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Hoxc8 Gene Detail
Summary
  • Symbol
    Hoxc8
  • Name
    homeobox C8
  • Synonyms
    D130011F21Rik, Hox-3.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96198
    NCBI Gene: 15426
  • Member of
    Hoxc cluster
  • Gene Overview
    MyGene.info: HOXC8
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102990607-102994111 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.05 cM
  • Mapping Data
    11 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96198
protein coding gene Chr15:102990539-102994254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022430
protein coding gene Chr15:105225926-105229430 (+)
A/J MGP_AJ_G0022392
protein coding gene Chr15:101069729-101073213 (+)
AKR/J MGP_AKRJ_G0022367
protein coding gene Chr15:104138448-104141934 (+)
BALB/cJ MGP_BALBcJ_G0022396
protein coding gene Chr15:101117046-101120550 (+)
C3H/HeJ MGP_C3HHeJ_G0022163
protein coding gene Chr15:104216977-104220467 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022845
protein coding gene Chr15:109121710-109125214 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020368
protein coding gene Chr15:96838977-96842487 (+)
CAST/EiJ MGP_CASTEiJ_G0021689
protein coding gene Chr15:105092257-105095756 (+)
CBA/J MGP_CBAJ_G0022132
protein coding gene Chr15:112957241-112960746 (+)
DBA/2J MGP_DBA2J_G0022263
protein coding gene Chr15:100339970-100343456 (+)
FVB/NJ MGP_FVBNJ_G0022239
protein coding gene Chr15:99409291-99412777 (+)
LP/J MGP_LPJ_G0022332
protein coding gene Chr15:105362541-105366045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022261
protein coding gene Chr15:116470921-116474407 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022857
protein coding gene Chr15:104177285-104180770 (+)
PWK/PhJ MGP_PWKPhJ_G0021429
protein coding gene Chr15:100519876-100523443 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021261
protein coding gene Chr15:104008695-104012199 (+)
WSB/EiJ MGP_WSBEiJ_G0021739
protein coding gene Chr15:104792215-104795700 (+)



Homology
more
  • Human Ortholog
    HOXC8, homeobox C8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXC8, homeobox C8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX3, HOX3A
  • Links
    NCBI Gene ID: 3224
    neXtProt AC: NX_P31273
    UniProt: P31273

  • Chr Location
    12q13.13; chr12:54009106-54012763 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 7 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit abnormal growth and axial skeleton morphology. Mice homozygous for a knock-out allele exhibit postnatal lethality, axial skeletal defects, abnormal growth, and abnormal gait.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001657 Ensembl Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
    transcript ENSMUST00000001703 Ensembl | MGI Sequence Detail 1868 Not Applicable  
    polypeptide ENSMUSP00000001703 Ensembl | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 20
      cDNA 40
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10839, MGD-MRK-10899, MGI:2445105
    References
    more
    • Summaries
      All 179
      Developmental Gene Expression 104
      Diseases 1
      Gene Ontology 8
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:277285 Baek M, et al., Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity. Cell Rep. 2019 May 28;27(9):2620-2635.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/05/2019
    MGI 6.14
    The Jackson Laboratory