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Hoxa13
Gene Detail
Symbol

Name
ID
Member of
Hoxa13
homeobox A13
MGI:96173
Hoxa cluster
Synonyms
Hox-1.10
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr6:52257694-52260803 bp, - strand
From VEGA annotation of GRCm38

  3110 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73882  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXA13
Gene Tree: Hoxa13

Human
homologs
HOXA13, homeobox A13
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3209
neXtProt AC: NX_P31271

Human Synonyms: HOX1, HOX1J

Human Chr (Location): 7p15.2; chr7:27193419-27200266 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HOXA13

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(1) Targeted(7)
Genomic Mutations involving Hoxa13 (1)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a targeted null mutation exhibit agenesis of both the urinary bladder and the caudal portion of the Mullerian ducts, premature stenosis of the umbilical arteries, loss of the most anterior digit of all feet, and death around mid-gestation.
 
Human Diseases Modeled in Mice Using Hoxa13 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Hoxa13 interacts with 183 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process anatomical structure morphogenesis, artery morphogenesis, ...
Component intermediate filament cytoskeleton, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (78 records)
Data Summary: Results (481)    Tissues (243)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 318
In situ reporter (knock in) 52
Western blot 10
RT-PCR 100
RNase protection 1
cDNA source data(9)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA HOXA13 ZFIN hoxa13a, hoxa13b    NEW 
Molecular
reagents
All nucleic(29) Genomic(10) cDNA(9) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026296 (Evidence)
Ensembl Gene Model ENSMUSG00000038203 (Evidence)
Entrez Gene 15398 (Evidence)
UniGene 377086
DFCI TC1593618, TC1596727
DoTS DT.110476099, DT.91567453
PDB 2LD5
International Mouse Phenotyping Consortium Status Hoxa13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026296 VEGA Gene Model | MGI Sequence Detail 3110 C57BL/6J ±  kb
transcript OTTMUST00000065048 VEGA | MGI Sequence Detail 2395 Not Applicable 
polypeptide OTTMUSP00000062790 VEGA | MGI Sequence Detail 203 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR022067 Homeobox protein Hox1A3 N-terminal
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008689 homeobox protein Hox-A13
References
(Earliest) J:64253 Hummel KP, et al., Hd - hypodactyly. Mouse News Lett. 1966;34:31
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(131)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-10679, MGD-MRK-10816, MGD-MRK-10874, MGI:96061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory