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Hoxa5
Gene Detail
Symbol

Name
ID
Member of
Hoxa5
homeobox A5
MGI:96177
Hoxa cluster
Synonyms
Hox-1.3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:52201754-52204587 bp, - strand
From VEGA annotation of GRCm38

  2834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40726  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXA5
Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxa5

Human
homologs
HOXA5, homeobox A5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3202
neXtProt AC: NX_P20719

Human Synonyms: HOX1, HOX1.3, HOX1C

Human Chr (Location): 7p15.2; chr7:27141052-27143668 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Hoxa5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show skeletal defects, tracheal and lung dysmorphology, reduced surfactant production, emphysema, and partial neonatal lethality. Survivors show stunted growth, delayed ear elevation and eyelid opening, and altered thyroid development, digestive secretion, and ovarian biology.
 
Interactions
Hoxa5 interacts with 239 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process anterior/posterior pattern specification, bronchiole development, ...
Component nucleus
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (439)    Tissues (220)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 293
Northern blot 55
Western blot 14
RT-PCR 66
Nuclease S1 11
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hoxa5 ; ZFIN hoxa5a    NEW 
Molecular
reagents
All nucleic(53) Genomic(20) cDNA(26) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018868 (Evidence)
Ensembl Gene Model ENSMUSG00000038253 (Evidence)
Entrez Gene 15402 (Evidence)
UniGene 173
DFCI TC1582538
DoTS DT.40186269
NIA Mouse Gene Index U027307
Consensus CDS Project CCDS20143.1
International Mouse Phenotyping Consortium Status Hoxa5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018868 VEGA Gene Model | MGI Sequence Detail 2834 C57BL/6J ±  kb
transcript OTTMUST00000045387 VEGA | MGI Sequence Detail 1877 Not Applicable 
polypeptide OTTMUSP00000020420 VEGA | MGI Sequence Detail 270 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008693 homeobox protein Hox-A5
References
(Earliest) J:8127 Colberg-Poley AM, et al., Clustered homeo boxes are differentially expressed during murine development. Cell. 1985 Nov;43(1):39-45
(Latest) J:217678 Karamitros D, et al., Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015 Jan 1;142(1):70-81
All references(130)
Other
accession IDs
MGD-MRK-10819, MGD-MRK-10878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory