About   Help   FAQ
Hmgb1 Gene Detail
Summary
  • Symbol
    Hmgb1
  • Name
    high mobility group box 1
  • Synonyms
    amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96113
    NCBI Gene: 15289
  • Gene Overview
    MyGene.info: HMGB1
Location & Maps
more
  • Sequence Map
    Chr5:149046702-149184489 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      137788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.18 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HMGB1, high mobility group box 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HMGB1, high mobility group box 1
    Orthology source: HGNC
  • Synonyms
    HMG1, HMG-1, HMG3, SBP-1
  • Links
    NCBI Gene ID: 3146
    neXtProt AC: NX_P09429

  • Chr Location
    13q12; chr13:30458740-30465944 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016672 VEGA Gene Model | MGI Sequence Detail 137788 C57BL/6J ±  kb
transcript OTTMUST00000040356 VEGA | MGI Sequence Detail 2838 Not Applicable  
polypeptide OTTMUSP00000018031 VEGA | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    512 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • Protein Ontology
    PR:000008630 high mobility group protein B1
Molecular
Reagents
less
  • All nucleic 51
    Genomic 4
    cDNA 38
    Primer pair 6
    Other 3

    Microarray probesets 25
Other
Accession IDs
less
MGD-MRK-10748
References
more
  • Summaries
    All 125
    Developmental Gene Expression 23
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:1523 Yotov WV, et al., Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 1992 Jul 11;20(13):3516
  • Latest
    J:229389 Vogel S, et al., Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest. 2015 Dec;125(12):4638-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory