Hoxb6
Gene Detail

Symbol Name ID

Hoxb6 homeobox B6 MGI:96187

Synonyms

Hox-2.2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:96292476-96301568 bp, + strand From VEGA annotation of GRCm38   9093 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Hoxb6

Human homologs

Human Homolog		HOXB6, homeobox B6
NCBI Gene ID		3216
neXtProt AC		NX_P17509
Human Synonyms		HOX2, Hox-2.2, HOX2B, HU-2
Human Chr (Location)		17q21.3; chr17:46673099-46682343 (-)  GRCh37.p13

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	anterior/posterior pattern specification, embryonic skeletal system development, ...
Component	nucleus
Function	DNA binding, poly(A) RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (60 records)

Data Summary: Results (325)    Tissues (165)    Images (52)
Theiler Stages: 2, 3, 4, 5, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28

Assay Type	Results
RNA in situ	175
Northern blot	8
RT-PCR	133
RNase protection	9

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(11) cDNA(16) Primer pair(6) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000001988 (Evidence)
Ensembl Gene Model	ENSMUSG00000000690 (Evidence)
Entrez Gene	15414 (Evidence)
UniGene	215
DFCI	TC1586347
DoTS	DT.101362488, DT.55209510
Consensus CDS Project	CCDS25295.1
International Mouse Knockout Project Status	Hoxb6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001988	VEGA Gene Model | MGI Sequence Detail	9093	C57BL/6J
transcript	OTTMUST00000096487	VEGA | MGI Sequence Detail	1537	Not Applicable
polypeptide	OTTMUSP00000053914	VEGA | MGI Sequence Detail	224	Not Applicable

All sequences(24) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(4) : SNPs within 2kb(44 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR017995	Homeobox protein, antennapedia type
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008703	homeobox protein Hox-B6

References

(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:196334 Harima Y, et al., Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep. 2013 Jan 31;3(1):1-7
All references(100)

Other accession IDs

MGD-MRK-10830, MGD-MRK-10888