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Hoxa9
Gene Detail
Symbol

Name
ID
Member of
Hoxa9
homeobox A9
MGI:96180
Hoxa cluster
Synonyms
D6a9, Hox-1.7
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:52223100-52231089 bp, - strand
From VEGA annotation of GRCm38

  7990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7766  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog

HCOP human homology predictions: HOXA9
Protein SuperFamily: homeobox protein, Hox9 type
Gene Tree: Hoxa9

Human
homologs
HOXA9, homeobox A9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3205
neXtProt AC: NX_P31269

Human Synonyms: ABD-B, HOX1, HOX1.7, HOX1G

Human Chr (Location): 7p15.2; chr7:27162438-27165530 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Hoxa9 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit homeotic transformations affecting lumbar vertebrae, reduced spleen and thymus weights, and defects in myeloid, erythroid, and lymphoid hematopoiesis.
 
Interactions
Hoxa9 interacts with 257 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process anterior/posterior pattern specification, definitive hemopoiesis, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (464)    Tissues (242)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 316
Northern blot 33
RT-PCR 112
RNase protection 3
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXA9 ZFIN hoxa9a, hoxa9b    NEW 
Molecular
reagents
All nucleic(57) Genomic(16) cDNA(27) Primer pair(13) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000018873 (Evidence)
Ensembl Gene Model ENSMUSG00000038227 (Evidence)
Entrez Gene 15405 (Evidence)
UniGene 4694
DFCI TC1585797, TC1594664
DoTS DT.486547
NIA Mouse Gene Index U027310
PDB 1PUF
Consensus CDS Project CCDS20146.1
International Mouse Phenotyping Consortium Status Hoxa9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018873 VEGA Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
transcript OTTMUST00000045395 VEGA | MGI Sequence Detail 3226 Not Applicable 
polypeptide OTTMUSP00000020422 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR017112 Homeobox protein Hox9
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
InterPro IPR006711 Hox9, N-terminal activation domain
Protein Ontology PR:000008696 homeobox protein Hox-A9
References
(Earliest) J:8939 Rubin MR, et al., Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression [published erratum appears in Mol Cell Biol 1988 Dec;8(12):5593]. Mol Cell Biol. 1987 Oct;7(10):3836-41
(Latest) J:221396 Sheikh BN, et al., MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5437-42
All references(114)
Other
accession IDs
MGD-MRK-10823, MGD-MRK-10881

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory