Hspg2
Gene Detail

Symbol Name ID

Hspg2 perlecan (heparan sulfate proteoglycan 2) MGI:96257

Synonyms

Pcn, per, Plc

Feature Type

protein coding gene

Genetic Map

Chromosome 4

69.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:137468769-137570630 bp, + strand From VEGA annotation of GRCm38   101862 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68473  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hspg2

Human homologs

Human Homolog		HSPG2, heparan sulfate proteoglycan 2
NCBI Gene ID		3339
neXtProt AC		NX_P98160
Human Synonyms		HSPG, PLC, PRCAN, SJA, SJS, SJS1
Human Chr (Location)		1p36.1-p34; chr1:22148737-22263750 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HSPG2

Alleles and phenotypes

All alleles(229) : Targeted(8) Gene trapped(221)
 

Homozygous targeted null mutants die either at embryonic day 10.5 with cardiac outflow defects and/or brain exencephaly or at birth with skeletal dysplasia including micromelia and craniofacial defects. An exon 3 deletion mutant shows only a lens defect.

 
Human Diseases Modeled Using Mouse Hspg2 (4)    Alleles Annotated to Human Diseases(5)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	angiogenesis, brain development, ...
Component	basal lamina, basement membrane, ...
Function	metal ion binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (85 records)
Data Summary: Results (143)    Tissues (109)    Images (27)
Theiler Stages: 11, 14, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	78
RNA in situ	10
RT-PCR	55

cDNA source data(108)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(114) cDNA(110) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009935 (Evidence)
Ensembl Gene Model	ENSMUSG00000028763 (Evidence)
Entrez Gene	15530 (Evidence)
UniGene	273662
DFCI	TC1577147, TC1649731, TC1676755
DoTS	DT.101149714, DT.110794729, DT.497264, DT.55187568
NIA Mouse Gene Index	U004983
PDB	1GL4
Consensus CDS Project	CCDS51333.1
International Mouse Knockout Project Status	Hspg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009935	VEGA Gene Model | MGI Sequence Detail	101862	C57BL/6J
transcript	OTTMUST00000023078	VEGA | MGI Sequence Detail	14187	Not Applicable
polypeptide	OTTMUSP00000010529	VEGA | MGI Sequence Detail	4375	Not Applicable

All sequences(44) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(599 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR001791	Laminin G domain
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR000082	SEA
Protein Ontology	PR:000008826	basement membrane-specific heparan sulfate proteoglycan core protein

References

(Earliest) J:23350 Ledbetter SR, et al., Identification of the precursor protein to basement membrane heparan sulfate proteoglycans. J Biol Chem. 1985 Jul 5;260(13):8106-113
(Latest) J:194150 Wright KM, et al., Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012 Dec 6;76(5):931-44
All references(152)

Other accession IDs

MGD-MRK-10976, MGD-MRK-13349, MGI:2140391