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Hmgn1
Gene Detail
 Symbol
Name
ID
Hmgn1
high mobility group nucleosomal binding domain 1
MGI:96120
Synonyms Hmg14, HMG-14
Feature Type protein coding gene
Genetic Map
Chromosome 16
56.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:96120618-96127729 bp, - strand
From VEGA annotation of GRCm38

  7112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3643  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: nonhistone chromosomal protein HMG-17
Gene Tree: Hmgn1

Human
homologs
Human Homolog HMGN1, high mobility group nucleosome binding domain 1
NCBI Gene ID 3150
neXtProt AC  NX_P05114
Human Synonyms  HMG14
Human Chr (Location)  21q22.2; chr21:39342315-39349121 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(24) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display partial embryonic lethality, increased cellular sensitivity to ultraviolet- and gamma-irradiation, increased tumor incidence and metastatic potential, increased incidence of ionizing radiation-induced tumors, and abnormal cell cycle checkpoint function.
 
Interactions
Hmgn1 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin organization, post-embryonic camera-type eye morphogenesis, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (342)    Tissues (216)    Images (87)
Theiler Stages: 13, 15, 17, 18, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 52
RNA in situ 264
RT-PCR 26
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(11) Primer pair(3) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000019978 (Evidence)
Ensembl Gene ModelENSMUSG00000040681 (Evidence)
Entrez Gene15312 (Evidence)
DFCITC1573208
DoTSDT.102540405, DT.537311, DT.94231484, DT.94231496
NIA Mouse Gene IndexU037343, U074483, U146974, U165056
Consensus CDS ProjectCCDS28353.1
International Mouse Knockout Project StatusHmgn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019978 VEGA Gene Model | MGI Sequence Detail 7112 C57BL/6J ±  kb
transcript OTTMUST00000047610 VEGA | MGI Sequence Detail 2174 Not Applicable 
polypeptide OTTMUSP00000021569 VEGA | MGI Sequence Detail 96 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(49 from dbSNP Build 137)    SNPs within 2kb including multiple locations(51)
Protein-related
information
ResourceIDDescription
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
Protein Ontology PR:000008639 non-histone chromosomal protein HMG-14
References (Earliest) J:10494 Pash J, et al., Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. Proc Natl Acad Sci U S A. 1990 May;87(10):3836-40
(Latest) J:206974 Postnikov YV, et al., Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. Mol Cancer Res. 2014 Jan;12(1):82-90
All references(66)
Other
accession IDs
MGD-MRK-10756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory