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Hspd1 Gene Detail
Summary
  • Symbol
    Hspd1
  • Name
    heat shock protein 1 (chaperonin)
  • Synonyms
    Hsp60
  • Feature Type
    protein coding gene
  • IDs
    MGI:96242
    NCBI Gene: 15510
  • Gene Overview
    MyGene.info: HSPD1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:55077834-55088217 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96242
protein coding gene Chr1:55077834-55088243 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016030
protein coding gene Chr1:54789070-54802128 (-)
A/J MGP_AJ_G0016013
protein coding gene Chr1:52884452-52895912 (-)
AKR/J MGP_AKRJ_G0015969
protein coding gene Chr1:54320167-54332923 (-)
BALB/cJ MGP_BALBcJ_G0015968
protein coding gene Chr1:52937913-52949205 (-)
C3H/HeJ MGP_C3HHeJ_G0015800
protein coding gene Chr1:54565009-54575464 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016421
protein coding gene Chr1:57052193-57072671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014143
protein coding gene Chr1:48980613-48991308 (-)
CAST/EiJ MGP_CASTEiJ_G0015382
protein coding gene Chr1:53840262-53855576 (-)
CBA/J MGP_CBAJ_G0015772
protein coding gene Chr1:58663810-58682581 (-)
DBA/2J MGP_DBA2J_G0015873
protein coding gene Chr1:52310473-52320923 (-)
FVB/NJ MGP_FVBNJ_G0015875
protein coding gene Chr1:51659045-51669219 (-)
LP/J MGP_LPJ_G0015945
protein coding gene Chr1:55616979-55628940 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015895
protein coding gene Chr1:61777013-61788750 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016468
protein coding gene Chr1:54270943-54281401 (-)
PWK/PhJ MGP_PWKPhJ_G0015168
protein coding gene Chr1:51674153-51684145 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014949
protein coding gene Chr1:53900355-53910622 (-)
WSB/EiJ MGP_WSBEiJ_G0015445
protein coding gene Chr1:53963848-53970316 (-)



Homology
more
  • Human Ortholog
    HSPD1, heat shock protein family D (Hsp60) member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPD1, heat shock protein family D (Hsp60) member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPN60, GROEL, HLD4, HSP60, HSP-60, HSP65, HuCHA60, SPG13
  • Links
    NCBI Gene ID: 3329
    neXtProt AC: NX_P10809
    UniProt: P10809

  • Chr Location
    2q33.1; chr2:197486584-197500274 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hspd1 mouse models; 2 with human HSPD1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trap allele exhibit embryonic lethality between E7.5 and E9.75 associated with growth retardation. Males heterozygous for a gene-trap allele produce fewer female offspring than expected. Heterozygotes develop a slowly progressive motor defect resembling spastic paraplegia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15510 NCBI Gene Model | MGI Sequence Detail 10384 C57BL/6J ±  kb
    transcript NM_001356512 RefSeq | MGI Sequence Detail 2434 C57BL/6  
    polypeptide P63038 UniProt | EBI | MGI Sequence Detail 573 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 366
      cDNA 365
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10957
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 30
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory