)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	glyoxylate cycle, isocitrate metabolic process, ...
Component	mitochondrial inner membrane, mitochondrion
Function	isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (216)    Tissues (143)    Images (24)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	124
RT-PCR	92

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024961 (Evidence)
Ensembl Gene Model	ENSMUSG00000030541 (Evidence)
Entrez Gene	269951 (Evidence)
EC	1.1.1.42
Consensus CDS Project	CCDS39994.1
International Mouse Knockout Project Status	Idh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024961	VEGA Gene Model | MGI Sequence Detail	20547	C57BL/6J
transcript	OTTMUST00000061456	VEGA | MGI Sequence Detail	1745	Not Applicable
polypeptide	OTTMUSP00000030144	VEGA | MGI Sequence Detail	452	Not Applicable

All sequences(46) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004790	Isocitrate dehydrogenase NADP-dependent
InterPro	IPR019818	Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro	IPR024084	Isopropylmalate dehydrogenase-like domain
Protein Ontology	PR:000008888	isocitrate dehydrogenase [NADP], mitochondrial

References

(Earliest) J:5950 Krog HH, et al., Genetic characterization of important mouse strains used in cancer research. Hereditas. 1977;87(2):201-4
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(43)

Other accession IDs

MGD-MRK-11181, MGD-MRK-11184