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Hsp90aa1
Gene Detail
Symbol

Name
ID
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
MGI:96250
Synonyms
hsp4, Hsp86-1, Hsp89, Hsp90, Hspca
Feature Type
protein coding gene
Genetic Map
Chromosome 12
60.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr12:110690605-110702728 bp, - strand
From VEGA annotation of GRCm38

  12124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HSP90AA1
Protein SuperFamily: heat shock protein, HSP90/HTPG types
Gene Tree: Hsp90aa1

Human
homologs
HSP90AA1, heat shock protein 90kDa alpha (cytosolic), class A member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3320
neXtProt AC: NX_P07900

Human Synonyms: EL52, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2

Human Chr (Location): 14q32.33; chr14:102080738-102139759 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(204) : Gene trapped(199) Targeted(4) Transgenic(1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.
 
Interactions
Hsp90aa1 interacts with 168 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process chaperone-mediated protein complex assembly, neuron migration, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (269)    Tissues (62)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 255
Western blot 8
RT-PCR 4
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hsp90aa1.1, hsp90aa1.2 ; ZFIN hsp90aa1.1, hsp90aa1.2    NEW 
Molecular
reagents
All nucleic(57) Genomic(7) cDNA(48) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019766 (Evidence)
Ensembl Gene Model ENSMUSG00000021270 (Evidence)
Entrez Gene 15519 (Evidence)
DFCI TC1573620, TC1608529
NIA Mouse Gene Index U034359, U114183, U135878, U155305
Consensus CDS Project CCDS26172.1
International Mouse Phenotyping Consortium Status Hsp90aa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019766 VEGA Gene Model | MGI Sequence Detail 12124 C57BL/6J ±  kb
transcript OTTMUST00000047271 VEGA | MGI Sequence Detail 3281 Not Applicable 
polypeptide OTTMUSP00000021333 VEGA | MGI Sequence Detail 733 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(2) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001404 Heat shock protein Hsp90
InterPro IPR019805 Heat shock protein Hsp90, conserved site
InterPro IPR020575 Heat shock protein Hsp90, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000008799 heat shock protein HSP 90-alpha
References
(Earliest) J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
(Latest) J:203314 Erazo T, et al., Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86
All references(93)
Other
accession IDs
MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory