Hsp90aa1
Gene Detail

Symbol

Name
ID

Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
MGI:96250

Synonyms

hsp4, Hsp86-1, Hsp89, Hsp90, Hspca

Feature Type

protein coding gene

Genetic Map

Chromosome 12
60.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr12:110690605-110702728 bp, - strand From VEGA annotation of GRCm38   12124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:68464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: heat shock protein, HSP90/HTPG types
Gene Tree: Hsp90aa1

Human
homologs

Human Homolog		HSP90AA1, heat shock protein 90kDa alpha (cytosolic), class A member 1
NCBI Gene ID		3320
neXtProt AC		NX_P07900
Human Synonyms		EL52, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2
Human Chr (Location)		14q32.33; chr14:102080738-102139749 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(204) : Gene trapped(199) Targeted(4) Transgenic(1)
 

Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.

 

Interactions

Hsp90aa1 interacts with 168 markers (Mir7-1, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (67 annotations)

Process	chaperone-mediated protein complex assembly, neuron migration, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)

Data Summary: Results (267)    Tissues (61)    Images (36)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	255
Western blot	8
RT-PCR	4

cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(57) Genomic(7) cDNA(48) Primer pair(2)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000019766 (Evidence)
Ensembl Gene Model	ENSMUSG00000021270 (Evidence)
Entrez Gene	15519 (Evidence)
DFCI	TC1573620, TC1608529
NIA Mouse Gene Index	U034359, U114183, U135878, U155305
Consensus CDS Project	CCDS26172.1
International Mouse Knockout Project Status	Hsp90aa1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019766	VEGA Gene Model | MGI Sequence Detail	12124	C57BL/6J
transcript	OTTMUST00000047271	VEGA | MGI Sequence Detail	3281	Not Applicable
polypeptide	OTTMUSP00000021333	VEGA | MGI Sequence Detail	733	Not Applicable

All sequences(126) RefSeq(4) UniProt(25)

Polymorphisms

RFLP(1) : SNPs within 2kb(83 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001404	Heat shock protein Hsp90
InterPro	IPR019805	Heat shock protein Hsp90, conserved site
InterPro	IPR020575	Heat shock protein Hsp90, N-terminal
InterPro	IPR003594	Histidine kinase-like ATPase, ATP-binding domain
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
Protein Ontology	PR:000008799	heat shock protein HSP 90-alpha

References

(Earliest) J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
(Latest) J:203314 Erazo T, et al., Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86
All references(95)

Other
accession IDs

MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255