Hoxa1
Gene Detail

Symbol Name ID

Hoxa1 homeobox A1 MGI:96170

Synonyms

early retinoic acid, ERA1, Hox-1.6

Feature Type

protein coding gene

Genetic Map

Chromosome 6

25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:52155367-52158317 bp, - strand From VEGA annotation of GRCm38   2951 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4032  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxa1

Human homologs

Human Homolog		HOXA1, homeobox A1
NCBI Gene ID		3198
neXtProt AC		NX_P49639
Human Synonyms		BSAS, HOX1, HOX1F
Human Chr (Location)		7p15.3; chr7:27132612-27135625 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXA1

Alleles and phenotypes

All alleles(17) : Targeted(14) Gene trapped(3)
 

Homozygotes for targeted null mutations die perinatally and exhibit altered and missing rhombomeric structures associated with abnormalities of cranial nerves and ganglia, defects in the skull, and both outer and inner ears, and anoxia at birth.

 
Human Diseases Modeled Using Mouse Hoxa1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	abducens nerve formation, anatomical structure formation involved in morphogenesis, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (297)    Tissues (226)    Images (43)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	254
In situ reporter (knock in)	2
Northern blot	27
RT-PCR	6
Nuclease S1	8

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(11) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018885 (Evidence)
Ensembl Gene Model	ENSMUSG00000029844 (Evidence)
Entrez Gene	15394 (Evidence)
UniGene	197
DFCI	TC1588487
DoTS	DT.40167516
NIA Mouse Gene Index	U027300
Consensus CDS Project	CCDS20138.1
International Mouse Knockout Project Status	Hoxa1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018885	VEGA Gene Model | MGI Sequence Detail	2951	C57BL/6J
transcript	OTTMUST00000045418	VEGA | MGI Sequence Detail	2474	Not Applicable
polypeptide	OTTMUSP00000020428	VEGA | MGI Sequence Detail	336	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008686	homeobox protein Hox-A1

References

(Earliest) J:8427 Duboule D, et al., A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus. EMBO J. 1986 Aug;5(8):1973-80
(Latest) J:190682 Lambert B, et al., Protein interactions of the transcription factor Hoxa1. BMC Dev Biol. 2012;12:29
All references(128)

Other accession IDs

MGD-MRK-10822, MGD-MRK-10871