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Hoxa9
Gene Detail
Symbol

Name
ID
Member of
Hoxa9
homeobox A9
MGI:96180
Hoxa cluster
Synonyms
D6a9, Hox-1.7
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr6:52223100-52231089 bp, - strand
From VEGA annotation of GRCm38

  7990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7766  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog

Protein SuperFamily: homeobox protein, Hox9 type
Gene Tree: Hoxa9

Human
homologs
Human Homolog HOXA9, homeobox A9
NCBI Gene ID 3205
neXtProt AC  NX_P31269
Human Synonyms  ABD-B, HOX1, HOX1.7, HOX1G
Human Chr (Location)  7p15.2; chr7:27162438-27165530 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit homeotic transformations affecting lumbar vertebrae, reduced spleen and thymus weights, and defects in myeloid, erythroid, and lymphoid hematopoiesis.
 
Interactions
Hoxa9 interacts with 257 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process anterior/posterior pattern specification, definitive hemopoiesis, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (464)    Tissues (242)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 316
Northern blot 33
RT-PCR 112
RNase protection 3
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(16) cDNA(27) Primer pair(13) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018873 (Evidence)
Ensembl Gene ModelENSMUSG00000038227 (Evidence)
Entrez Gene15405 (Evidence)
UniGene4694
DFCITC1585797, TC1594664
DoTSDT.486547
NIA Mouse Gene IndexU027310
PDB1PUF
Consensus CDS ProjectCCDS20146.1
International Mouse Knockout Project StatusHoxa9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018873 VEGA Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
transcript OTTMUST00000045395 VEGA | MGI Sequence Detail 3226 Not Applicable 
polypeptide OTTMUSP00000020422 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017112 Homeobox protein Hox9
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
InterPro IPR006711 Hox9, N-terminal activation domain
Protein Ontology PR:000008696 homeobox protein Hox-A9
References
(Earliest) J:8939 Rubin MR, et al., Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression [published erratum appears in Mol Cell Biol 1988 Dec;8(12):5593]. Mol Cell Biol. 1987 Oct;7(10):3836-41
(Latest) J:212177 Collins C, et al., C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9899-904
All references(109)
Other
accession IDs
MGD-MRK-10823, MGD-MRK-10881

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory