Gene Expression Literature Summary

• Symbol: Hspg2
• Name: perlecan (heparan sulfate proteoglycan 2)
• ID: MGI:96257

128 matching records from 128 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3.5	E4	E4.5	E5	E5.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)			1	1	1	1	4	2	4	3	5	2	10	4	11	1	12	4	8	3	15	4	11		12	3	9		9	2	10			4	35
In situ RNA (section)	1	1	1						1				1		1				2	2	2	1	3		2	1	1		1	1				1	1
Immunohistochemistry (whole mount)			2	1		1	1	1															1								1			1	2
In situ RNA (whole mount)												1			1
Northern blot															1		1		1		1		1								1
Western blot																									1										2
RT-PCR		1	1												2	1		1	1	3	1	4	3	3	5	3	2	1		1		1	1		11
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hspg2  perlecan (heparan sulfate proteoglycan 2)   (Synonyms: Pcn, per, perlecan, Plc)
Results	Reference
1	J:245045 Aghajanian H, Cho YK, Rizer NW, Wang Q, Li L, Degenhardt K, Jain R, Pdgfralpha functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017 Sep 01;10(9):1101-1108
1	J:110553 Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J, WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem. 2006 Mar 17;281(11):7341-9
1	J:139369 Allen JM, Brachvogel B, Farlie PG, Fitzgerald J, Bateman JF, The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes. Matrix Biol. 2008 May;27(4):295-305
1	J:102740 Alpy F, Jivkov I, Sorokin L, Klein A, Arnold C, Huss Y, Kedinger M, Simon-Assmann P, Lefebvre O, Generation of a conditionally null allele of the laminin alpha1 gene. Genesis. 2005 Oct;43(2):59-70
1	J:153597 Anderson C, Thorsteinsdottir S, Borycki AG, Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Development. 2009 Oct;136(20):3495-504
1	J:74542 Arikawa-Hirasawa E, Rossi SG, Rotundo RL, Yamada Y, Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice. Nat Neurosci. 2002 Feb;5(2):119-23
1	J:67299 Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y, Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
1	J:297362 Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A, Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59
1	J:100029 Bader BL, Smyth N, Nedbal S, Miosge N, Baranowsky A, Mokkapati S, Murshed M, Nischt R, Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice. Mol Cell Biol. 2005 Aug;25(15):6846-56
1	J:108443 Bajanca F, Luz M, Raymond K, Martins GG, Sonnenberg A, Tajbakhsh S, Buckingham M, Thorsteinsdottir S, Integrin {alpha}6{beta}1-laminin interactions regulate early myotome formation in the mouse embryo. Development. 2006 May;133(9):1635-44
1	J:218940 Barnette DN, VandeKopple M, Wu Y, Willoughby DA, Lincoln J, RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. PLoS One. 2014;9(7):e101425
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4	J:117635 Bose K, Nischt R, Page A, Bader BL, Paulsson M, Smyth N, Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. J Biol Chem. 2006 Dec 22;281(51):39620-9
1	J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
2	J:175154 Brown AJ, Alicknavitch M, D'Souza SS, Daikoku T, Kirn-Safran CB, Marchetti D, Carson DD, Farach-Carson MC, Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008 Oct;43(4):689-99
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1	J:202949 Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J, Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
1*	J:286647 Chen CA, Wang W, Pedersen SE, Raman A, Seymour ML, Ruiz FR, Xia A, van der Heijden ME, Wang L, Yin J, Lopez J, Rech ME, Lewis RA, Wu SM, Liu Z, Pereira FA, Pautler RG, Zoghbi HY, Schaaf CP, Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Hum Mol Genet. 2020 Mar 27;29(5):705-715
1	J:248927 Clements R, Turk R, Campbell KP, Wright KM, Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017 Aug 30;37(35):8559-8574
1	J:266267 Clements R, Wright KM, Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan. Dev Biol. 2018 Oct 15;442(2):210-219
1	J:80720 Costell M, Carmona R, Gustafsson E, Gonzalez-Iriarte M, Fassler R, Munoz-Chapuli R, Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res. 2002 Jul 26;91(2):158-64
2	J:58700 Costell M, Gustafsson E, Aszodi A, Morgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fassler R, Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999 Nov 29;147(5):1109-22
1	J:342336 Davaapil H, Hopkins J, Bonnin N, Papadaki V, Leung A, Kosuge H, Tashima T, Nakakido M, Sekido R, Tsumoto K, Sagoo MS, Ohnuma SI, PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity. Front Cell Dev Biol. 2023;11:1147625
8	J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445
1*	J:116164 Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquie O, A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science. 2006 Dec 8;314(5805):1595-8
1	J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
1	J:230611 Dierker T, Bachvarova V, Krause Y, Li JP, Kjellen L, Seidler DG, Vortkamp A, Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biol. 2016 Jan;49:82-92
1	J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
2	J:315134 Ezan P, Andre P, Cisternino S, Saubamea B, Boulay AC, Doutremer S, Thomas MA, Quenech'du N, Giaume C, Cohen-Salmon M, Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012 Aug;32(8):1457-67
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1*	J:79225 Flugel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER, Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn. 2002 Oct;225(2):111-25
