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Id2
Gene Detail
 Symbol
Name
ID
Id2
inhibitor of DNA binding 2
MGI:96397
Synonyms bHLHb26, C78922, Idb2, inhibitor of differentiation 2
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.57 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:25093801-25096092 bp, - strand
From Ensembl annotation of GRCm38

  2292 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1632  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA-binding protein inhibitor, ID type
Gene Tree: Id2

Human
homologs
Human Homolog ID2, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
NCBI Gene ID 3398
neXtProt AC  NX_Q02363
Human Synonyms  bHLHb26, GIG8, ID2A, ID2H
Human Chr (Location)  2p25; chr2:8681983-8684453 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display postnatal lethality with immune system defects. Homozygotes may also have defects in the digestive tract, kidneys, adipose tissue and in mammary gland development.
 
Interactions
Id2 interacts with 220 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process adipose tissue development, bundle of His development, ...
Component centrosome, chromatin, ...
Function ion channel binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (133 records)
Data Summary: Results (372)    Tissues (238)    Images (56)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 270
Northern blot 8
Western blot 3
RT-PCR 80
cDNA source data(206)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(223) Genomic(3) cDNA(209) Primer pair(8) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000020644 (Evidence)
Entrez Gene15902 (Evidence)
UniGene34871
DFCITC1573501, TC1588610, TC1646201
DoTSDT.537325, DT.55109029, DT.94246421, DT.97381678
NIA Mouse Gene IndexU033848
Consensus CDS ProjectCCDS25846.1
International Mouse Knockout Project StatusId2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020644 Ensembl Gene Model | MGI Sequence Detail 2292 C57BL/6J ±  kb
transcript ENSMUST00000020974 Ensembl | MGI Sequence Detail 1270 Not Applicable 
polypeptide ENSMUSP00000020974 Ensembl | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026052 DNA-binding protein inhibitor
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000000040 DNA-binding protein inhibitor ID-2
References (Earliest) J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
(Latest) J:209953 Kurashima Y, et al., The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17;40(4):530-41
All references(272)
Other
accession IDs
MGD-MRK-11154, MGI:2144775, MGI:2145094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory