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Hoxa11 Gene Detail
Summary
  • Symbol
    Hoxa11
  • Name
    homeobox A11
  • Synonyms
    Hox-1.9, Hoxa-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:96172
    NCBI Gene: 15396
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:52242106-52245810 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3705 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HOXA11, homeobox A11
  • Vertebrate Orthologs
    14
  • Human Ortholog
    HOXA11, homeobox A11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX1, HOX1I, RUSAT1
  • Links
    NCBI Gene ID: 3207
    neXtProt AC: NX_P31270
    UniProt: P31270

  • Chr Location
    7p15.2; chr7:27181157-27185216 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4033
    1 human;1 mouse;3 rat;1 chimpanzee;1 cattle;1 dog;3 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HOXA11
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    70 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations affecting thoracic and sacral vertebrae, and forelimb defects. Mutants are sterile due to malformed vas deferens and cryptorchism in males, and defective uteri in females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018883 VEGA Gene Model | MGI Sequence Detail 3705 C57BL/6J ±  kb
    transcript OTTMUST00000045416 VEGA | MGI Sequence Detail 2287 Not Applicable  
    polypeptide OTTMUSP00000020426 VEGA | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      11 from dbSNP Build 142
    • RFLP
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 33
      Genomic 6
      cDNA 19
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10825, MGD-MRK-10873
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 83
      Gene Ontology 17
      Phenotypes 34
    • Earliest
      J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory