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Hsp90ab1
Gene Detail
Symbol

Name
ID
Hsp90ab1
heat shock protein 90 alpha (cytosolic), class B member 1
MGI:96247
Synonyms
C81438, Hsp84, Hsp84-1, Hsp90, Hspcb
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:45567775-45573271 bp, - strand
From VEGA annotation of GRCm38

  5497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HSP90AB1
Protein SuperFamily: heat shock protein, HSP90/HTPG types
Gene Tree: Hsp90ab1

Human
homologs
HSP90AB1, heat shock protein 90kDa alpha (cytosolic), class B member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3326
neXtProt AC: NX_P08238

Human Synonyms: D6S182, HSP84, HSP90B, HSPC2, HSPCB

Human Chr (Location): 6p12; chr6:44246166-44253888 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(41) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation.
 
Interactions
Hsp90ab1 interacts with 35 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process cellular response to interleukin-4, fibril organization, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function ATP binding, CTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (104)    Tissues (78)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
Northern blot 12
cDNA source data(2020)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hsp90ab1 ; ZFIN hsp90ab1    NEW 
Molecular
reagents
All nucleic(2024) cDNA(2024)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020123 (Evidence)
Ensembl Gene Model ENSMUSG00000023944 (Evidence)
Entrez Gene 15516 (Evidence)
UniGene 2180
DFCI TC1573627, TC1722021
DoTS DT.101267508, DT.101375645, DT.102553556, DT.103578835, DT.110572127, DT.110572182, DT.110572214, DT.91365253, DT.94146926, DT.94236619, DT.97341668, DT.97368611, DT.99871780, DT.99872431
NIA Mouse Gene Index U037836, U293105
Consensus CDS Project CCDS28812.1
International Mouse Phenotyping Consortium Status Hsp90ab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020123 VEGA Gene Model | MGI Sequence Detail 5497 C57BL/6J ±  kb
transcript OTTMUST00000047842 VEGA | MGI Sequence Detail 2520 Not Applicable 
polypeptide OTTMUSP00000021764 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(2) UniProt(8)
Polymorphisms
RFLP(2) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001404 Heat shock protein Hsp90
InterPro IPR019805 Heat shock protein Hsp90, conserved site
InterPro IPR020575 Heat shock protein Hsp90, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000008800 heat shock protein HSP 90-beta
References
(Earliest) J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(88)
Other
accession IDs
MGD-MRK-10963, MGD-MRK-10974, MGI:2146951, MGI:2147140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory