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Hoxb6 Gene Detail
Summary
  • Symbol
    Hoxb6
  • Name
    homeobox B6
  • Synonyms
    Hox-2.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96187
    NCBI Gene: 15414
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB6
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:96292476-96301569 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9094 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.82 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    HOXB6, homeobox B6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXB6, homeobox B6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX2, Hox-2.2, HOX2B, HU-2
  • Links
    NCBI Gene ID: 3216
    neXtProt AC: NX_P17509
    UniProt: P17509

  • Chr Location
    17q21.32; chr17:48595736-48604992 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    480
  • Tissues
    244
  • cDNA Data
    18
  • Literature Summary
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001988 VEGA Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
    transcript OTTMUST00000096486 VEGA | MGI Sequence Detail 1964 Not Applicable  
    polypeptide OTTMUSP00000053913 VEGA | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      43 from dbSNP Build 142
    • RFLP
      4
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 12
      cDNA 18
      Primer pair 7
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10830, MGD-MRK-10888
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 73
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory