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Hoxa3
Gene Detail
Symbol

Name
ID
Member of
Hoxa3
homeobox A3
MGI:96175
Hoxa cluster
Synonyms
Hox-1.5, Mo-10
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr6:52169062-52213336 bp, - strand
From VEGA annotation of GRCm38

  44275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40725  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXA3
Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxa3

Human
homologs
HOXA3, homeobox A3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3200
neXtProt AC: NX_O43365

Human Synonyms: HOX1, HOX1E

Human Chr (Location): 7p15.2; chr7:27106190-27152581 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Genomic Mutations involving Hoxa3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations are athymic, aparathyroid, and exhibit reduced thyroid and submaxillary glands, defects of the IXth nerve, and frequently, heart and artery abnormalities. Mutants die neonatally.
 
Human Diseases Modeled in Mice Using Hoxa3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hoxa3 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process anterior/posterior pattern specification, blood vessel remodeling, ...
Component nucleoplasm, nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (410)    Tissues (226)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 304
Northern blot 6
RT-PCR 100
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXA3 ; Xenbase hoxa3 ; ZFIN hoxa3a    NEW 
Molecular
reagents
All nucleic(41) Genomic(17) cDNA(19) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018880 (Evidence)
Ensembl Gene Model ENSMUSG00000079560 (Evidence)
Entrez Gene 15400 (Evidence)
UniGene 71533
DFCI TC1583052, TC1631840
Consensus CDS Project CCDS20140.1
International Mouse Phenotyping Consortium Status Hoxa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018880 VEGA Gene Model | MGI Sequence Detail 44275 C57BL/6J ±  kb
transcript OTTMUST00000065040 VEGA | MGI Sequence Detail 2591 Not Applicable 
polypeptide OTTMUSP00000032362 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025281 Domain of unknown function DUF4074
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008691 homeobox protein Hox-A3
References
(Earliest) J:7605 McGinnis W, et al., Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell. 1984 Oct;38(3):675-80
(Latest) J:217678 Karamitros D, et al., Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015 Jan 1;142(1):70-81
All references(150)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10821, MGD-MRK-10876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory