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Hoxa5
Gene Detail
 Symbol
Name
ID
Member of
Hoxa5
homeobox A5
MGI:96177
Hoxa cluster
Synonyms Hox-1.3
Feature Type protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:52201754-52204587 bp, - strand
From VEGA annotation of GRCm38

  2834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40726  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxa5

Human
homologs
Human Homolog HOXA5, homeobox A5
NCBI Gene ID 3202
neXtProt AC  NX_P20719
Human Synonyms  HOX1, HOX1.3, HOX1C
Human Chr (Location)  7p15.2; chr7:27141052-27143668 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show axial skeletal defects, tracheal and lung dysmorphogenesis, dyspnea, reduced surfactant production and partial neonatal lethality. Survivors exhibit stunted growth, delayed ear elevation and eyelid opening, altered thyroid development and digestive secretion, and emphysema.
 
Interactions
Hoxa5 interacts with 239 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process anterior/posterior pattern specification, bronchiole development, ...
Component nucleus
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (439)    Tissues (220)    Images (47)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 293
Northern blot 55
Western blot 14
RT-PCR 66
Nuclease S1 11
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(20) cDNA(26) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018868 (Evidence)
Ensembl Gene ModelENSMUSG00000038253 (Evidence)
Entrez Gene15402 (Evidence)
UniGene173
DFCITC1582538
DoTSDT.40186269
NIA Mouse Gene IndexU027307
Consensus CDS ProjectCCDS20143.1
International Mouse Knockout Project StatusHoxa5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018868 VEGA Gene Model | MGI Sequence Detail 2834 C57BL/6J ±  kb
transcript OTTMUST00000045387 VEGA | MGI Sequence Detail 1877 Not Applicable 
polypeptide OTTMUSP00000020420 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008693 homeobox protein Hox-A5
References (Earliest) J:8127 Colberg-Poley AM, et al., Clustered homeo boxes are differentially expressed during murine development. Cell. 1985 Nov;43(1):39-45
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(128)
Other
accession IDs
MGD-MRK-10819, MGD-MRK-10878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory