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Hsf1 Gene Detail
Summary
  • Symbol
    Hsf1
  • Name
    heat shock factor 1
  • Synonyms
    heat shock transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96238
    NCBI Gene: 15499
  • Gene Overview
    MyGene.info: HSF1
Location & Maps
more
  • Sequence Map
    Chr15:76477445-76500972 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23528 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.95 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSF1, heat shock transcription factor 1
    Orthology source: HomoloGene
  • Synonyms
    HSTF1
  • Links
    NCBI Gene ID: 3297
    neXtProt AC: NX_Q00613

  • Chr Location
    8q24.3; chr8:144291588-144314722 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    4 images
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    3
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    5 involving Hsf1
  • Incidental Mutations
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022556 Ensembl Gene Model | MGI Sequence Detail 23528 C57BL/6J ±  kb
transcript ENSMUST00000072838 Ensembl | MGI Sequence Detail 2018 Not Applicable  
polypeptide ENSMUSP00000072617 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008790 heat shock factor protein 1
  • InterPro Domains
    IPR000232 Heat shock factor (HSF)-type, DNA-binding
    IPR027072 Heat shock factor protein 1
    IPR027725 Heat shock transcription factor family
    IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 72
    Genomic 6
    cDNA 63
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10952, MGI:2145933
References
more
  • Summaries
    All 138
    Developmental Gene Expression 11
    Diseases 2
    Gene Ontology 14
    Phenotypes 101
  • Earliest
    J:12519 Bishop CE, et al., Comparative mapping of murine X and autosomal sequences homologous to the Human Y located testis determining region. Cytogenet Cell Genet. 1989;51:963 (Abstr. 2300)
  • Latest
    J:229693 Saito K, et al., Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015 Jul;45(7):2028-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory