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Hmgn1 Gene Detail
Summary
  • Symbol
    Hmgn1
  • Name
    high mobility group nucleosomal binding domain 1
  • Synonyms
    Hmg14, HMG-14
  • Feature Type
    protein coding gene
  • IDs
    MGI:96120
    NCBI Gene: 15312
  • Gene Overview
    MyGene.info: HMGN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:96120618-96127729 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7112 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.83 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    HMGN1, high mobility group nucleosome binding domain 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HMGN1, high mobility group nucleosome binding domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMG14
  • Links
    NCBI Gene ID: 3150
    neXtProt AC: NX_P05114
    UniProt: P05114

  • Chr Location
    21q22.2; chr21:39342315-39349121 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display partial embryonic lethality, increased cellular sensitivity to ultraviolet- and gamma-irradiation, increased tumor incidence and metastatic potential, increased incidence of ionizing radiation-induced tumors, and abnormal cell cycle checkpoint function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019978 VEGA Gene Model | MGI Sequence Detail 7112 C57BL/6J ±  kb
    transcript OTTMUST00000047610 VEGA | MGI Sequence Detail 2174 Not Applicable  
    polypeptide OTTMUSP00000021569 VEGA | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      49 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR000079 High mobility group protein HMGN
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 11
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10756
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 8
      Phenotypes 43
    • Earliest
      J:10494 Pash J, et al., Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. Proc Natl Acad Sci U S A. 1990 May;87(10):3836-40
    • Latest
      J:253021 William CM, et al., Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome. J Neurosci. 2017 Oct 11;37(41):9880-9888

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory