Hp MGI Mouse Gene Detail - MGI:96211

Symbol

Hp
Name

haptoglobin
Synonyms

HP-1, preHP2, zonulin

Feature Type

protein coding gene
IDs

MGI:96211
NCBI Gene: 15439
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr8:110301760-110305804 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 57.11 cM
Mapping Data

20 experiments

SNPs within 2kb

39 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96211	protein coding gene	Chr8:110301760-110305804 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034108	protein coding gene	Chr8:112175288-112179330 (-)
A/J	MGP_AJ_G0034088	protein coding gene	Chr8:107617198-107621242 (-)
AKR/J	MGP_AKRJ_G0034014	protein coding gene	Chr8:110784339-110788383 (-)
BALB/cJ	MGP_BALBcJ_G0034081	protein coding gene	Chr8:107840440-107844482 (-)
C3H/HeJ	MGP_C3HHeJ_G0033793	protein coding gene	Chr8:111494486-111498531 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034601	protein coding gene	Chr8:116141141-116145183 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031543	protein coding gene	Chr8:100668861-100672757 (-)
CAST/EiJ	MGP_CASTEiJ_G0033120	protein coding gene	Chr8:111091232-111095248 (-)
CBA/J	MGP_CBAJ_G0033766	protein coding gene	Chr8:120036107-120040151 (-)
DBA/2J	MGP_DBA2J_G0033921	protein coding gene	Chr8:106957712-106961760 (-)
FVB/NJ	MGP_FVBNJ_G0033866	protein coding gene	Chr8:105907305-105911349 (-)
LP/J	MGP_LPJ_G0034012	protein coding gene	Chr8:112352313-112356357 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033911	protein coding gene	Chr8:123056883-123060927 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034620	protein coding gene	Chr8:110747089-110751132 (-)
PWK/PhJ	MGP_PWKPhJ_G0032822	protein coding gene	Chr8:106521037-106525069 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032661	protein coding gene	Chr8:109429872-109435500 (-)
WSB/EiJ	MGP_WSBEiJ_G0033235	protein coding gene	Chr8:111430601-111434645 (-)

Human Ortholog

HP, haptoglobin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HP, haptoglobin
Synonyms

BP, HP2ALPHA2, HPA1S
Links

HGNC:5141

NCBI Gene ID: 3240

neXtProt AC: NX_P00738

UniProt: P00738
Chr Location

16q22.2; chr16:72054505-72061055 (+) GRCh38

Human Ortholog

HPR, haptoglobin-related protein
Synonyms

A-259H10.2, HP
Links

HGNC:5156

NCBI Gene ID: 3250

neXtProt AC: NX_P00739

UniProt: P00739
Chr Location

16q22.2; chr16:72063148-72077246 (+) GRCh38

MGI Vertebrate Homology

Hp stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HP, HPR
Protein SuperFamily

Haptoglobin
Gene Tree

Hp

Diseases

9 with human HP associations

				Human Disease	Mouse Models
				arteriosclerosis IDs arteriosclerosis DOID:2349 ICD10CM:I70 MESH:D001161 NCI:C34398 UMLS_CUI:C0003850
				gout IDs gout DOID:13189 DOID:14144 EFO:0004274 ICD10CM:M10 ICD9CM:274 ICD9CM:274.0 ICD9CM:274.00 ICD9CM:274.9 MESH:D006073 MESH:D015210 NCI:C34650 UMLS_CUI:C0003868 UMLS_CUI:C0018099
				hemolytic anemia IDs hemolytic anemia DOID:583 ICD10CM:D55-D59 MESH:D000743 NCI:C34376 OMIM:266120 OMIM:612631 UMLS_CUI:C0002878
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				Plasmodium falciparum malaria IDs Plasmodium falciparum malaria DOID:14067 ICD10CM:B50 ICD9CM:084.0 ICD9CM_2006:084.0 MESH:D016778 NCI:C34798 UMLS_CUI:C0024535
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914
				pulmonary hypertension IDs pulmonary hypertension DOID:6432 ICD10CM:I27.20 MESH:D006976 NCI:C3120 UMLS_CUI:C0020542

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele exhibit partial postnatal lethality, susceptibility to induced acute hemolysis, and altered renal iron loading during aging and after ischemic injury. Homozygotes for a knock-in allele show reduced cholesterol efflux and enhanced nephropathy in STZ-induced diabetes.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

33
cDNA Data

305
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hp

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS40470.1

Ensembl

ENSMUSG00000031722 (Evidence)
NCBI Gene

15439

			Length	Strain/Species	Flank
genomic	15439	NCBI Gene Model \| MGI Sequence Detail	4045	C57BL/6J	± kb
transcript	NM_017370	RefSeq \| MGI Sequence Detail	1365	ZRU/MplStud
polypeptide	Q61646	UniProt \| EBI \| MGI Sequence Detail	347	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008725 haptoglobin

(term hierarchy)
InterPro Domains

IPR008292 Haptoglobin

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 315

Genomic 2

cDNA 309

Primer pair 2

Other 2

Microarray probesets 4

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MGD-MRK-10912

Summaries

All 92

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 33
Earliest

J:24824 Peacock AC, et al., Haptoglobin levels in serum of various strains of mice. Science. 1967 Dec 29;158(809):1703-4
Latest

J:298504 Kerchberger VE, et al., Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. JCI Insight. 2019 Nov 1;4(21)

TSS for Hp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82850	Chr8:110305688-110305704 (-)	108 bp
Tssr82849	Chr8:110305672-110305687 (-)	124 bp
Tssr82848	Chr8:110305415-110305419 (-)	387 bp
Tssr82847	Chr8:110304167-110304204 (-)	1,618 bp
Tssr82846	Chr8:110304142-110304161 (-)	1,652 bp
Tssr82845	Chr8:110303845-110303870 (-)	1,946 bp
Tssr82844	Chr8:110303790-110303844 (-)	1,987 bp
Tssr82843	Chr8:110303394-110303415 (-)	2,399 bp
Tssr82842	Chr8:110303374-110303393 (-)	2,420 bp
Tssr82841	Chr8:110302574-110302632 (-)	3,201 bp
Tssr82840	Chr8:110302552-110302563 (-)	3,246 bp
Tssr82839	Chr8:110302405-110302428 (-)	3,387 bp
Tssr82838	Chr8:110302392-110302402 (-)	3,407 bp
Tssr82837	Chr8:110302302-110302385 (-)	3,460 bp
Tssr82836	Chr8:110302232-110302272 (-)	3,552 bp
Tssr82835	Chr8:110302116-110302128 (-)	3,682 bp
Tssr82834	Chr8:110302030-110302047 (-)	3,765 bp
Tssr82833	Chr8:110301985-110302000 (-)	3,811 bp
Tssr82832	Chr8:110301818-110301831 (-)	3,979 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23