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Hp Gene Detail
Summary
  • Symbol
    Hp
  • Name
    haptoglobin
  • Synonyms
    HP-1, preHP2, zonulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96211
    NCBI Gene: 15439
  • Gene Overview
    MyGene.info: HP
Location & Maps
more
  • Sequence Map
    Chr8:109575130-109579172 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4043 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.11 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    HP, haptoglobin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HP, haptoglobin
    Orthology source: HomoloGene
  • Synonyms
    BP, HP2ALPHA2, HPA1S
  • Links
    NCBI Gene ID: 3240
    neXtProt AC: NX_P00738

  • Chr Location
    16q22.2; chr16:72054609-72061056 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HP associations

Human Disease Mouse Models
       Anhaptoglobinemia; AHP   OMIM: 614081
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Incidental Mutations
    APF
Homozygotes for a null allele exhibit partial postnatal lethality, susceptibility to induced acute hemolysis, and altered renal iron loading during aging and after ischemic injury. Homozygotes for a knock-in allele show reduced cholesterol efflux and enhanced nephropathy in STZ-induced diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031722 Ensembl Gene Model | MGI Sequence Detail 4043 C57BL/6J ±  kb
transcript ENSMUST00000074898 Ensembl | MGI Sequence Detail 1343 Not Applicable  
polypeptide ENSMUSP00000074436 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 313
    Genomic 2
    cDNA 308
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10912
References
more
  • Summaries
    All 73
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:24824 Peacock AC, et al., Haptoglobin levels in serum of various strains of mice. Science. 1967 Dec 29;158(809):1703-4
  • Latest
    J:216822 Bertaggia E, et al., Haptoglobin is required to prevent oxidative stress and muscle atrophy. PLoS One. 2014;9(6):e100745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory