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Hoxa3
Gene Detail
 Symbol
Name
ID
Member of
Hoxa3
homeobox A3
MGI:96175
Hoxa cluster
Synonyms Hox-1.5, Mo-10
Feature Type protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr6:52163359-52213339 bp, - strand
From VEGA annotation of GRCm38

  49981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40725  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxa3

Human
homologs
Human Homolog HOXA3, homeobox A3
NCBI Gene ID 3200
neXtProt AC  NX_O43365
Human Synonyms  HOX1, HOX1E
Human Chr (Location)  7p15.2; chr7:27106184-27140186 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(4) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations are athymic, aparathyroid, and exhibit reduced thyroid and submaxillary glands, defects of the IXth nerve, and frequently, heart and artery abnormalities. Mutants die neonatally.
 
Human Diseases Modeled Using Mouse Hoxa3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hoxa3 interacts with 281 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process anterior/posterior pattern specification, blood vessel remodeling, ...
Component nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (410)    Tissues (218)    Images (76)
Theiler Stages: 10, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 304
Northern blot 6
RT-PCR 100
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(17) cDNA(19) Primer pair(4) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000018880 (Evidence)
Ensembl Gene ModelENSMUSG00000079560 (Evidence)
Entrez Gene15400 (Evidence)
UniGene71533
DFCITC1583052, TC1631840
Consensus CDS ProjectCCDS20140.1
International Mouse Knockout Project StatusHoxa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018880 VEGA Gene Model | MGI Sequence Detail 49981 C57BL/6J ±  kb
transcript OTTMUST00000065040 VEGA | MGI Sequence Detail 3095 Not Applicable 
polypeptide OTTMUSP00000032362 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025281 Domain of unknown function DUF4074
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008691 homeobox protein Hox-A3
References (Earliest) J:7605 McGinnis W, et al., Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell. 1984 Oct;38(3):675-80
(Latest) J:208432 Schwarz D, et al., Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77
All references(147)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10821, MGD-MRK-10876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory