Phenotypes Associated with This Genotype

Genotype
MGI:3587031

• Allelic Composition: Hoxa13^Hd/Hoxa13⁺
• Genetic Background: B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ampullary gland morphology ( J:54823 )

♂ • decrease in the number of duct tips in the ampullary gland

abnormal prostate gland anterior lobe morphology ( J:54823 )

♂ • 29% have one lobe of the coagulating gland duct that has a single main duct

small prostate gland dorsolateral lobe ( J:54823 )

♂ • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate

decreased prostate gland duct number ( J:54823 )

♂ • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate

small prostate gland ventral lobe ( J:54823 )

♂ • 43% have a smaller ventral prostate

abnormal seminal vesicle morphology ( J:54823 )

♂ • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches

abnormal branching involved in seminal vesicle morphogenesis ( J:54823 )

♂ • little secondary and tertiary branching is observed

small seminal vesicle ( J:54823 )

♂ • 86% have seminal vesicles that are two thirds the size of wild-type

reproductive system

abnormal ampullary gland morphology ( J:54823 )

♂ • decrease in the number of duct tips in the ampullary gland

abnormal prostate gland anterior lobe morphology ( J:54823 )

♂ • 29% have one lobe of the coagulating gland duct that has a single main duct

small prostate gland dorsolateral lobe ( J:54823 )

♂ • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate

decreased prostate gland duct number ( J:54823 )

♂ • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate

small prostate gland ventral lobe ( J:54823 )

♂ • 43% have a smaller ventral prostate

abnormal seminal vesicle morphology ( J:54823 )

♂ • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches

abnormal branching involved in seminal vesicle morphogenesis ( J:54823 )

♂ • little secondary and tertiary branching is observed

small seminal vesicle ( J:54823 )

♂ • 86% have seminal vesicles that are two thirds the size of wild-type

abnormal uterine cervix morphology ( J:58731 )

♀ • exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hand-foot-genital syndrome		DOID:0060739	OMIM:140000	J:54823