Hsf1
Gene Detail

Symbol Name ID

Hsf1 heat shock factor 1 MGI:96238

Synonyms

heat shock transcription factor 1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

35.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:76477445-76500972 bp, + strand From NCBI annotation of GRCm38   23528 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: heat shock transcription factor
Gene Tree: Hsf1

Human homologs

Human Homolog		HSF1, heat shock transcription factor 1
NCBI Gene ID		3297
neXtProt AC		NX_Q00613
Human Synonyms		HSTF1
Human Chr (Location)		8q24.3; chr8:145515270-145538385 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(8) Gene trapped(4)
 

Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cellular response to heat, defense response, ...
Component	cytoplasm, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (62)    Tissues (52)    Images (4)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 26, 28

Assay Type	Results
RNA in situ	28
Western blot	9
RT-PCR	25

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(6) cDNA(63) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022556 (Evidence)
Entrez Gene	15499 (Evidence)
UniGene	347444
DFCI	TC1580247, TC1601173, TC1604892, TC1608106, TC1616723
NIA Mouse Gene Index	U016371
Consensus CDS Project	CCDS27572.1
International Mouse Knockout Project Status	Hsf1

Sequences

Length	Strain/Species
genomic	15499	NCBI Gene Model | MGI Sequence Detail	23528	C57BL/6J
transcript	NM_008296	RefSeq | MGI Sequence Detail	2018	C57BL/6
polypeptide	P38532	UniProt | EBI | MGI Sequence Detail	525	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000232	Heat shock factor (HSF)-type, DNA-binding
InterPro	IPR027072	Heat shock factor protein 1
InterPro	IPR010542	Vertebrate heat shock transcription factor
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000008790	heat shock factor protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:12519 Bishop CE, et al., Comparative mapping of murine X and autosomal sequences homologous to the Human Y located testis determining region. Cytogenet Cell Genet. 1989;51:963 (Abstr. 2300)
(Latest) J:191670 Dai C, et al., Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012 Oct 1;122(10):3742-54
All references(125)

Other accession IDs

MGD-MRK-10952, MGI:2145933