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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
MGI:96250
34 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
involves: 129S4/SvJaeSor 		male infertility J:169871
Hsp90aa1Gt(XE444)Byg/Hsp90aa1Gt(XE444)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal male germ cell apoptosis J:169871
abnormal male meiosis J:169871
arrest of male meiosis J:169871
azoospermia J:169871
decreased testis weight J:169871
male infertility J:169871
normal reproductive system phenotype J:169871
small testis J:169871
Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
FVB/N-Hsp90aa1Tg(Tyr)2396BOve 		male infertility J:175597
small testis J:175597
Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
involves: C57BL/6 * FVB/N * FVB/NJ 		abnormal electroretinogram waveform feature J:283232
abnormal photoreceptor connecting cilium morphology J:283232
abnormal photoreceptor outer segment disc membrane morphology J:283232
abnormal photoreceptor outer segment morphology J:283232
abnormal retina photoreceptor morphology J:283232
blindness J:283232
decreased a-wave amplitude J:283232
decreased b-wave amplitude J:283232
increased retina apoptosis J:283232
photoreceptor inner segment degeneration J:283232
retina degeneration J:283232
retina photoreceptor degeneration J:283232
thin retina outer nuclear layer J:283232
Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi 		abnormal cranium morphology J:211773
abnormal incisor morphology J:211773
abnormal snout morphology J:211773
increased circulating alkaline phosphatase level J:211773
increased grip strength J:211773
male infertility J:211773
Hsp90aa1tm1.1Udon/Hsp90aa1tm1.1Udon
involves: C57BL/6 		abnormal dendritic cell antigen presentation J:177143
abnormal dendritic cell physiology J:177143
decreased interferon-gamma secretion J:177143
Hsp90aa1tm1.1Udon/Hsp90aa1tm1.1Udon
involves: C57BL/6 * FVB 		azoospermia J:187954
increased male germ cell apoptosis J:187954
male infertility J:187954
preweaning lethality, incomplete penetrance J:187954
normal reproductive system phenotype J:187954
small scrotum J:187954
small testis J:187954
Hsp90aa1tm1.2Udon/Hsp90aa1tm1.2Udon
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac * FVB/N 		abnormal male germ cell apoptosis J:187954
arrest of spermatogenesis J:187954
azoospermia J:187954
decreased testis weight J:187954
small testis J:187954
testicular atrophy J:187954
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory