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Hoxa5 Gene Detail
Summary
  • Symbol
    Hoxa5
  • Name
    homeobox A5
  • Synonyms
    Hox-1.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96177
    NCBI Gene: 15402
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA5
Location & Maps
more
  • Sequence Map
    Chr6:52201754-52204587 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2834 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    HOXA5, homeobox A5
  • Vertebrate Orthologs
    14
  • Human Ortholog
    HOXA5, homeobox A5
    Orthology source: HomoloGene
  • Synonyms
    HOX1, HOX1.3, HOX1C
  • Links
    NCBI Gene ID: 3202
    neXtProt AC: NX_P20719

  • Chr Location
    7p15.2; chr7:27141052-27143668 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 4 alleles in 7 genetic backgrounds
    16 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Genomic Mutations
    1 involving Hoxa5
  • Incidental Mutations
Nullizygous mice show skeletal defects, tracheal and lung dysmorphology, reduced surfactant production, emphysema, and partial neonatal lethality. Survivors show stunted growth, delayed ear elevation and eyelid opening, and altered thyroid development, digestive secretion, and ovarian biology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018868 VEGA Gene Model | MGI Sequence Detail 2834 C57BL/6J ±  kb
transcript OTTMUST00000045387 VEGA | MGI Sequence Detail 1877 Not Applicable  
polypeptide OTTMUSP00000020420 VEGA | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 53
    Genomic 20
    cDNA 26
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10819, MGD-MRK-10878
References
more
  • Summaries
    All 132
    Developmental Gene Expression 75
    Gene Ontology 18
    Phenotypes 36
  • Earliest
    J:8127 Colberg-Poley AM, et al., Clustered homeo boxes are differentially expressed during murine development. Cell. 1985 Nov;43(1):39-45
  • Latest
    J:231980 Tomas-Roca L, et al., Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016 Mar;221(2):815-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory