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Hspa1a Gene Detail
Summary
  • Symbol
    Hspa1a
  • Name
    heat shock protein 1A
  • Synonyms
    Hsp70-3, Hsp70.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96244
    NCBI Gene: 193740
  • Gene Overview
    MyGene.info: HSPA1A
Location & Maps
more
  • Sequence Map
    Chr17:34969190-34972156 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2967 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.51 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    HSPA1A, heat shock protein family A (Hsp70) member 1A
  • Vertebrate Orthologs
    13
  • Human Ortholog
    HSPA1A, heat shock protein family A (Hsp70) member 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-103, HSP70-1, HSP70.1, HSP70-1A, HSP70I, HSP72, HSPA1
  • Links
    NCBI Gene ID: 3303
    neXtProt AC: NX_P0DMV8, NX_P0DMV9

  • Chr Location
    6p21.33; chr6:31815514-31817942 (+)  GRCh38.p2

  • Human Ortholog
    HSPA1B, heat shock protein family A (Hsp70) member 1B
    Orthology source: HomoloGene
  • Synonyms
    HSP70-1B, HSP70-2, HSP70.2
  • Links
    NCBI Gene ID: 3304
    neXtProt AC: NX_P0DMV8, NX_P0DMV9

  • Chr Location
    6p21.33; chr6:31827735-31830254 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Hspa1a
  • Incidental Mutations
    APF , CvDC
At the cellular level, mice homozygous for a knock-out allele exhibit impaired thermotolerance and increased sensitivity to heat stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037921 VEGA Gene Model | MGI Sequence Detail 2967 C57BL/6J ±  kb
transcript OTTMUST00000097741 VEGA | MGI Sequence Detail 2967 Not Applicable  
polypeptide OTTMUSP00000054816 VEGA | MGI Sequence Detail 641 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    Genomic 16
    cDNA 39
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10960
References
more
  • Summaries
    All 64
    Developmental Gene Expression 8
    Gene Ontology 9
    Phenotypes 38
  • Earliest
    J:14783 Lowe DG, et al., Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs. J Biol Chem. 1986 Feb 15;261(5):2102-12
  • Latest
    J:231535 Zhou Y, et al., Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis. Am J Pathol. 2016 Apr;186(4):816-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory