Hoxb6
Gene Detail

Symbol

Name
ID
Member of

Hoxb6
homeobox B6
MGI:96187
Hoxb cluster

Synonyms

Hox-2.2

Feature Type

protein coding gene

Genetic Map

Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr11:96292476-96301569 bp, + strand From VEGA annotation of GRCm38   9094 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Hoxb6

Human
homologs

Human Homolog		HOXB6, homeobox B6
NCBI Gene ID		3216
neXtProt AC		NX_P17509
Human Synonyms		HOX2, Hox-2.2, HOX2B, HU-2
Human Chr (Location)		17q21.3; chr17:48594095-48604992 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Hoxb6 (2)
Incidental mutations (data from APF )
 

Homozygotes for a targeted null mutation exhibit an anteriorizing homeotic transformation of the cervicothoracic vertebrae C6-T1, and frequently a missing first rib and a bifid second rib.

 

Interactions

Hoxb6 interacts with 103 markers (Mir19a, Mir23a, Mir23b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	anterior/posterior pattern specification, embryonic skeletal system development, ...
Component	nucleus
Function	DNA binding, poly(A) RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (61 records)

Data Summary: Results (318)    Tissues (168)    Images (52)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	175
Northern blot	8
RT-PCR	126
RNase protection	9

cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(34) Genomic(11) cDNA(16) Primer pair(6) Other(1)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000001988 (Evidence)
Ensembl Gene Model	ENSMUSG00000000690 (Evidence)
Entrez Gene	15414 (Evidence)
UniGene	215
DFCI	TC1586347
DoTS	DT.101362488, DT.55209510
Consensus CDS Project	CCDS25295.1
International Mouse Knockout Project Status	Hoxb6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001988	VEGA Gene Model | MGI Sequence Detail	9094	C57BL/6J
transcript	OTTMUST00000096486	VEGA | MGI Sequence Detail	1964	Not Applicable
polypeptide	OTTMUSP00000053913	VEGA | MGI Sequence Detail	224	Not Applicable

All sequences(22) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(4) : SNPs within 2kb(44 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR017995	Homeobox protein, antennapedia type
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008703	homeobox protein Hox-B6

References

(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(100)

Other
accession IDs

MGD-MRK-10830, MGD-MRK-10888