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Id3
Gene Detail
Symbol

Name
ID
Id3
inhibitor of DNA binding 3
MGI:96398
Synonyms
bHLHb25, HLH462, Idb3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
68.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:136143497-136145755 bp, + strand
From VEGA annotation of GRCm38

  2259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1633  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id3

Human
homologs
Human Homolog ID3, inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
NCBI Gene ID 3399
neXtProt AC  NX_Q02535
Human Synonyms  bHLHb25, HEIR-1
Human Chr (Location)  1p36.13-p36.12; chr1:23557930-23559794 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
 
Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain.
 
Human Diseases Modeled Using Mouse Id3 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Id3 interacts with 140 markers (Mir15a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process epithelial cell differentiation, heart development, ...
Component cytoplasm, microtubule cytoskeleton, ...
Function protein binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (324)    Tissues (227)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 190
Northern blot 19
Western blot 3
RT-PCR 105
cDNA source data(190)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(205) Genomic(1) cDNA(193) Primer pair(9) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009864 (Evidence)
Ensembl Gene ModelENSMUSG00000007872 (Evidence)
Entrez Gene15903 (Evidence)
UniGene110
DFCITC1574082, TC1582478
DoTSDT.101304621, DT.101322980, DT.110841457, DT.110841477, DT.110842041, DT.55123207, DT.99858479
NIA Mouse Gene IndexU004959
Consensus CDS ProjectCCDS18800.1
International Mouse Knockout Project StatusId3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009864 VEGA Gene Model | MGI Sequence Detail 2259 C57BL/6J ±  kb
transcript OTTMUST00000022874 VEGA | MGI Sequence Detail 1278 Not Applicable 
polypeptide OTTMUSP00000010436 VEGA | MGI Sequence Detail 119 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000041 DNA-binding protein inhibitor ID-3
References
(Earliest) J:13202 Christy BA, et al., An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1815-9
(Latest) J:209824 D'Cruz LM, et al., E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014 Mar 1;192(5):2227-36
All references(179)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-11155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory