Hoxb6 MGI Mouse Gene Detail - MGI:96187

Hoxb6 Gene Detail

Symbol

Hoxb6
Name

homeobox B6
Synonyms

Hox-2.2

Feature Type

protein coding gene
IDs

MGI:96187
NCBI Gene: 15414
Member of

Hoxb cluster
Gene Overview

MyGene.info: HOXB6
Alliance

gene page

Sequence Map

Chr11:96292476-96301569 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

9094 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.82 cM
Mapping Data

7 experiments

Human Ortholog

HOXB6, homeobox B6

Vertebrate Orthologs

10

Human Ortholog

HOXB6, homeobox B6
Orthology source: HomoloGene, HGNC
Synonyms

HOX2, Hox-2.2, HOX2B, HU-2
Links

HGNC:5117

NCBI Gene ID: 3216

neXtProt AC: NX_P17509

UniProt: P17509
Chr Location

17q21.32; chr17:48595736-48604992 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7366
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: HOXB6
Gene Tree

Hoxb6

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

1
Targeted

7
Genomic Mutations

3 involving Hoxb6
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available

Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.

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All GO Annotations

19
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

480
Tissues

244
cDNA Data

18
Literature Summary

68

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hoxb6a, hoxb6b

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Hoxb6 interacts with 103 markers (Mir19a, Mir23a, Mir23b, ...) View All

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All Sequences

19
RefSeq

4
UniProt

1
CCDS

CCDS25295.1
UniGene

215

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001988	VEGA Gene Model \| MGI Sequence Detail	9094	C57BL/6J	± kb
transcript	OTTMUST00000096486	VEGA \| MGI Sequence Detail	1964	Not Applicable
polypeptide	OTTMUSP00000053913	VEGA \| MGI Sequence Detail	224	Not Applicable

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SNPs within 2kb

43 from dbSNP Build 142

RFLP

4

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UniProt

1 Sequence
Protein Ontology

PR:000008703 homeobox protein Hox-B6

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR017995 Homeobox protein, antennapedia type

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 40

Genomic 12

cDNA 18

Primer pair 7

Other 3

Microarray probesets 2

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MGD-MRK-10830, MGD-MRK-10888

Summaries

All 112

Developmental Gene Expression 68

Gene Ontology 7

Phenotypes 19
Earliest

J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
Latest

J:239985 Casaca A, et al., Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity. Development. 2016 Feb 01;143(3):437-48

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/10/2017 MGI 6.10