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Hsp90ab1 Gene Detail
Summary
  • Symbol
    Hsp90ab1
  • Name
    heat shock protein 90 alpha (cytosolic), class B member 1
  • Synonyms
    C81438, Hsp84, Hsp84-1, Hsp90, Hspcb
  • Feature Type
    protein coding gene
  • IDs
    MGI:96247
    NCBI Gene: 15516
  • Gene Overview
    MyGene.info: HSP90AB1
Location & Maps
more
  • Sequence Map
    Chr17:45567775-45573271 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.59 cM
  • Mapping Data
    6 experiments
Homology
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  • Human Ortholog
    HSP90AB1, heat shock protein 90 alpha family class B member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSP90AB1, heat shock protein 90 alpha family class B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D6S182, HSP84, HSP90B, HSPC2, HSPCB
  • Links
    NCBI Gene ID: 3326
    neXtProt AC: NX_P08238

  • Chr Location
    6p21.1; chr6:44246166-44253888 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020123 VEGA Gene Model | MGI Sequence Detail 5497 C57BL/6J ±  kb
transcript OTTMUST00000047842 VEGA | MGI Sequence Detail 2520 Not Applicable  
polypeptide OTTMUSP00000021764 VEGA | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 2024
    cDNA 2024

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10963, MGD-MRK-10974, MGI:2146951, MGI:2147140
References
more
  • Summaries
    All 86
    Developmental Gene Expression 11
    Gene Ontology 17
    Phenotypes 11
  • Earliest
    J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
  • Latest
    J:228992 Nguyen MT, et al., Hsp90 chaperones PPARgamma and regulates differentiation and survival of 3T3-L1 adipocytes. Cell Death Differ. 2013 Dec;20(12):1654-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory