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Hmgb1 Gene Detail
Summary
  • Symbol
    Hmgb1
  • Name
    high mobility group box 1
  • Synonyms
    amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96113
    NCBI Gene: 15289
  • Gene Overview
    MyGene.info: HMGB1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:148983512-148989867 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96113
protein coding gene Chr5:148983512-149121299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030399
protein coding gene Chr5:154846976-154998209 (-)
A/J MGP_AJ_G0030372
protein coding gene Chr5:148250654-148389807 (-)
AKR/J MGP_AKRJ_G0030299
protein coding gene Chr5:152813556-152969998 (-)
BALB/cJ MGP_BALBcJ_G0030381
protein coding gene Chr5:149492398-149639735 (-)
C3H/HeJ MGP_C3HHeJ_G0030095
protein coding gene Chr5:153801958-153959423 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030836
protein coding gene Chr5:160538349-160699822 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028049
protein coding gene Chr5:142614575-142746981 (-)
CAST/EiJ MGP_CASTEiJ_G0029497
protein coding gene Chr5:153411365-153567600 (-)
CBA/J MGP_CBAJ_G0030073
protein coding gene Chr5:167232836-167423709 (-)
DBA/2J MGP_DBA2J_G0030217
protein coding gene Chr5:147902221-148046311 (-)
FVB/NJ MGP_FVBNJ_G0030171
protein coding gene Chr5:147146605-147297478 (-)
LP/J MGP_LPJ_G0030304
protein coding gene Chr5:155525921-155695908 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030207
protein coding gene Chr5:169410259-169577880 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030866
protein coding gene Chr5:152752612-152896648 (-)
PWK/PhJ MGP_PWKPhJ_G0029211
protein coding gene Chr5:147055106-147199686 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029047
protein coding gene Chr5:150046471-150199442 (-)
WSB/EiJ MGP_WSBEiJ_G0029574
protein coding gene Chr5:153561993-153712840 (-)



Homology
more
  • Human Ortholog
    HMGB1, high mobility group box 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGB1, high mobility group box 1
  • Synonyms
    HMG1, HMG-1, HMG3, SBP-1
  • Links
    NCBI Gene ID: 3146
    neXtProt AC: NX_P09429
    UniProt: P09429

  • Chr Location
    13q12.3; chr13:30457916-30617597 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 8 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15289 NCBI Gene Model | MGI Sequence Detail 6356 C57BL/6J ±  kb
    transcript NM_001313894 RefSeq | MGI Sequence Detail 3035 C57BL/6  
    polypeptide P63158 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 4
      cDNA 39
      Primer pair 7
      Other 3

      Microarray probesets 25
    Other
    Accession IDs
    less
    MGD-MRK-10748
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 31
      Gene Ontology 26
      Phenotypes 39
    • Earliest
      J:1523 Yotov WV, et al., Nucleotide sequence of a mouse cDNA encoding the nonhistone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 1992 Jul 11;20(13):3516
    • Latest
      J:309523 Yang H, et al., HMGB1 released from nociceptors mediates inflammation. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/16/2021
    MGI 6.17
    The Jackson Laboratory