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Hoxa3 Gene Detail
Summary
  • Symbol
    Hoxa3
  • Name
    homeobox A3
  • Synonyms
    Hox-1.5, Mo-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96175
    NCBI Gene: 15400
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA3
Location & Maps
more
  • Sequence Map
    Chr6:52169062-52213336 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44275 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    HOXA3, homeobox A3
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HOXA3, homeobox A3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX1, HOX1E
  • Links
    NCBI Gene ID: 3200
    neXtProt AC: NX_O43365

  • Chr Location
    7p15.2; chr7:27106190-27152581 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hoxa3 mouse models

Human Disease Mouse Models
       DiGeorge Syndrome; DGS   OMIM: 188400 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 7 alleles in 7 genetic backgrounds
    46 phenotypes from multigenic genotypes
    1 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Targeted
    14
  • Genomic Mutations
    1 involving Hoxa3
  • Incidental Mutations
Homozygotes for targeted null mutations are athymic, aparathyroid, and exhibit reduced thyroid and submaxillary glands, defects of the IXth nerve, and frequently, heart and artery abnormalities. Mutants die neonatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018880 VEGA Gene Model | MGI Sequence Detail 44275 C57BL/6J ±  kb
transcript OTTMUST00000065040 VEGA | MGI Sequence Detail 2591 Not Applicable  
polypeptide OTTMUSP00000032362 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    131 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 17
    cDNA 19
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10821, MGD-MRK-10876
References
more
  • Summaries
    All 153
    Developmental Gene Expression 82
    Diseases 1
    Gene Ontology 12
    Phenotypes 46
  • Earliest
    J:7605 McGinnis W, et al., Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell. 1984 Oct;38(3):675-80
  • Latest
    J:234117 Chojnowski JL, et al., Temporal and spatial requirements for Hoxa3 in mouse embryonic development. Dev Biol. 2016 Jul 1;415(1):33-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory