Hoxa3
Gene Detail

Symbol Name ID

Hoxa3 homeobox A3 MGI:96175

Synonyms

Hox-1.5, Mo-10

Feature Type

protein coding gene

Genetic Map

Chromosome 6

25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr6:52168510-52213336 bp, - strand From VEGA annotation of GRCm38   44827 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxa3

Human homologs

Human Homolog		HOXA3, homeobox A3
NCBI Gene ID		3200
neXtProt AC		NX_O43365
Human Synonyms		HOX1, HOX1E
Human Chr (Location)		7p15.2; chr7:27145809-27166639 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Homozygotes for targeted null mutations are athymic, aparathyroid, and exhibit reduced thyroid and submaxillary glands, defects of the IXth nerve, and frequently, heart and artery abnormalities. Mutants die neonatally.

 
Human Diseases Modeled Using Mouse Hoxa3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	anterior/posterior pattern specification, blood vessel remodeling, ...
Component	nucleus
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (73 records)
Data Summary: Results (408)    Tissues (217)    Images (75)
Theiler Stages: 10, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	304
Northern blot	6
RT-PCR	98

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(17) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000018880 (Evidence)
Ensembl Gene Model	ENSMUSG00000079560 (Evidence)
Entrez Gene	15400 (Evidence)
DFCI	TC1583052, TC1631840
Consensus CDS Project	CCDS20140.1
International Mouse Knockout Project Status	Hoxa3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018880	VEGA Gene Model | MGI Sequence Detail	44827	C57BL/6J
transcript	OTTMUST00000065040	VEGA | MGI Sequence Detail	3095	Not Applicable
polypeptide	OTTMUSP00000032362	VEGA | MGI Sequence Detail	443	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025281	Domain of unknown function DUF4074
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008691	homeobox protein Hox-A3

References

(Earliest) J:7605 McGinnis W, et al., Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell. 1984 Oct;38(3):675-80
(Latest) J:192045 Suzuki K, et al., Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia. PLoS One. 2012;7(9):e43453
All references(141)

Other accession IDs

MGD-MRK-10821, MGD-MRK-10876