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Hoxa9 Gene Detail
Summary
  • Symbol
    Hoxa9
  • Name
    homeobox A9
  • Synonyms
    D6a9, Hox-1.7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96180
    NCBI Gene: 15405
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:52223100-52231089 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HOXA9, homeobox A9
  • Vertebrate Orthologs
    13
  • Human Ortholog
    HOXA9, homeobox A9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABD-B, HOX1, HOX1.7, HOX1G
  • Links
    NCBI Gene ID: 3205
    neXtProt AC: NX_P31269
    UniProt: P31269

  • Chr Location
    7p15.2; chr7:27162438-27165530 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    33 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations affecting lumbar vertebrae, reduced spleen and thymus weights, and defects in myeloid, erythroid, and lymphoid hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018873 VEGA Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
    transcript OTTMUST00000045395 VEGA | MGI Sequence Detail 3226 Not Applicable  
    polypeptide OTTMUSP00000020422 VEGA | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      24 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 16
      cDNA 27
      Primer pair 14
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10823, MGD-MRK-10881
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 68
      Gene Ontology 15
      Phenotypes 37
    • Earliest
      J:8939 Rubin MR, et al., Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression [published erratum appears in Mol Cell Biol 1988 Dec;8(12):5593]. Mol Cell Biol. 1987 Oct;7(10):3836-41
    • Latest
      J:248920 Siriboonpiputtana T, et al., Transcriptional memory of cells of origin overrides beta-catenin requirement of MLL cancer stem cells. EMBO J. 2017 Nov 2;36(21):3139-3155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory