About   Help   FAQ
Hspd1
Gene Detail
 Symbol
Name
ID
Hspd1
heat shock protein 1 (chaperonin)
MGI:96242
Synonyms Hsp60
Feature Type protein coding gene
Genetic Map
Chromosome 1
28.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:55077835-55088243 bp, - strand
From VEGA annotation of GRCm38

  10409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1626  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chaperonin GroEL
Gene Tree: Hspd1

Human
homologs
Human Homolog HSPD1, heat shock 60kDa protein 1 (chaperonin)
NCBI Gene ID 3329
neXtProt AC  NX_P10809
Human Synonyms  CPN60, GROEL, HLD4, HSP60, HSP-60, HSP65, HuCHA60, SPG13
Human Chr (Location)  2q33.1; chr2:197486584-197500274 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human HSPD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(65) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene-trap allele exhibit embryonic lethality between E7.5 and E9.75 associated with growth retardation. Males heterozygous for a gene-trap allele produce fewer female offspring than expected. Heterozygotes develop a slowly progressive motor defect resembling spastic paraplegia.
 
Human Diseases Modeled Using Mouse Hspd1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hspd1 interacts with 145 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, B cell activation, ...
Component cell surface, coated pit, ...
Function ATP binding, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (12)    Tissues (7)    Images (1)
Theiler Stages: 13, 15, 17, 18, 19, 20
Assay TypeResults
RNA in situ 4
Western blot 8
cDNA source data(364)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(365) cDNA(364) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021770 (Evidence)
Ensembl Gene ModelENSMUSG00000025980 (Evidence)
Entrez Gene15510 (Evidence)
UniGene1777
DFCITC1573756, TC1703585
DoTSDT.102552211, DT.102553326, DT.110536282, DT.110921961, DT.110922198, DT.91404265, DT.94376348, DT.99869689
NIA Mouse Gene IndexU021336, U068862, U111697
Consensus CDS ProjectCCDS35569.1
International Mouse Knockout Project StatusHspd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021770 VEGA Gene Model | MGI Sequence Detail 10409 C57BL/6J ±  kb
transcript OTTMUST00000051674 VEGA | MGI Sequence Detail 2423 Not Applicable 
polypeptide OTTMUSP00000024365 VEGA | MGI Sequence Detail 573 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
InterPro IPR001844 Chaperonin Cpn60
InterPro IPR018370 Chaperonin Cpn60, conserved site
InterPro IPR002423 Chaperonin Cpn60/TCP-1
InterPro IPR027409 GroEL-like apical domain
InterPro IPR027413 GroEL-like equatorial domain
Protein Ontology PR:000008824 60 kDa heat shock protein, mitochondrial
References (Earliest) J:10841 Venner TJ, et al., Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA. Biochim Biophys Acta. 1990 Nov 30;1087(3):336-8
(Latest) J:204433 Colley SM, et al., Loss of the nuclear receptor corepressor SLIRP compromises male fertility. PLoS One. 2013;8(8):e70700
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10957

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory