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Hsp90aa1 Gene Detail
Summary
  • Symbol
    Hsp90aa1
  • Name
    heat shock protein 90, alpha (cytosolic), class A member 1
  • Synonyms
    hsp4, Hsp86-1, Hsp89, Hsp90, Hspca
  • Feature Type
    protein coding gene
  • IDs
    MGI:96250
    NCBI Gene: 15519
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110691036-110696395 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.75 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96250
 protein coding gene Chr12:110690605-110702728 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020120
 protein coding gene Chr12:113010749-113022141 (-)
A/J MGP_AJ_G0020074
 protein coding gene Chr12:108615834-108629861 (-)
AKR/J MGP_AKRJ_G0020050
 protein coding gene Chr12:111799019-111804830 (-)
BALB/cJ MGP_BALBcJ_G0020060
 protein coding gene Chr12:109101603-109114394 (-)
C3H/HeJ MGP_C3HHeJ_G0019862
 protein coding gene Chr12:112254776-112267624 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020505
 protein coding gene Chr12:116459485-116469997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018117
 protein coding gene Chr12:105131597-105137255 (-)
CAST/EiJ MGP_CASTEiJ_G0019403
 protein coding gene Chr12:107134731-107148029 (-)
CBA/J MGP_CBAJ_G0019829
 protein coding gene Chr12:121008544-121021654 (-)
DBA/2J MGP_DBA2J_G0019946
 protein coding gene Chr12:108165699-108177545 (-)
FVB/NJ MGP_FVBNJ_G0019931
 protein coding gene Chr12:106966189-106977380 (-)
LP/J MGP_LPJ_G0020021
 protein coding gene Chr12:112838604-112853190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019969
 protein coding gene Chr12:124124910-124139317 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019163
 protein coding gene Chr12:102791383-102803979 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019461
 protein coding gene Chr12:112202040-112217869 (-)



Homology
more
  • Human Ortholog
    HSP90AA1, heat shock protein 90 alpha family class A member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HSP90AA1, heat shock protein 90 alpha family class A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EL52, HEL-S-65p, Hsp103, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2, LAP-2
  • Links
    NCBI Gene ID: 3320
    neXtProt AC: NX_P07900
    UniProt: P07900

  • Chr Location
    14q32.31; chr14:102080738-102139749 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 8 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit male sterility associated with arrested male meiosis and male germ cell apoptosis. Mice homozygous for a transgenic gene disruption exhibit male sterility and small testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    120
  • cDNA Data
    44
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15519 NCBI Gene Model | MGI Sequence Detail 5360 C57BL/6J ±  kb
    transcript NM_010480 RefSeq | MGI Sequence Detail 2850 C57BL/6  
    polypeptide P07901 UniProt | EBI | MGI Sequence Detail 733 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 7
      cDNA 50
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10966, MGD-MRK-10973, MGD-MRK-10974, MGD-MRK-19409, MGI:2144927, MGI:2144928, MGI:96255
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 25
      Gene Ontology 20
      Phenotypes 18
    • Earliest
      J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
    • Latest
      J:300057 Morishita H, et al., Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder. Cell Rep. 2020 Dec 8;33(10):108477
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    03/30/2021
    MGI 6.16     		The Jackson Laboratory