Hoxa13
Gene Detail

Symbol Name ID

Hoxa13 homeobox A13 MGI:96173

Synonyms

Hox-1.10

Feature Type

protein coding gene

Genetic Map

Chromosome 6

25.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr6:52257694-52260803 bp, - strand From VEGA annotation of GRCm38   3110 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:73882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 3 chicken; 1 zebrafish

Gene Tree: Hoxa13

Human homologs

Human Homolog		HOXA13, homeobox A13
NCBI Gene ID		3209
neXtProt AC		NX_P31271
Human Synonyms		HOX1, HOX1J
Human Chr (Location)		7p15.2; chr7:27236499-27239725 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HOXA13

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Homozygotes for a targeted null mutation exhibit agenesis of both the urinary bladder and the caudal portion of the Mullerian ducts, premature stenosis of the umbilical arteries, loss of the most anterior digit of all feet, and death around mid-gestation.

 
Human Diseases Modeled Using Mouse Hoxa13 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	anatomical structure morphogenesis, artery morphogenesis, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (372)    Tissues (177)    Images (100)
Theiler Stages: 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	237
In situ reporter (knock in)	24
Western blot	10
RT-PCR	100
RNase protection	1

cDNA source data(9)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(10) cDNA(9) Primer pair(7) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026296 (Evidence)
Ensembl Gene Model	ENSMUSG00000038203 (Evidence)
Entrez Gene	15398 (Evidence)
UniGene	377086
DFCI	TC1593618, TC1596727
DoTS	DT.110476099, DT.91567453
PDB	2LD5
International Mouse Knockout Project Status	Hoxa13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026296	VEGA Gene Model | MGI Sequence Detail	3110	C57BL/6J
transcript	OTTMUST00000065048	VEGA | MGI Sequence Detail	2395	Not Applicable
polypeptide	OTTMUSP00000062790	VEGA | MGI Sequence Detail	203	Not Applicable

All sequences(33) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR022067	Homeobox protein Hox1A3 N-terminal
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000008689	homeobox protein Hox-A13

References

(Earliest) J:64253 Hummel KP, et al., Hd - hypodactyly. Mouse News Lett. 1966;34:31
(Latest) J:192010 Sheth R, et al., Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism. Science. 2012 Dec 14;338(6113):1476-80
All references(120)

Other accession IDs

MGD-MRK-10679, MGD-MRK-10816, MGD-MRK-10874, MGI:96061