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Hoxa11
Gene Detail
 Symbol
Name
ID
Member of
Hoxa11
homeobox A11
MGI:96172
Hoxa cluster
Synonyms Hox-1.9, Hoxa-11
Feature Type protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:52242106-52245810 bp, - strand
From VEGA annotation of GRCm38

  3705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4033  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hoxa11

Human
homologs
Human Homolog HOXA11, homeobox A11
NCBI Gene ID 3207
neXtProt AC  NX_P31270
Human Synonyms  HOX1, HOX1I
Human Chr (Location)  7p15.2; chr7:27181157-27185216 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOXA11
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Homozygotes for targeted null mutations exhibit homeotic transformations affecting thoracic and sacral vertebrae, and forelimb defects. Mutants are sterile due to malformed vas deferens and cryptorchism in males, and defective uteri in females.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Hoxa11 interacts with 215 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process anterior/posterior pattern specification, branching involved in ureteric bud morphogenesis, ...
Component nucleus, protein complex, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (178)    Tissues (122)    Images (52)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 137
RT-PCR 31
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018883 (Evidence)
Ensembl Gene ModelENSMUSG00000038210 (Evidence)
Entrez Gene15396 (Evidence)
UniGene26954
DFCITC1585827
Consensus CDS ProjectCCDS20148.1
International Mouse Knockout Project StatusHoxa11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018883 VEGA Gene Model | MGI Sequence Detail 3705 C57BL/6J ±  kb
transcript OTTMUST00000045416 VEGA | MGI Sequence Detail 2287 Not Applicable 
polypeptide OTTMUSP00000020426 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008688 homeobox protein Hox-A11
References (Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:204375 Sheth R, et al., "Self-regulation," a new facet of Hox genes' function. Dev Dyn. 2014 Jan;243(1):182-91
All references(114)
Other
accession IDs
MGD-MRK-10825, MGD-MRK-10873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory