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Idh2
Gene Detail
 Symbol
Name
ID
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
MGI:96414
Synonyms Idh-2, IDPm
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:80094846-80115392 bp, - strand
From VEGA annotation of GRCm38

  20547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: isocitrate dehydrogenase (NADP)
Gene Tree: Idh2

Human
homologs
Human Homolog IDH2, isocitrate dehydrogenase 2 (NADP+), mitochondrial
NCBI Gene ID 3418
neXtProt AC  NX_P48735
Human Synonyms  D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
Human Chr (Location)  15q26.1; chr15:90083978-90102476 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IDH2
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Gene trapped(84) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit suppression of tumorigenesis from B16F10 melanoma cells.
 
Interactions
Idh2 interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glyoxylate cycle, isocitrate metabolic process, ...
Component extracellular vesicular exosome, mitochondrial inner membrane, ...
Function isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (216)    Tissues (143)    Images (24)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 124
RT-PCR 92
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024961 (Evidence)
Ensembl Gene ModelENSMUSG00000030541 (Evidence)
Entrez Gene269951 (Evidence)
EC1.1.1.42
Consensus CDS ProjectCCDS39994.1
International Mouse Knockout Project StatusIdh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024961 VEGA Gene Model | MGI Sequence Detail 20547 C57BL/6J ±  kb
transcript OTTMUST00000061456 VEGA | MGI Sequence Detail 1745 Not Applicable 
polypeptide OTTMUSP00000030144 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004790 Isocitrate dehydrogenase NADP-dependent
InterPro IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro IPR024084 Isopropylmalate dehydrogenase-like domain
Protein Ontology PR:000008888 isocitrate dehydrogenase [NADP], mitochondrial
References (Earliest) J:5950 Krog HH, et al., Genetic characterization of important mouse strains used in cancer research. Hereditas. 1977;87(2):201-4
(Latest) J:210036 Kim S, et al., Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice. Biochim Biophys Acta. 2014 Feb;1842(2):135-43
All references(46)
Other
accession IDs
MGD-MRK-11181, MGD-MRK-11184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory