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Hmgb1
Gene Detail
Symbol

Name
ID
Hmgb1
high mobility group box 1
MGI:96113
Synonyms
amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
89.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:149046702-149053513 bp, - strand
From VEGA annotation of GRCm38

  6812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135819  Vertebrate Homology Class
2 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HMGB1
Gene Tree: Hmgb1

Human
homologs
HMGB1, high mobility group box 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 3146
neXtProt AC: NX_P09429

Human Synonyms: HMG1, HMG3, SBP-1

Human Chr (Location): 13q12; chr13:30458740-30465944 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy.
 
Interactions
Hmgb1 interacts with 346 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chromatin remodeling, DNA geometric change, ...
Component cytoplasm, extracellular space, ...
Function bent DNA binding, calcium-dependent protein kinase regulator activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (205)    Tissues (100)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 161
Northern blot 1
RT-PCR 36
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hmgb1 ; ZFIN hmgb1a, hmgb1b    NEW 
Molecular
reagents
All nucleic(51) Genomic(4) cDNA(38) Primer pair(6) Other(3)
Microarray probesets(25)
Other database
links
VEGA Gene Model OTTMUSG00000016672 (Evidence)
Ensembl Gene Model ENSMUSG00000066551 (Evidence)
Entrez Gene 15289 (Evidence)
DoTS DT.101306237, DT.110574069, DT.110698011, DT.110698027, DT.110843874, DT.483763, DT.55132639, DT.55216196, DT.87073128, DT.91588894, DT.94209624
Consensus CDS Project CCDS19883.1
International Mouse Phenotyping Consortium Status Hmgb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016672 VEGA Gene Model | MGI Sequence Detail 6812 C57BL/6J ±  kb
transcript OTTMUST00000040356 VEGA | MGI Sequence Detail 2838 Not Applicable 
polypeptide OTTMUSP00000018031 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008630 high mobility group protein B1
References
(Earliest) J:1523 Yotov WV, et al., Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 1992 Jul 11;20(13):3516
(Latest) J:220563 Huebener P, et al., The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest. 2015 Feb;125(2):539-50
All references(117)
Other
accession IDs
MGD-MRK-10748

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory