About   Help   FAQ
Hsp90aa1 Gene Detail
Summary
  • Symbol
    Hsp90aa1
  • Name
    heat shock protein 90, alpha (cytosolic), class A member 1
  • Synonyms
    hsp4, Hsp86-1, Hsp89, Hsp90, Hspca
  • Feature Type
    protein coding gene
  • IDs
    MGI:96250
    NCBI Gene: 15519
Location & Maps
more
  • Sequence Map
    Chr12:110690605-110702728 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12124 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.75 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    HSP90AA1, heat shock protein 90 alpha family class A member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HSP90AA1, heat shock protein 90 alpha family class A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EL52, HEL-S-65p, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2
  • Links
    NCBI Gene ID: 3320
    neXtProt AC: NX_P07900

  • Chr Location
    14q32.33; chr14:102080738-102139759 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    204
  • Gene trapped
    199
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019766 VEGA Gene Model | MGI Sequence Detail 12124 C57BL/6J ±  kb
transcript OTTMUST00000047271 VEGA | MGI Sequence Detail 3281 Not Applicable  
polypeptide OTTMUSP00000021333 VEGA | MGI Sequence Detail 733 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000008799 heat shock protein HSP 90-alpha
  • InterPro Domains
    IPR019805 Heat shock protein Hsp90, conserved site
    IPR001404 Heat shock protein Hsp90 family
    IPR020575 Heat shock protein Hsp90, N-terminal
    IPR003594 Histidine kinase-like ATPase, C-terminal domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
Molecular
Reagents
less
  • All nucleic 57
    Genomic 7
    cDNA 48
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255
References
more
  • Summaries
    All 92
    Developmental Gene Expression 19
    Gene Ontology 15
    Phenotypes 15
  • Earliest
    J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
  • Latest
    J:214077 Bird JE, et al., Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12390-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory