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Ptpn6 Gene Detail
Summary
  • Symbol
    Ptpn6
  • Name
    protein tyrosine phosphatase, non-receptor type 6
  • Synonyms
    hcp, Hcph, Ptp1C, SHP-1, Spin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96055
    NCBI Gene: 15170
  • Gene Overview
    MyGene.info: PTPN6
Location & Maps
more
  • Sequence Map
    Chr6:124720707-124738714 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    PTPN6, protein tyrosine phosphatase, non-receptor type 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN6, protein tyrosine phosphatase, non-receptor type 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCP, HCPH, HPTP1C, PTP-1C, SHP1, SHP-1, SHP-1L, SH-PTP1
  • Links
    NCBI Gene ID: 5777
    neXtProt AC: NX_P29350

  • Chr Location
    12p13; chr12:6946576-6961316 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    110 phenotypes from 10 alleles in 14 genetic backgrounds
    12 phenotypes from multigenic genotypes
    3 images
    168 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    5
  • Gene trapped
    3
  • Spontaneous
    4
  • Targeted
    5
  • Incidental Mutations
Homozygous mutants are immunodeficient and autoimmune and exhibit neutrophilic skin lesions that disrupt hair follicles and give the motheaten appearance. Alleles vary in severity, with death occurring at 6-9 weeks postnatally due to severe pneumonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038210 VEGA Gene Model | MGI Sequence Detail 18008 C57BL/6J ±  kb
transcript OTTMUST00000098375 VEGA | MGI Sequence Detail 2308 Not Applicable  
polypeptide OTTMUSP00000055278 VEGA | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000013461 tyrosine-protein phosphatase non-receptor type 6
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
    IPR000242 PTP type protein phosphatase
    IPR000980 SH2 domain
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 72
    Genomic 3
    cDNA 66
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10672, MGD-MRK-12181
References
more
  • Summaries
    All 248
    Developmental Gene Expression 8
    Gene Ontology 22
    Phenotypes 168
  • Earliest
    J:13520 Green MC, Cribriform degeneration, cri. Mouse News Lett. 1971;45:29
  • Latest
    J:233313 Getahun A, et al., Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 May 2;213(5):751-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory