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Hoxc8
Gene Detail
Symbol

Name
ID
Member of
Hoxc8
homeobox C8
MGI:96198
Hoxc cluster
STS
Synonyms
D130011F21Rik, Hox-3.1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
58.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr15:102990607-102994111 bp, + strand
From VEGA annotation of GRCm38

  3505 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130642  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A7
Gene Tree: Hoxc8

Human
homologs
Human Homolog HOXC8, homeobox C8
NCBI Gene ID 3224
neXtProt AC  NX_P31273
Human Synonyms  HOX3, HOX3A
Human Chr (Location)  12q13.3; chr12:54009106-54012763 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Radiation induced(1) Targeted(9)
Genomic Mutations involving Hoxc8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele exhibit abnormal growth and axial skeleton morphology. Mice homozygous for a knock-out allele exhibit postnatal lethality, axial skeletal defects, abnormal growth, and abnormal gait.
 
Interactions
Hoxc8 interacts with 267 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterior/posterior pattern specification, multicellular organismal development, ...
Component microtubule cytoskeleton, nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (563)    Tissues (359)    Images (107)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 440
In situ reporter (knock in) 20
Northern blot 36
RT-PCR 55
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(20) cDNA(34) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037398 (Evidence)
Ensembl Gene ModelENSMUSG00000001657 (Evidence)
Entrez Gene15426 (Evidence)
UniGene6167
DFCITC1588857, TC1622291, TC1641783
DoTSDT.94367552
NIA Mouse Gene IndexU016733, U377054
Consensus CDS ProjectCCDS27894.1
International Mouse Knockout Project StatusHoxc8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037398 VEGA Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
transcript OTTMUST00000096501 VEGA | MGI Sequence Detail 1868 Not Applicable 
polypeptide OTTMUSP00000053927 VEGA | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(5) : SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008714 homeobox protein Hox-C8
References
(Earliest) J:8243 Awgulewitsch A, et al., Spatial restriction in expression of a mouse homoeo box locus within the central nervous system. Nature. 1986 Mar 27-Apr 2;320(6060):328-35
(Latest) J:211197 Nishimoto S, et al., A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. PLoS Genet. 2014 Mar;10(3):e1004245
All references(142)
Other
accession IDs
MGD-MRK-10839, MGD-MRK-10899, MGI:2445105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory