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Id3
Gene Detail
Symbol

Name
ID
Id3
inhibitor of DNA binding 3
MGI:96398
Synonyms
bHLHb25, HLH462, Idb3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
68.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:136143497-136145755 bp, + strand
From VEGA annotation of GRCm38

  2259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1633  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ID3
Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id3

Human
homologs
ID3, inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3399
neXtProt AC: NX_Q02535

Human Synonyms: bHLHb25, HEIR-1

Human Chr (Location): 1p36.13-p36.12; chr1:23557930-23559794 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(4) Targeted(8)
Genomic Mutations involving Id3 (1)
 
Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain.
 
Human Diseases Modeled in Mice Using Id3 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Id3 interacts with 140 markers (Mir15a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process epithelial cell differentiation, heart development, ...
Component cytoplasm, microtubule cytoskeleton, ...
Function protein binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (69 records)
Data Summary: Results (324)    Tissues (227)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 190
Northern blot 19
Western blot 3
RT-PCR 105
cDNA source data(190)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase id3 ; ZFIN id3    NEW 
Molecular
reagents
All nucleic(205) Genomic(1) cDNA(193) Primer pair(9) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009864 (Evidence)
Ensembl Gene Model ENSMUSG00000007872 (Evidence)
Entrez Gene 15903 (Evidence)
UniGene 110
DFCI TC1574082, TC1582478
DoTS DT.101304621, DT.101322980, DT.110841457, DT.110841477, DT.110842041, DT.55123207, DT.99858479
NIA Mouse Gene Index U004959
Consensus CDS Project CCDS18800.1
International Mouse Phenotyping Consortium Status Id3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009864 VEGA Gene Model | MGI Sequence Detail 2259 C57BL/6J ±  kb
transcript OTTMUST00000022874 VEGA | MGI Sequence Detail 1278 Not Applicable 
polypeptide OTTMUSP00000010436 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000041 DNA-binding protein inhibitor ID-3
References
(Earliest) J:13202 Christy BA, et al., An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1815-9
(Latest) J:219556 Miyazaki M, et al., The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015 Feb 15;29(4):409-25
All references(184)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-11155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory