Hoxa11
Gene Detail

Symbol Name ID

Hoxa11 homeobox A11 MGI:96172

Synonyms

Hox-1.9, Hoxa-11

Feature Type

protein coding gene

Genetic Map

Chromosome 6

25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:52242108-52246214 bp, - strand From VEGA annotation of GRCm38   4107 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 chicken; 1 zebrafish

Gene Tree: Hoxa11

Human homologs

Human Homolog		HOXA11, homeobox A11
NCBI Gene ID		3207
neXtProt AC		NX_P31270
Human Synonyms		HOX1, HOX1I
Human Chr (Location)		7p15.2; chr7:27220776-27224835 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXA11

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations exhibit homeotic transformations affecting thoracic and sacral vertebrae, and forelimb defects. Mutants are sterile due to malformed vas deferens and cryptorchism in males, and defective uteri in females.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	anterior/posterior pattern specification, branching involved in ureteric bud morphogenesis, ...
Component	cytoplasm, nucleolus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (178)    Tissues (121)    Images (52)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	137
RT-PCR	31

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(6) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018883 (Evidence)
Ensembl Gene Model	ENSMUSG00000038210 (Evidence)
Entrez Gene	15396 (Evidence)
UniGene	26954
DFCI	TC1585827
Consensus CDS Project	CCDS20148.1
International Mouse Knockout Project Status	Hoxa11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018883	VEGA Gene Model | MGI Sequence Detail	4107	C57BL/6J
transcript	OTTMUST00000045416	VEGA | MGI Sequence Detail	2689	Not Applicable
polypeptide	OTTMUSP00000020426	VEGA | MGI Sequence Detail	313	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021918	Domain of unknown function DUF3528, homeobox protein, eukaryotic
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008688	homeobox protein Hox-A11

References

(Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:191689 Gross S, et al., Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One. 2012;7(8):e43553
All references(107)

Other accession IDs

MGD-MRK-10825, MGD-MRK-10873