Id3
Gene Detail

Symbol Name ID

Id3 inhibitor of DNA binding 3 MGI:96398

Synonyms

bHLHb25, HLH462, Idb3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

68.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr4:136143497-136145755 bp, + strand From VEGA annotation of GRCm38   2259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1633  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id3

Human homologs

Human Homolog		ID3, inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NCBI Gene ID		3399
neXtProt AC		NX_Q02535
Human Synonyms		bHLHb25, HEIR-1
Human Chr (Location)		1p36.13-p36.12; chr1:23884421-23886285 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(4)
 

Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain.

 
Human Diseases Modeled Using Mouse Id3 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	epithelial cell differentiation, heart development, ...
Component	cytoplasm, nucleus
Function	protein binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (60 records)
Data Summary: Results (288)    Tissues (208)    Images (16)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	174
Northern blot	19
Western blot	3
RT-PCR	85

cDNA source data(189)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(203) Genomic(1) cDNA(192) Primer pair(8) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009864 (Evidence)
Ensembl Gene Model	ENSMUSG00000007872 (Evidence)
Entrez Gene	15903 (Evidence)
UniGene	110
DFCI	TC1574082, TC1582478
DoTS	DT.101304621, DT.101322980, DT.110841457, DT.110841477, DT.110842041, DT.55123207, DT.99858479
NIA Mouse Gene Index	U004959
Consensus CDS Project	CCDS18800.1
International Mouse Knockout Project Status	Id3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009864	VEGA Gene Model | MGI Sequence Detail	2259	C57BL/6J
transcript	OTTMUST00000022874	VEGA | MGI Sequence Detail	1278	Not Applicable
polypeptide	OTTMUSP00000010436	VEGA | MGI Sequence Detail	119	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026052	DNA-binding protein inhibitor
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000000041	DNA-binding protein inhibitor ID-3

References

(Earliest) J:13202 Christy BA, et al., An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1815-9
(Latest) J:194297 Niola F, et al., Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. J Clin Invest. 2013 Jan 2;123(1):405-17
All references(162)

Other accession IDs

MGD-MRK-11155