Ptpn6
Gene Detail

Symbol Name ID

Ptpn6 protein tyrosine phosphatase, non-receptor type 6 MGI:96055

Synonyms

hcp, Hcph, Ptp1C, SHP-1, Spin

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr6:124720707-124738714 bp, - strand From VEGA annotation of GRCm38   18008 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56589  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 6/11 types
Gene Tree: Ptpn6

Human homologs

Human Homolog		PTPN6, protein tyrosine phosphatase, non-receptor type 6
NCBI Gene ID		5777
neXtProt AC		NX_P29350
Human Synonyms		HCP, HCPH, HPTP1C, PTP-1C, SHP1, SHP-1, SHP-1L, SH-PTP1
Human Chr (Location)		12p13; chr12:7055740-7070479 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(3) Spontaneous(4) Chemically induced(3)
 

Homozygous mutants are immunodeficient and autoimmune and exhibit neutrophilic skin lesions that disrupt hair follicles and give the motheaten appearance. Alleles vary in severity, with death occurring at 6-9 weeks postnatally due to severe pneumonitis.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	B cell receptor signaling pathway, cell differentiation, ...
Component	alpha-beta T cell receptor complex, cytoplasm, ...
Function	hydrolase activity, natural killer cell lectin-like receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (51)    Tissues (10)    Images (22)
Theiler Stages: 10, 18, 21, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	27
Northern blot	4
Western blot	9
RT-PCR	8

cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(3) cDNA(66) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000038210 (Evidence)
Ensembl Gene Model	ENSMUSG00000004266 (Evidence)
Entrez Gene	15170 (Evidence)
UniGene	271799
DFCI	TC1577727, TC1596434, TC1633761, TC1664043, TC1679288
DoTS	DT.493244, DT.91308995, DT.94207958
NIA Mouse Gene Index	U027845
EC	3.1.3.48
Consensus CDS Project	CCDS39628.1, CCDS51908.1
International Mouse Knockout Project Status	Ptpn6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000038210	VEGA Gene Model | MGI Sequence Detail	18008	C57BL/6J
transcript	OTTMUST00000098375	VEGA | MGI Sequence Detail	2308	Not Applicable
polypeptide	OTTMUSP00000055278	VEGA | MGI Sequence Detail	597	Not Applicable

All sequences(80) RefSeq(4) UniProt(8)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR012152	Protein-tyrosine phosphatase, non-receptor type-6, -11
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000013461	tyrosine-protein phosphatase non-receptor type 6

References

(Earliest) J:13520 Green MC, Cribriform degeneration, cri. Mouse News Lett. 1971;45:29
(Latest) J:195276 Abram CL, et al., Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 2013 Mar 21;38(3):489-501
All references(221)

Other accession IDs

MGD-MRK-10672, MGD-MRK-12181