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Hoxa9 Gene Detail
Summary
  • Symbol
    Hoxa9
  • Name
    homeobox A9
  • Synonyms
    D6a9, Hox-1.7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96180
    NCBI Gene: 15405
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA9
Location & Maps
more
  • Sequence Map
    Chr6:52223100-52231089 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HOXA9, homeobox A9
  • Vertebrate Orthologs
    13
  • Human Ortholog
    HOXA9, homeobox A9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABD-B, HOX1, HOX1.7, HOX1G
  • Links
    NCBI Gene ID: 3205
    neXtProt AC: NX_P31269

  • Chr Location
    7p15.2; chr7:27162438-27165530 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    33 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    1 involving Hoxa9
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit homeotic transformations affecting lumbar vertebrae, reduced spleen and thymus weights, and defects in myeloid, erythroid, and lymphoid hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018873 VEGA Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
transcript OTTMUST00000045395 VEGA | MGI Sequence Detail 3226 Not Applicable  
polypeptide OTTMUSP00000020422 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 57
    Genomic 16
    cDNA 27
    Primer pair 13
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10823, MGD-MRK-10881
References
more
  • Summaries
    All 117
    Developmental Gene Expression 60
    Gene Ontology 12
    Phenotypes 36
  • Earliest
    J:8939 Rubin MR, et al., Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression [published erratum appears in Mol Cell Biol 1988 Dec;8(12):5593]. Mol Cell Biol. 1987 Oct;7(10):3836-41
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory