Hsp90aa1 MGI Mouse Gene Detail - MGI:96250 - heat shock protein 90, alpha (cytosolic), class A member 1

Symbol

Hsp90aa1
Name

heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms

hsp4, Hsp86-1, Hsp89, Hsp90, Hspca

Feature Type

protein coding gene
IDs

MGI:96250
NCBI Gene: 15519
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:110657470-110662829 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.75 cM
Mapping Data

6 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

16
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96250	protein coding gene	Chr12:110657039-110669162 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020120	protein coding gene	Chr12:113010749-113022141 (-)
A/J	MGP_AJ_G0020074	protein coding gene	Chr12:108615834-108629861 (-)
AKR/J	MGP_AKRJ_G0020050	protein coding gene	Chr12:111799019-111804830 (-)
BALB/cJ	MGP_BALBcJ_G0020060	protein coding gene	Chr12:109101603-109114394 (-)
C3H/HeJ	MGP_C3HHeJ_G0019862	protein coding gene	Chr12:112254776-112267624 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020505	protein coding gene	Chr12:116459485-116469997 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018117	protein coding gene	Chr12:105131597-105137255 (-)
CAST/EiJ	MGP_CASTEiJ_G0019403	protein coding gene	Chr12:107134731-107148029 (-)
CBA/J	MGP_CBAJ_G0019829	protein coding gene	Chr12:121008544-121021654 (-)
DBA/2J	MGP_DBA2J_G0019946	protein coding gene	Chr12:108165699-108177545 (-)
FVB/NJ	MGP_FVBNJ_G0019931	protein coding gene	Chr12:106966189-106977380 (-)
LP/J	MGP_LPJ_G0020021	protein coding gene	Chr12:112838604-112853190 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019969	protein coding gene	Chr12:124124910-124139317 (-)
NZO/HlLtJ	no annotation
PWK/PhJ	MGP_PWKPhJ_G0019163	protein coding gene	Chr12:102791383-102803979 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0019461	protein coding gene	Chr12:112202040-112217869 (-)

Human Ortholog

HSP90AA1, heat shock protein 90 alpha family class A member 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSP90AA1, heat shock protein 90 alpha family class A member 1
Synonyms

EL52, HEL-S-65p, Hsp103, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP-2, LAP2
Links

HGNC:5253

NCBI Gene ID: 3320

UniProt: P07900
Chr Location

14q32.31; chr14:102080742-102139749 (-) GRCh38

Human Ortholog

HSP90AA4P, heat shock protein 90 alpha family class A member 4, pseudogene
Synonyms

HSP90Ad, HSPCAL2
Links

HGNC:5255

NCBI Gene ID: 3323

UniProt: Q58FG1
Chr Location

4q35.2; chr4:189472906-189475853 (+) GRCh38

MGI Vertebrate Homology

Hsp90aa1 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HSP90AA1, HSP90AA4P
Protein SuperFamily

Hsp90
Gene Tree

Hsp90aa1

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Phenotype Summary

34 phenotypes from 6 alleles in 8 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

73
Endonuclease-mediated

3
Gene trapped

64
Targeted

5
Transgenic

1
Incidental Mutations

CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.

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All GO Annotations

204
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1138
Tissues

202
cDNA Data

44
Literature Summary

33

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsp90aa1, hsp90aa1.2

ZFIN hsp90aa1.1, hsp90aa1.2

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All Sequences

112
RefSeq

2
UniProt

13
CCDS

CCDS26172.1

Ensembl

ENSMUSG00000021270 (Evidence)
NCBI Gene

15519

			Length	Strain/Species	Flank
genomic	15519	NCBI Gene Model \| MGI Sequence Detail	5360	C57BL/6J	± kb
transcript	NM_010480	RefSeq \| MGI Sequence Detail	2850	ZRU/MplStud
polypeptide	P07901	UniProt \| EBI \| MGI Sequence Detail	733	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000008799 heat shock protein HSP 90-alpha

(term hierarchy)
PDB

5H22, 7D1V, 7D22, 7D24, 7D25, 7D26
EC

3.6.4.10
InterPro Domains

IPR019805 Heat shock protein Hsp90, conserved site

IPR001404 Heat shock protein Hsp90 family

IPR020575 Heat shock protein Hsp90, N-terminal

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR037196 HSP90, C-terminal domain

IPR020568 Ribosomal protein uS5 domain 2-type superfamily
GlyGen

P07901 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 61

Genomic 7

cDNA 50

Primer pair 4

Microarray probesets 5

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MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255

Summaries

All 152

Developmental Gene Expression 33

Gene Ontology 25

Phenotypes 28
Earliest

J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
Latest

J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879

TSS for Hsp90aa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117792	Chr12:110662868-110662881 (-)	-46 bp
Tssr117791	Chr12:110662766-110662852 (-)	20 bp
Tssr117790	Chr12:110662743-110662753 (-)	81 bp
Tssr117789	Chr12:110662682-110662696 (-)	140 bp
Tssr117788	Chr12:110662294-110662310 (-)	527 bp
Tssr117787	Chr12:110662257-110662293 (-)	554 bp
Tssr117786	Chr12:110662198-110662242 (-)	609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24