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Hoxb5
Gene Detail
Symbol

Name
ID
Member of
Hoxb5
homeobox B5
MGI:96186
Hoxb cluster
Synonyms
Hox-2.1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:96303336-96306121 bp, + strand
From VEGA annotation of GRCm38

  2786 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HOXB5
Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb5

Human
homologs
HOXB5, homeobox B5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3215
neXtProt AC: NX_P09067

Human Synonyms: HHO.C10, HOX2, Hox2.1, HOX2A, HU-1

Human Chr (Location): 17q21.3; chr17:48591257-48593741 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Hoxb5 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable and fertile but exhibit a rostral shift of the shoulder girdle resulting in altered position of the forelimbs, and show variable anteriorizing homeotic transformations of cervicothoracic vertrebrae C6 through T1.
 
Interactions
Hoxb5 interacts with 154 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (69 records)
Data Summary: Results (355)    Tissues (236)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 51
RNA in situ 181
Northern blot 16
Western blot 4
RT-PCR 78
RNase protection 25
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXB5 ; Xenbase hoxb5 ; ZFIN hoxb5a, hoxb5b    NEW 
Molecular
reagents
All nucleic(60) Genomic(17) cDNA(37) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001987 (Evidence)
Ensembl Gene Model ENSMUSG00000038700 (Evidence)
Entrez Gene 15413 (Evidence)
UniGene 207
DFCI TC1582898, TC1607754
DoTS DT.490141, DT.91311209
Consensus CDS Project CCDS25296.1
International Mouse Phenotyping Consortium Status Hoxb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001987 VEGA Gene Model | MGI Sequence Detail 2786 C57BL/6J ±  kb
transcript OTTMUST00000003992 VEGA | MGI Sequence Detail 1895 Not Applicable 
polypeptide OTTMUSP00000001930 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008702 homeobox protein Hox-B5
References
(Earliest) J:8076 Jackson IJ, et al., A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature. 1985 Oct 24-30;317(6039):745-8
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(120)
Other
accession IDs
MGD-MRK-10829, MGD-MRK-10887, MGI:2144140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory