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Hspg2 Gene Detail
Summary
  • Symbol
    Hspg2
  • Name
    perlecan (heparan sulfate proteoglycan 2)
  • Synonyms
    Pcn, per, perlecan, Plc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96257
    NCBI Gene: 15530
  • Gene Overview
    MyGene.info: HSPG2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137468769-137570630 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.93 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96257
protein coding gene Chr4:137468764-137570630 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028983
protein coding gene Chr4:140102454-140216974 (+)
A/J MGP_AJ_G0028942
protein coding gene Chr4:134146192-134253516 (+)
AKR/J MGP_AKRJ_G0028894
protein coding gene Chr4:138003541-138103964 (+)
BALB/cJ MGP_BALBcJ_G0028966
protein coding gene Chr4:134829409-134930799 (+)
C3H/HeJ MGP_C3HHeJ_G0028680
protein coding gene Chr4:138333045-138442425 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029407
protein coding gene Chr4:145106535-145219771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026678
protein coding gene Chr4:127157617-127259958 (+)
CAST/EiJ MGP_CASTEiJ_G0028112
protein coding gene Chr4:136469326-136580256 (+)
CBA/J MGP_CBAJ_G0028645
protein coding gene Chr4:149181134-149302725 (+)
DBA/2J MGP_DBA2J_G0028794
protein coding gene Chr4:134539752-134642973 (+)
FVB/NJ MGP_FVBNJ_G0028761
protein coding gene Chr4:133534791-133641219 (+)
LP/J MGP_LPJ_G0028893
protein coding gene Chr4:140200236-140309029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028787
protein coding gene Chr4:153232061-153342288 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029445
protein coding gene Chr4:138477388-138583225 (+)
PWK/PhJ MGP_PWKPhJ_G0027832
protein coding gene Chr4:131361620-131465442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027658
protein coding gene Chr4:134255414-134362985 (+)
WSB/EiJ MGP_WSBEiJ_G0028190
protein coding gene Chr4:138675199-138785565 (+)



Homology
more
  • Human Ortholog
    HSPG2, heparan sulfate proteoglycan 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HSPG2, heparan sulfate proteoglycan 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPG, PLC, PRCAN, SJA, SJS, SJS1
  • Links
    NCBI Gene ID: 3339
    neXtProt AC: NX_P98160
    UniProt: P98160

  • Chr Location
    1p36.12; chr1:21822232-21937297 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68473
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HSPG2
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with Hspg2 mouse models; 2 with human HSPG2 associations

Human Disease Mouse Models
      
IDs
View 6 models
IDs
View 2 models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    130 phenotypes from 7 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    6 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die either at embryonic day 10.5 with cardiac outflow defects and/or brain exencephaly or at birth with skeletal dysplasia including micromelia and craniofacial defects. An exon 3 deletion mutant shows only a lens defect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028763 Ensembl Gene Model | MGI Sequence Detail 101862 C57BL/6J ±  kb
    transcript ENSMUST00000171332 Ensembl | MGI Sequence Detail 14176 Not Applicable  
    polypeptide ENSMUSP00000131316 Ensembl | MGI Sequence Detail 4383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 118
      Primer pair 6
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10976, MGD-MRK-13349, MGI:2140391
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 103
      Diseases 8
      Gene Ontology 23
      Phenotypes 41
    • Earliest
      J:23350 Ledbetter SR, et al., Identification of the precursor protein to basement membrane heparan sulfate proteoglycans. J Biol Chem. 1985 Jul 5;260(13):8106-113
    • Latest
      J:262615 Yamashita Y, et al., Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 2018 May 17;8(1):7766

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory