Hspd1
Gene Detail

Symbol Name ID

Hspd1 heat shock protein 1 (chaperonin) MGI:96242

Synonyms

Hsp60

Feature Type

protein coding gene

Genetic Map

Chromosome 1

28.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:55077835-55088243 bp, - strand From VEGA annotation of GRCm38   10409 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1626  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chaperonin GroEL
Gene Tree: Hspd1

Human homologs

Human Homolog		HSPD1, heat shock 60kDa protein 1 (chaperonin)
NCBI Gene ID		3329
neXtProt AC		NX_P10809
Human Synonyms		CPN60, GROEL, HLD4, HSP60, HSP-60, HSP65, HuCHA60, SPG13
Human Chr (Location)		2q33.1; chr2:198351308-198364998 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HSPD1

Alleles and phenotypes

All alleles(67) : Targeted(2) Gene trapped(65)
 

Mice homozygous for a gene-trap allele exhibit embryonic lethality between E7.5 and E9.75 associated with growth retardation. Male mice heterozygous for a gene-trap allele produce fewer female offspring than expected.

 

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, B cell activation, ...
Component	cell surface, coated pit, ...
Function	ATP binding, cell surface binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (12)    Tissues (7)    Images (1)
Theiler Stages: 13, 15, 17, 18, 19, 20

Assay Type	Results
RNA in situ	4
Western blot	8

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021770 (Evidence)
Ensembl Gene Model	ENSMUSG00000025980 (Evidence)
Entrez Gene	15510 (Evidence)
DFCI	TC1573756, TC1703585
DoTS	DT.102552211, DT.102553326, DT.110536282, DT.110921961, DT.110922198, DT.91404265, DT.94376348, DT.99869689
NIA Mouse Gene Index	U021336, U068862, U111697
Consensus CDS Project	CCDS35569.1
International Mouse Knockout Project Status	Hspd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021770	VEGA Gene Model | MGI Sequence Detail	10409	C57BL/6J
transcript	OTTMUST00000051674	VEGA | MGI Sequence Detail	2423	Not Applicable
polypeptide	OTTMUSP00000024365	VEGA | MGI Sequence Detail	573	Not Applicable

All sequences(69) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017998	Chaperone tailless complex polypeptide 1 (TCP-1)
InterPro	IPR001844	Chaperonin Cpn60
InterPro	IPR018370	Chaperonin Cpn60, conserved site
InterPro	IPR002423	Chaperonin Cpn60/TCP-1
Protein Ontology	PR:000008824	60 kDa heat shock protein, mitochondrial

References

(Earliest) J:10841 Venner TJ, et al., Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA. Biochim Biophys Acta. 1990 Nov 30;1087(3):336-8
(Latest) J:179027 Engl G, et al., Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012 Jan 15;21(2):287-99
All references(72)

Other accession IDs

MGD-MRK-10957