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Hoxb6
Gene Detail
Symbol

Name
ID
Member of
Hoxb6
homeobox B6
MGI:96187
Hoxb cluster
Synonyms
Hox-2.2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:96292476-96301569 bp, + strand
From VEGA annotation of GRCm38

  9094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HOXB6
Gene Tree: Hoxb6

Human
homologs
HOXB6, homeobox B6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3216
neXtProt AC: NX_P17509

Human Synonyms: HOX2, Hox-2.2, HOX2B, HU-2

Human Chr (Location): 17q21.3; chr17:48594095-48604992 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Hoxb6 (2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.
 
Interactions
Hoxb6 interacts with 103 markers (Mir19a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system development, ...
Component nucleus
Function DNA binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (318)    Tissues (168)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 175
Northern blot 8
RT-PCR 126
RNase protection 9
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hoxb6 ; ZFIN hoxb6a, hoxb6b    NEW 
Molecular
reagents
All nucleic(34) Genomic(11) cDNA(16) Primer pair(6) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000001988 (Evidence)
Ensembl Gene Model ENSMUSG00000000690 (Evidence)
Entrez Gene 15414 (Evidence)
UniGene 215
DFCI TC1586347
DoTS DT.101362488, DT.55209510
Consensus CDS Project CCDS25295.1
International Mouse Phenotyping Consortium Status Hoxb6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001988 VEGA Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
transcript OTTMUST00000096486 VEGA | MGI Sequence Detail 1964 Not Applicable 
polypeptide OTTMUSP00000053913 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008703 homeobox protein Hox-B6
References
(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(98)
Other
accession IDs
MGD-MRK-10830, MGD-MRK-10888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory