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Hsf1
Gene Detail
Symbol

Name
ID
Hsf1
heat shock factor 1
MGI:96238
Synonyms
heat shock transcription factor 1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:76477445-76500972 bp, + strand
From NCBI annotation of GRCm38

  23528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heat shock transcription factor
Gene Tree: Hsf1

Human
homologs
Human Homolog HSF1, heat shock transcription factor 1
NCBI Gene ID 3297
neXtProt AC  NX_Q00613
Human Synonyms  HSTF1
Human Chr (Location)  8q24.3; chr8:144291588-144314722 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Radiation induced(1) Targeted(8)
Genomic Mutations involving Hsf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Hsf1 interacts with 43 markers (Mir18b, Mir92-1, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to heat, defense response, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (55)    Tissues (48)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
Western blot 9
RT-PCR 18
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) Genomic(6) cDNA(63) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022556 (Evidence)
Entrez Gene15499 (Evidence)
UniGene347444
DFCITC1580247, TC1601173, TC1604892, TC1608106, TC1616723
NIA Mouse Gene IndexU016371
Consensus CDS ProjectCCDS27572.1
International Mouse Knockout Project StatusHsf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15499 NCBI Gene Model | MGI Sequence Detail 23528 C57BL/6J ±  kb
transcript NM_008296 RefSeq | MGI Sequence Detail 2018 C57BL/6 
polypeptide P38532 UniProt | EBI | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
InterPro IPR027072 Heat shock factor protein 1
InterPro IPR010542 Vertebrate heat shock transcription factor
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008790 heat shock factor protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:12519 Bishop CE, et al., Comparative mapping of murine X and autosomal sequences homologous to the Human Y located testis determining region. Cytogenet Cell Genet. 1989;51:963 (Abstr. 2300)
(Latest) J:212502 Jego G, et al., Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia. 2014 Aug;28(8):1676-86
All references(131)
Other
accession IDs
MGD-MRK-10952, MGI:2145933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory