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Hspg2
Gene Detail
 Symbol
Name
ID
Hspg2
perlecan (heparan sulfate proteoglycan 2)
MGI:96257
Synonyms Pcn, per, Plc
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:137468769-137570630 bp, + strand
From VEGA annotation of GRCm38

  101862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68473  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hspg2

Human
homologs
Human Homolog HSPG2, heparan sulfate proteoglycan 2
NCBI Gene ID 3339
neXtProt AC  NX_P98160
Human Synonyms  HSPG, PLC, PRCAN, SJA, SJS, SJS1
Human Chr (Location)  1p36.1-p34; chr1:21822244-21937257 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human HSPG2
Mutations,
alleles, and
phenotypes
All mutations/alleles(229) : Gene trapped(221) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted null mutants die either at embryonic day 10.5 with cardiac outflow defects and/or brain exencephaly or at birth with skeletal dysplasia including micromelia and craniofacial defects. An exon 3 deletion mutant shows only a lens defect.
 
Human Diseases Modeled Using Mouse Hspg2 (4)    Alleles Annotated to Human Diseases(5)    Phenotype Images(6)
Interactions
Hspg2 interacts with 220 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process angiogenesis, brain development, ...
Component basal lamina, basement membrane, ...
Function metal ion binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (184)    Tissues (137)    Images (49)
Theiler Stages: 3, 4, 5, 11, 14, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 103
RNA in situ 24
RT-PCR 57
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(121) cDNA(116) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009935 (Evidence)
Ensembl Gene ModelENSMUSG00000028763 (Evidence)
Entrez Gene15530 (Evidence)
UniGene273662
DFCITC1577147, TC1649731, TC1676755
DoTSDT.101149714, DT.110794729, DT.497264, DT.55187568
NIA Mouse Gene IndexU004983
PDB1GL4
Consensus CDS ProjectCCDS51333.1
International Mouse Knockout Project StatusHspg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009935 VEGA Gene Model | MGI Sequence Detail 101862 C57BL/6J ±  kb
transcript OTTMUST00000023078 VEGA | MGI Sequence Detail 14187 Not Applicable 
polypeptide OTTMUSP00000010529 VEGA | MGI Sequence Detail 4375 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(1413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR000082 SEA domain
Protein Ontology PR:000008826 basement membrane-specific heparan sulfate proteoglycan core protein
References (Earliest) J:23350 Ledbetter SR, et al., Identification of the precursor protein to basement membrane heparan sulfate proteoglycans. J Biol Chem. 1985 Jul 5;260(13):8106-113
(Latest) J:203017 Ida-Yonemochi H, et al., Reciprocal expressions between alpha-dystroglycan and integrin beta1, perlecan receptors, in the murine enamel organ development. Gene Expr Patterns. 2013 Dec;13(8):293-302
All references(161)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-10976, MGD-MRK-13349, MGI:2140391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory