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Id2 Gene Detail
Summary
  • Symbol
    Id2
  • Name
    inhibitor of DNA binding 2
  • Synonyms
    bHLHb26, C78922, Idb2, inhibitor of differentiation 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96397
    NCBI Gene: 15902
Location & Maps
more
  • Sequence Map
    Chr12:25093801-25096092 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2292 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ID2, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ID2, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
    Orthology source: HomoloGene
  • Synonyms
    bHLHb26, GIG8, ID2A, ID2H
  • Links
    NCBI Gene ID: 3398
    neXtProt AC: NX_Q02363

  • Chr Location
    2p25; chr2:8681983-8684453 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 6 alleles in 9 genetic backgrounds
    27 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    1
  • Targeted
    14
  • Incidental Mutations
Mice homozygous for disruptions in this gene display postnatal lethality with immune system defects. Homozygotes may also have defects in the digestive tract, kidneys, adipose tissue and in mammary gland development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020644 Ensembl Gene Model | MGI Sequence Detail 2292 C57BL/6J ±  kb
transcript ENSMUST00000020974 Ensembl | MGI Sequence Detail 1270 Not Applicable  
polypeptide ENSMUSP00000020974 Ensembl | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000040 DNA-binding protein inhibitor ID-2
  • InterPro Domains
    IPR026052 DNA-binding protein inhibitor
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 225
    Genomic 3
    cDNA 209
    Primer pair 9
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11154, MGI:2144775, MGI:2145094
References
more
  • Summaries
    All 288
    Developmental Gene Expression 142
    Gene Ontology 37
    Phenotypes 95
  • Earliest
    J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
  • Latest
    J:227252 Hayakawa Y, et al., Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015 Dec 14;28(6):800-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory