About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hoxa1
homeobox A1
MGI:96170
45 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Hoxa1tm1Ipc/\Hoxa1tm1Ipc
\Hoxb1tm1Ipc/\Hoxb1tm1Ipc
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal neural crest cell delamination J:71033
abnormal neural crest cell migration J:71033
normal embryo phenotype J:71033
normal muscle phenotype J:124278
\Hoxa1tm1Mrc/\Hoxa1tm2Mrc
\Hoxa2tm1Mrc/\Hoxa2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal basioccipital bone morphology J:58093
abnormal cranium morphology J:58093
absent stapes J:58093
neonatal lethality, complete penetrance J:58093
respiratory failure J:58093
small ears J:58093
small middle ear ossicles J:58093
\Hoxa1tm2Mrc/\Hoxa1+
\Hoxa2tm1Mrc/\Hoxa2+
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:58093
\Hoxa1tm2Mrc/\Hoxa1+
\Hoxa2tm1Mrc/\Hoxa2tm1Mrc
involves: 129S1/Sv * 129X1/SvJ 		abnormal suckling behavior J:58093
cleft secondary palate J:58093
neonatal lethality, complete penetrance J:58093
\Hoxa1tm2Mrc/\Hoxa1tm2Mrc
\Hoxa2tm1Mrc/\Hoxa2tm1Mrc
involves: 129S1/Sv * 129X1/SvJ 		abnormal hindbrain morphology J:58093
abnormal middle ear ossicle morphology J:58093
absent outer ear J:58093
neonatal lethality, complete penetrance J:58093
small middle ear ossicles J:58093
\Hoxa1tm3.1Mrc/\Hoxa1tm3.1Mrc
\Hoxb1tm3Mrc/\Hoxb1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal neural crest cell migration J:41540
abnormal neuron differentiation J:41540
abnormal pharyngeal pouch morphology J:41540
abnormal rhombomere morphology J:41540
absent parathyroid glands J:41540
absent second pharyngeal arch J:41540
small thymus J:41540
\Hoxa1tm3.1Mrc/\Hoxa1tm3.1Mrc
\Hoxb1tm3Mrc/\Hoxb1tm3Mrc
involves: 129S1/Sv * 129X1/SvJ 		abnormal digastric posterior belly morphology J:41540
abnormal neural crest cell migration J:41540
abnormal neuron differentiation J:41540
abnormal rhombomere morphology J:41540
abnormal stylohyoid muscle morphology J:41540
abnormal third pharyngeal pouch morphology J:41540
absent facial muscle J:41540
absent levator labii superioris muscle J:41540
absent orbicularis oculi muscle J:41540
absent parathyroid glands J:41540
absent rhombomere 4 J:41540
absent rhombomere 5 J:41540
absent second pharyngeal arch J:41540
absent second pharyngeal pouch J:41540
absent stapes J:41540
absent zygomaticus muscle J:41540
athymia J:41540
increased hindbrain apoptosis J:41540
pulmonary hypoplasia J:41540
small incus J:41540
small malleus J:41540
\Hoxa1tm3.1Mrc/\Hoxa1tm4(Hoxb1)Mrc
\Hoxb1tm5Mrc/\Hoxb1tm8(Hoxa1)Mrc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal blinking J:119279
facial paralysis J:119279
\Hoxa1tm4(Hoxb1)Mrc/\Hoxa1tm4(Hoxb1)Mrc
\Hoxb1tm5Mrc/\Hoxb1tm8(Hoxa1)Mrc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal facial nerve morphology J:119279
abnormal reflex J:119279
\Hoxa1tm4(Hoxb1)Mrc/\Hoxa1tm4(Hoxb1)Mrc
\Hoxb1tm8(Hoxa1)Mrc/\Hoxb1tm8(Hoxa1)Mrc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		no abnormal phenotype detected J:119279
\Hoxa1tm5Mrc/\Hoxa1+
\Hoxb1tm5Mrc/\Hoxb1tm5Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal facial nerve morphology J:119279
abnormal reflex J:119279
paralysis J:119279
small facial motor nucleus J:119279
\Hoxa1tm5Mrc/\Hoxa1tm5Mrc
\Hoxb1tm5Mrc/\Hoxb1tm5Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal nervous system phenotype J:119279
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory