Hmgn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmgn1
high mobility group nucleosomal binding domain 1
MGI:96120

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmgn1^em1(IMPC)Ics/Hmgn1^em1(IMPC)Ics C57BL/6N-Hmgn1^em1(IMPC)Ics/Ics	decreased circulating creatinine level	J:211773
	decreased food intake	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Hmgn1^tm1Mbus/Hmgn1⁺ either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)	increased cellular sensitivity to ultraviolet irradiation	J:100282
Hmgn1^tm1Mbus/Hmgn1⁺ involves: 129X1/SvJ	increased cellular sensitivity to gamma-irradiation	J:100773
Hmgn1^tm1Mbus/Hmgn1⁺ involves: 129X1/SvJ	increased mortality induced by gamma-irradiation	J:100773
Hmgn1^tm1Mbus/Hmgn1^tm1Mbus either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)	abnormal cell physiology	J:100282
	embryonic lethality during organogenesis, incomplete penetrance	J:100282
	increased cellular sensitivity to ultraviolet irradiation	J:100282
	increased sensitivity to skin irradiation	J:100282
Hmgn1^tm1Mbus/Hmgn1^tm1Mbus involves: 129X1/SvJ	abnormal cell cycle checkpoint function	J:100773
	decreased circulating corticosterone level	J:199604
	decreased prepulse inhibition	J:199604
	decreased startle reflex	J:199604
	decreased vertical activity	J:199604
	increased cellular sensitivity to gamma-irradiation	J:100773
	increased fibroblast proliferation	J:100773
	increased hemangioma incidence	J:100773
	increased incidence of tumors by ionizing radiation induction	J:100773
	increased malignant tumor incidence	J:100773
	increased metastatic potential	J:100773
	increased mortality induced by gamma-irradiation	J:100773
	increased pheochromocytoma incidence	J:100773
	increased tumor incidence	J:100773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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