1*	J:83696 Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, Murphy M, Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn. 2003 Jun;227(2):170-84
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10*	J:55507 French MM, Smith SE, Akanbi K, Sanford T, Hecht J, Farach-Carson MC, Carson DD, Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro. J Cell Biol. 1999 May 31;145(5):1103-15
13*	J:227060 Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S, An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59(3):2553
1	J:167570 Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H, Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52
1	J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
1	J:95798 Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC, Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN. Circ Res. 2004 Feb 6;94(2):175-83
2*	J:98797 Gersdorff N, Muller M, Otto S, Poschadel R, Hubner S, Miosge N, Basement membrane composition in the early mouse embryo day 7. Dev Dyn. 2005 May 13;233(3):1140-1148
1	J:47014 Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH, Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998 Apr 1;17(7):1860-70
2	J:301041 Guo D, Ru J, Mao F, Ouyang H, Ju R, Wu K, Liu Y, Liu C, Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition. Development. 2020 Nov 30;147(22):dev191726
1	J:195888 Gustafsson E, Almonte-Becerril M, Bloch W, Costell M, Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. PLoS One. 2013;8(1):e53715
1	J:73993 Hall M, Gofflot F, Iseki S, Morriss-Kay GM, Effects of the curly tail genotype on neuroepithelial integrity and cell proliferation during late stages of primary neurulation. J Anat. 2001 Dec;199(Pt 6):645-55
3*	J:270680 Han X, Yoshizaki K, Miyazaki K, Arai C, Funada K, Yuta T, Tian T, Chiba Y, Saito K, Iwamoto T, Yamada A, Takahashi I, Fukumoto S, The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development. J Biol Chem. 2018 Sep 21;293(38):14572-14584
16*	J:43266 Handler M, Yurchenco PD, Iozzo RV, Developmental expression of perlecan during murine embryogenesis. Dev Dyn. 1997 Oct;210(2):130-45
2	J:311849 Hirata A, Katayama K, Tsuji T, Natsume N, Sugahara T, Koga Y, Takano K, Otsuki Y, Nakamura H, Heparanase localization during palatogenesis in mice. Biomed Res Int. 2013;2013:760236
2	J:227320 Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL, Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol. 2015 Jun 8;209(5):739-57
1	J:179356 Hu H, Li J, Gagen CS, Gray NW, Zhang Z, Qi Y, Zhang P, Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol. 2011 May 1;519(7):1320-37
7*	J:203017 Ida-Yonemochi H, Harada H, Ohshima H, Saku T, Reciprocal expressions between alpha-dystroglycan and integrin beta1, perlecan receptors, in the murine enamel organ development. Gene Expr Patterns. 2013 Dec;13(8):293-302
3	J:166656 Ida-Yonemochi H, Nakajima M, Saku T, Heparanase, heparan sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ. Arch Oral Biol. 2010 Oct;55(10):778-87
9	J:98778 Ida-Yonemochi H, Ohshiro K, Swelam W, Metwaly H, Saku T, Perlecan, a Basement Membrane-type Heparan Sulfate Proteoglycan, in the Enamel Organ: Its Intraepithelial Localization in the Stellate Reticulum. J Histochem Cytochem. 2005 Jun;53(6):763-72
1	J:134970 Inoue T, Ogawa M, Mikoshiba K, Aruga J, Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008 Apr 30;28(18):4712-25
1	J:188305 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y, Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 May;31(4):234-45
5	J:345111 Jacobson KR, Saleh AM, Lipp SN, Tian C, Watson AR, Luetkemeyer CM, Ocken AR, Spencer SL, Kinzer-Ursem TL, Calve S, Extracellular matrix protein composition dynamically changes during murine forelimb development. iScience. 2024 Feb 16;27(2):108838
6*	J:36833 Joseph SJ, Ford MD, Barth C, Portbury S, Bartlett PF, Nurcombe V , Greferath U, A proteoglycan that activates fibroblast growth factors during early neuronal development is a perlecan variant. Development. 1996 Nov;122(11):3443-52
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1	J:99700 Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K, Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp Cell Res. 2005 May 15;306(1):9-23
2*	J:111788 Kiyozumi D, Sugimoto N, Sekiguchi K, Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11981-6
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4	J:154365 Mikedis MM, Downs KM, Collagen type IV and Perlecan exhibit dynamic localization in the Allantoic Core Domain, a putative stem cell niche in the murine allantois. Dev Dyn. 2009 Nov 4;238(12):3193-3204
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1	J:320380 Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, van Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP, Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Matrix Biol. 2021 Sep;103-104:37-57
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3	J:91312 San Martin S, Soto-Suazo M, Zorn TM, Perlecan and Syndecan-4 in Uterine Tissues during the Early Pregnancy in Mice. Am J Reprod Immunol. 2004 Jul;52(1):53-9
2	J:161883 Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK, Perlecan is critical for heart stability. Cardiovasc Res. 2008 Dec 1;80(3):435-44
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