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Hoxa1
Gene Detail
 Symbol
Name
ID
Hoxa1
homeobox A1
MGI:96170
Synonyms early retinoic acid, ERA1, Hox-1.6
Feature Type protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:52155590-52158317 bp, - strand
From VEGA annotation of GRCm38

  2728 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4032  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxa1

Human
homologs
Human Homolog HOXA1, homeobox A1
NCBI Gene ID 3198
neXtProt AC  NX_P49639
Human Synonyms  BSAS, HOX1, HOX1F
Human Chr (Location)  7p15.3; chr7:27092993-27096006 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOXA1
Alleles
and
phenotypes
All alleles(18) : Gene trapped(3) Targeted(15)
 
Homozygotes for targeted null mutations die perinatally and exhibit altered and missing rhombomeric structures associated with abnormalities of cranial nerves and ganglia, defects in the skull, and both outer and inner ears, and anoxia at birth.
 
Human Diseases Modeled Using Mouse Hoxa1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process abducens nerve formation, anatomical structure formation involved in morphogenesis, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (301)    Tissues (226)    Images (46)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 256
In situ reporter (knock in) 2
Northern blot 27
RT-PCR 8
Nuclease S1 8
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) Genomic(11) cDNA(28) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018885 (Evidence)
Ensembl Gene ModelENSMUSG00000029844 (Evidence)
Entrez Gene15394 (Evidence)
UniGene197
DFCITC1588487
DoTSDT.40167516
NIA Mouse Gene IndexU027300
Consensus CDS ProjectCCDS20138.1
International Mouse Knockout Project StatusHoxa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018885 VEGA Gene Model | MGI Sequence Detail 2728 C57BL/6J ±  kb
transcript OTTMUST00000045418 VEGA | MGI Sequence Detail 2251 Not Applicable 
polypeptide OTTMUSP00000020428 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(5)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008686 homeobox protein Hox-A1
References (Earliest) J:8427 Duboule D, et al., A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus. EMBO J. 1986 Aug;5(8):1973-80
(Latest) J:203823 Billings SE, et al., The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89
All references(131)
Other
accession IDs
MGD-MRK-10822, MGD-MRK-10871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory