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Hsf1 Gene Detail
Summary
  • Symbol
    Hsf1
  • Name
    heat shock factor 1
  • Synonyms
    heat shock transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96238
    NCBI Gene: 15499
  • Gene Overview
    MyGene.info: HSF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:76477367-76500982 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23616 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.95 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSF1, heat shock transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSTF1
  • Links
    NCBI Gene ID: 3297
    neXtProt AC: NX_Q00613
    UniProt: Q00613

  • Chr Location
    8q24.3; chr8:144291588-144314722 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 5 alleles in 8 genetic backgrounds
    29 phenotypes from multigenic genotypes
    4 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15499 NCBI Gene Model | MGI Sequence Detail 23616 C57BL/6J ±  kb
    transcript NM_001331152 RefSeq | MGI Sequence Detail 2434 C57BL/6  
    polypeptide P38532 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      51 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000008790 heat shock factor protein 1
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR027725 Heat shock transcription factor family
      IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 6
      cDNA 63
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10952, MGI:2145933
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 14
      Phenotypes 107
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2017;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory