Hsp90aa1 MGI Mouse Gene Detail - MGI:96250 - heat shock protein 90, alpha (cytosolic), class A member 1

Hsp90aa1 Gene Detail

Symbol

Hsp90aa1
Name

heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms

hsp4, Hsp86-1, Hsp89, Hsp90, Hspca

Feature Type

protein coding gene
IDs

MGI:96250
NCBI Gene: 15519

Sequence Map

Chr12:110690605-110702728 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

12124 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.75 cM
Mapping Data

6 experiments

Human Ortholog

HSP90AA1, heat shock protein 90 alpha family class A member 1

Vertebrate Orthologs

11

Human Ortholog

HSP90AA1, heat shock protein 90 alpha family class A member 1
Orthology source: HomoloGene, HGNC
Synonyms

EL52, HEL-S-65p, Hsp103, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2
Links

HGNC:5253

NCBI Gene ID: 3320

neXtProt AC: NX_P07900

UniProt: P07900
Chr Location

14q32.31; chr14:102080738-102139749 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68464
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HSP90AA1
Protein SuperFamily

heat shock protein, HSP90/HTPG types
Gene Tree

Hsp90aa1

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Phenotype Summary

18 phenotypes from 5 alleles in 6 genetic backgrounds
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

204
Gene trapped

199
Targeted

4
Transgenic

1
Incidental Mutations

CvDC
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.

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All GO Annotations

83
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

269
Tissues

62
cDNA Data

42
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hsp90aa1.1, hsp90aa1.2

ZFIN hsp90aa1.1, hsp90aa1.2

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Hsp90aa1 interacts with 168 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

111
RefSeq

2
UniProt

13
CCDS

CCDS26172.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000019766	VEGA Gene Model \| MGI Sequence Detail	12124	C57BL/6J	± kb
transcript	OTTMUST00000047272	VEGA \| MGI Sequence Detail	2852	Not Applicable
polypeptide	OTTMUSP00000021334	VEGA \| MGI Sequence Detail	733	Not Applicable

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SNPs within 2kb

82 from dbSNP Build 142

RFLP

1

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UniProt

13 Sequences
Protein Ontology

PR:000008799 heat shock protein HSP 90-alpha

(term hierarchy)
InterPro Domains

IPR019805 Heat shock protein Hsp90, conserved site

IPR001404 Heat shock protein Hsp90 family

IPR020575 Heat shock protein Hsp90, N-terminal

IPR003594 Histidine kinase-like ATPase, C-terminal domain

IPR020568 Ribosomal protein S5 domain 2-type fold

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All nucleic 57

Genomic 7

cDNA 48

Primer pair 2

Microarray probesets 5

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MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255

Summaries

All 93

Developmental Gene Expression 20

Gene Ontology 15

Phenotypes 15
Earliest

J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
Latest

J:231873 Mohamed BA, et al., Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014 Apr;50(4):817-24

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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