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Hoxb5
Gene Detail
 Symbol
Name
ID
Hoxb5
homeobox B5
MGI:96186
Synonyms Hox-2.1
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:96302595-96306120 bp, + strand
From VEGA annotation of GRCm38

  3526 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb5

Human
homologs
Human Homolog HOXB5, homeobox B5
NCBI Gene ID 3215
neXtProt AC  NX_P09067
Human Synonyms  HHO.C10, HOX2, Hox2.1, HOX2A, HU-1
Human Chr (Location)  17q21.3; chr17:48591257-48593741 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile but exhibit a rostral shift of the shoulder girdle resulting in altered position of the forelimbs, and show variable anteriorizing homeotic transformations of cervicothoracic vertrebrae C6 through T1.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system development, ...
Component nucleus
Function DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (355)    Tissues (225)    Images (50)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 51
RNA in situ 181
Northern blot 16
Western blot 4
RT-PCR 78
RNase protection 25
cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(17) cDNA(37) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001987 (Evidence)
Ensembl Gene ModelENSMUSG00000038700 (Evidence)
Entrez Gene15413 (Evidence)
UniGene207
DFCITC1582898, TC1607754
DoTSDT.490141, DT.91311209
Consensus CDS ProjectCCDS25296.1
International Mouse Knockout Project StatusHoxb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001987 VEGA Gene Model | MGI Sequence Detail 3526 C57BL/6J ±  kb
transcript OTTMUST00000003992 VEGA | MGI Sequence Detail 2812 Not Applicable 
polypeptide OTTMUSP00000001930 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008702 homeobox protein Hox-B5
References (Earliest) J:8076 Jackson IJ, et al., A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature. 1985 Oct 24-30;317(6039):745-8
(Latest) J:203059 Xu B, et al., Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43
All references(118)
Other
accession IDs
MGD-MRK-10829, MGD-MRK-10887, MGI:2144140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory