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Hspg2
Gene Detail
Symbol

Name
ID
Hspg2
perlecan (heparan sulfate proteoglycan 2)
MGI:96257
Synonyms
Pcn, per, Plc
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:137468769-137570630 bp, + strand
From VEGA annotation of GRCm38

  101862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68473  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HSPG2
Gene Tree: Hspg2

Human
homologs
HSPG2, heparan sulfate proteoglycan 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3339
neXtProt AC: NX_P98160

Human Synonyms: HSPG, PLC, PRCAN, SJA, SJS, SJS1

Human Chr (Location): 1p36.1-p34; chr1:21822232-21937297 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HSPG2

Mutations,
alleles, and
phenotypes
All mutations/alleles(230) : Gene trapped(221) Targeted(9)
Genomic Mutations involving Hspg2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted null mutants die either at embryonic day 10.5 with cardiac outflow defects and/or brain exencephaly or at birth with skeletal dysplasia including micromelia and craniofacial defects. An exon 3 deletion mutant shows only a lens defect.
 
Human Diseases Modeled in Mice Using Hspg2 (4)    Mutations Annotated to Human Diseases (5)    Phenotype Images(6)
Interactions
Hspg2 interacts with 219 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process angiogenesis, brain development, ...
Component basal lamina, basement membrane, ...
Function metal ion binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (94 records)
Data Summary: Results (183)    Tissues (135)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 102
RNA in situ 24
RT-PCR 57
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hspg2 ; ZFIN hspg2    NEW 
Molecular
reagents
All nucleic(121) cDNA(116) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009935 (Evidence)
Ensembl Gene Model ENSMUSG00000028763 (Evidence)
Entrez Gene 15530 (Evidence)
UniGene 273662
DFCI TC1577147, TC1649731, TC1676755
DoTS DT.101149714, DT.110794729, DT.497264, DT.55187568
NIA Mouse Gene Index U004983
PDB 1GL4
Consensus CDS Project CCDS51333.1
International Mouse Phenotyping Consortium Status Hspg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009935 VEGA Gene Model | MGI Sequence Detail 101862 C57BL/6J ±  kb
transcript OTTMUST00000023078 VEGA | MGI Sequence Detail 14187 Not Applicable 
polypeptide OTTMUSP00000010529 VEGA | MGI Sequence Detail 4375 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(1413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR000082 SEA domain
Protein Ontology PR:000008826 basement membrane-specific heparan sulfate proteoglycan core protein
References
(Earliest) J:23350 Ledbetter SR, et al., Identification of the precursor protein to basement membrane heparan sulfate proteoglycans. J Biol Chem. 1985 Jul 5;260(13):8106-113
(Latest) J:218940 Barnette DN, et al., RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. PLoS One. 2014;9(7):e101425
All references(165)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-10976, MGD-MRK-13349, MGI:2140391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory