About   Help   FAQ
Hmgb1
Gene Detail
 Symbol
Name
ID
Hmgb1
high mobility group box 1
MGI:96113
Synonyms amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
89.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:149046702-149053513 bp, - strand
From VEGA annotation of GRCm38

  6812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135819  Vertebrate Homology Class
2 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Gene Tree: Hmgb1

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy.
 
Interactions
Hmgb1 interacts with 346 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process DNA geometric change, eye development, ...
Component cytoplasm, extracellular space, ...
Function bent DNA binding, calcium-dependent protein kinase regulator activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (205)    Tissues (100)    Images (51)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 17, 18, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 161
Northern blot 1
RT-PCR 36
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(4) cDNA(38) Primer pair(6) Other(3)
Microarray probesets(25)
Other database
links
VEGA Gene ModelOTTMUSG00000016672 (Evidence)
Ensembl Gene ModelENSMUSG00000066551 (Evidence)
Entrez Gene15289 (Evidence)
DoTSDT.101306237, DT.110574069, DT.110698011, DT.110698027, DT.110843874, DT.483763, DT.55132639, DT.55216196, DT.87073128, DT.91588894, DT.94209624
Consensus CDS ProjectCCDS19883.1
International Mouse Knockout Project StatusHmgb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016672 VEGA Gene Model | MGI Sequence Detail 6812 C57BL/6J ±  kb
transcript OTTMUST00000040356 VEGA | MGI Sequence Detail 2838 Not Applicable 
polypeptide OTTMUSP00000018031 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(4)
Polymorphisms RFLP(2) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008630 high mobility group protein B1
References (Earliest) J:1523 Yotov WV, et al., Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 1992 Jul 11;20(13):3516
(Latest) J:211961 Jiang G, et al., HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells. J Leukoc Biol. 2014 Apr;95(4):599-607
All references(115)
Other
accession IDs
MGD-MRK-10748

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory