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Hsf1
Gene Detail
Symbol

Name
ID
Hsf1
heat shock factor 1
MGI:96238
Synonyms
heat shock transcription factor 1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:76477445-76500972 bp, + strand
From Ensembl annotation of GRCm38

  23528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HSF1
Protein SuperFamily: heat shock transcription factor
Gene Tree: Hsf1

Human
homologs
HSF1, heat shock transcription factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3297
neXtProt AC: NX_Q00613

Human Synonyms: HSTF1

Human Chr (Location): 8q24.3; chr8:144291588-144314722 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Radiation induced(1) Targeted(8)
Genomic Mutations involving Hsf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(6)
Interactions
Hsf1 interacts with 43 markers (Mir18b, Mir92-1, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to heat, defense response, ...
Component cytoplasm, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (55)    Tissues (48)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
Western blot 9
RT-PCR 18
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hsf1    NEW 
Molecular
reagents
All nucleic(72) Genomic(6) cDNA(63) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022556 (Evidence)
Entrez Gene 15499 (Evidence)
UniGene 347444
DFCI TC1580247, TC1601173, TC1604892, TC1608106, TC1616723
NIA Mouse Gene Index U016371
Consensus CDS Project CCDS27572.1
International Mouse Phenotyping Consortium Status Hsf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022556 Ensembl Gene Model | MGI Sequence Detail 23528 C57BL/6J ±  kb
transcript ENSMUST00000072838 Ensembl | MGI Sequence Detail 2018 Not Applicable 
polypeptide ENSMUSP00000072617 Ensembl | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
InterPro IPR027072 Heat shock factor protein 1
InterPro IPR027725 Heat shock transcription factor family
InterPro IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008790 heat shock factor protein 1
References
(Earliest) J:12519 Bishop CE, et al., Comparative mapping of murine X and autosomal sequences homologous to the Human Y located testis determining region. Cytogenet Cell Genet. 1989;51:963 (Abstr. 2300)
(Latest) J:217237 Chai RC, et al., Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. J Biol Chem. 2014 May 9;289(19):13602-14
All references(135)
Other
accession IDs
MGD-MRK-10952, MGI:2145933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory