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Hp
Gene Detail
Symbol

Name
ID
Hp
haptoglobin
MGI:96211
Synonyms
HP-1, preHP2, zonulin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr8:109575130-109579172 bp, - strand
From Ensembl annotation of GRCm38

  4043 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:121756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HP
Protein SuperFamily: haptoglobin
Gene Tree: Hp

Human
homologs
HP, haptoglobin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3240
neXtProt AC: NX_P00738

Human Synonyms: BP, HP2ALPHA2, HPA1S

Human Chr (Location): 16q22.2; chr16:72054609-72061056 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HP

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygotes for a null allele exhibit partial postnatal lethality, susceptibility to induced acute hemolysis, and altered renal iron loading during aging and after ischemic injury. Homozygotes for a knock-in allele show reduced cholesterol efflux and enhanced nephropathy in STZ-induced diabetes.
 
Interactions
Hp interacts with 7 markers (Mir1b, Mir135b, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process acute-phase response, defense response to bacterium, ...
Component blood microparticle, endoplasmic reticulum, ...
Function antioxidant activity, hemoglobin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (78)    Tissues (29)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
Northern blot 39
RT-PCR 9
cDNA source data(304)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hp    NEW 
Molecular
reagents
All nucleic(313) Genomic(2) cDNA(308) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031722 (Evidence)
Entrez Gene 15439 (Evidence)
UniGene 26730
DFCI TC1573571
DoTS DT.536376
NIA Mouse Gene Index U030232
Consensus CDS Project CCDS40470.1
International Mouse Phenotyping Consortium Status Hp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031722 Ensembl Gene Model | MGI Sequence Detail 4043 C57BL/6J ±  kb
transcript ENSMUST00000074898 Ensembl | MGI Sequence Detail 1343 Not Applicable 
polypeptide ENSMUSP00000074436 Ensembl | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008292 Haptoglobin
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008725 haptoglobin
References
(Earliest) J:24824 Peacock AC, et al., Haptoglobin levels in serum of various strains of mice. Science. 1967 Dec 29;158(809):1703-4
(Latest) J:216822 Bertaggia E, et al., Haptoglobin is required to prevent oxidative stress and muscle atrophy. PLoS One. 2014;9(6):e100745
All references(76)
Other
accession IDs
MGD-MRK-10912

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory