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Gene Detail
heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms hsp4, Hsp86-1, Hsp89, Hsp90, Hspca
Feature Type protein coding gene
Genetic Map
Chromosome 12
60.75 cM
Detailed Genetic Map ± 1 cM

Mapping data(6)
Sequence Map
Chr12:110690605-110702728 bp, - strand
From VEGA annotation of GRCm38

  12124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:68464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: heat shock protein, HSP90/HTPG types
Gene Tree: Hsp90aa1

Human Homolog HSP90AA1, heat shock protein 90kDa alpha (cytosolic), class A member 1
NCBI Gene ID 3320
neXtProt AC  NX_P07900
Human Synonyms  EL52, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2
Human Chr (Location)  14q32.33; chr14:102080738-102139749 (-)  GRCh38
alleles, and
All mutations/alleles(204) : Gene trapped(199) Targeted(4) Transgenic(1)
Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.
Hsp90aa1 interacts with 168 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
All GO classifications: (62 annotations)
Process ATP catabolic process, chaperone-mediated protein complex assembly, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Literature Summary: (19 records)
Data Summary: Results (267)    Tissues (61)    Images (36)
Theiler Stages: 1, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 255
Western blot 8
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(57) Genomic(7) cDNA(48) Primer pair(2)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000019766 (Evidence)
Ensembl Gene ModelENSMUSG00000021270 (Evidence)
Entrez Gene15519 (Evidence)
DFCITC1573620, TC1608529
NIA Mouse Gene IndexU034359, U114183, U135878, U155305
Consensus CDS ProjectCCDS26172.1
International Mouse Knockout Project StatusHsp90aa1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019766 VEGA Gene Model | MGI Sequence Detail 12124 C57BL/6J ±  kb
transcript OTTMUST00000047271 VEGA | MGI Sequence Detail 3281 Not Applicable 
polypeptide OTTMUSP00000021333 VEGA | MGI Sequence Detail 733 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(4) UniProt(13)
Polymorphisms RFLP(1) : SNPs within 2kb(83 from dbSNP Build 137)
InterPro IPR001404 Heat shock protein Hsp90
InterPro IPR019805 Heat shock protein Hsp90, conserved site
InterPro IPR020575 Heat shock protein Hsp90, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000008799 heat shock protein HSP 90-alpha
References (Earliest) J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
(Latest) J:203314 Erazo T, et al., Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86
All references(92)
accession IDs
MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory