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Hp
Gene Detail
 Symbol
Name
ID
Hp
haptoglobin
MGI:96211
Synonyms HP-1, preHP2, zonulin
Feature Type protein coding gene
Genetic Map
Chromosome 8
57.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr8:109575130-109579172 bp, - strand
From Ensembl annotation of GRCm38

  4043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: haptoglobin
Gene Tree: Hp

Human
homologs
Human Homolog HP, haptoglobin
NCBI Gene ID 3240
neXtProt AC  NX_P00738
Human Synonyms  BP, HP2ALPHA2, HPA1S
Human Chr (Location)  16q22.2; chr16:72054566-72061056 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HP
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a null allele exhibit partial postnatal lethality, susceptibility to induced acute hemolysis, and altered renal iron loading during aging and after ischemic injury. Homozygotes for a knock-in allele show reduced cholesterol efflux and enhanced nephropathy in STZ-induced diabetes.
 
Interactions
Hp interacts with 7 markers (Mir1b, Mir135b, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process acute-phase response, defense response to bacterium, ...
Component blood microparticle, endoplasmic reticulum, ...
Function antioxidant activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (78)    Tissues (29)    Images (24)
Theiler Stages: 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 30
Northern blot 39
RT-PCR 9
cDNA source data(304)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(313) Genomic(2) cDNA(308) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031722 (Evidence)
Entrez Gene15439 (Evidence)
UniGene26730
DFCITC1573571
DoTSDT.536376
NIA Mouse Gene IndexU030232
Consensus CDS ProjectCCDS40470.1
International Mouse Knockout Project StatusHp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031722 Ensembl Gene Model | MGI Sequence Detail 4043 C57BL/6J ±  kb
transcript ENSMUST00000074898 Ensembl | MGI Sequence Detail 1343 Not Applicable 
polypeptide ENSMUSP00000074436 Ensembl | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008292 Haptoglobin
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008725 haptoglobin
References (Earliest) J:24824 Peacock AC, et al., Haptoglobin levels in serum of various strains of mice. Science. 1967 Dec 29;158(809):1703-4
(Latest) J:202795 Rittirsch D, et al., Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L863-72
All references(77)
Other
accession IDs
MGD-MRK-10912

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory