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Hoxb6 Gene Detail
Summary
  • Symbol
    Hoxb6
  • Name
    homeobox B6
  • Synonyms
    Hox-2.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96187
    NCBI Gene: 15414
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB6
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96292814-96301569 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.82 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96187
protein coding gene Chr11:96292476-96301569 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019004
protein coding gene Chr11:98604290-98613276 (+)
A/J MGP_AJ_G0018972
protein coding gene Chr11:94577132-94586180 (+)
AKR/J MGP_AKRJ_G0018942
protein coding gene Chr11:97503035-97512269 (+)
BALB/cJ MGP_BALBcJ_G0018945
protein coding gene Chr11:95076808-95085853 (+)
C3H/HeJ MGP_C3HHeJ_G0018759
protein coding gene Chr11:97634875-97643566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019397
protein coding gene Chr11:101686831-101695834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017027
protein coding gene Chr11:92063701-92072725 (+)
CAST/EiJ MGP_CASTEiJ_G0018312
protein coding gene Chr11:98456504-98465592 (+)
CBA/J MGP_CBAJ_G0018730
protein coding gene Chr11:105848315-105857646 (+)
DBA/2J MGP_DBA2J_G0018838
protein coding gene Chr11:94144240-94153602 (+)
FVB/NJ MGP_FVBNJ_G0018827
protein coding gene Chr11:93623238-93632341 (+)
LP/J MGP_LPJ_G0018908
protein coding gene Chr11:99141758-99150773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018854
protein coding gene Chr11:105844390-105853310 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019437
protein coding gene Chr11:97810668-97819790 (+)
PWK/PhJ MGP_PWKPhJ_G0018084
protein coding gene Chr11:95095687-95104924 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017873
protein coding gene Chr11:97536465-97546252 (+)
WSB/EiJ MGP_WSBEiJ_G0018362
protein coding gene Chr11:97696109-97706071 (+)



Homology
more
  • Human Ortholog
    HOXB6, homeobox B6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXB6, homeobox B6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX2, Hox-2.2, HOX2B, HU-2
  • Links
    NCBI Gene ID: 3216
    neXtProt AC: NX_P17509
    UniProt: P17509

  • Chr Location
    17q21.32; chr17:48595736-48604992 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15414 NCBI Gene Model | MGI Sequence Detail 8756 C57BL/6J ±  kb
    transcript NM_008269 RefSeq | MGI Sequence Detail 1435 C57BL/6  
    polypeptide P09023 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 12
      cDNA 19
      Primer pair 7
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10830, MGD-MRK-10888
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 75
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory