Hba-x
Gene Detail

Symbol Name ID

Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex MGI:96019

STS

D11Mit53

Synonyms

zeta globin

Feature Type

protein coding gene

Genetic Map

Chromosome 11

18.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr11:32276400-32278116 bp, + strand From VEGA annotation of GRCm38   1717 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 cattle; 2 dog; 2 chicken; 7 zebrafish

Protein SuperFamily: globin
Gene Tree: Hba-x

Human homologs

Human Homolog		HBZ, hemoglobin, zeta
NCBI Gene ID		3050
neXtProt AC		NX_P02008
Human Chr (Location)		16p13.3; chr16:202854-204504 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

Mice homozygous for a null allele show background sensitive prenatal lethality, variation in postnatal size and pallor, reduced litter size, and a thalassemia-like picture with anisocytosis, poikilocytosis, polychromasia, reduced mean corpuscular volume and hemoglobin, and increased platelet count.

 
Human Diseases Modeled Using Mouse Hba-x (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	erythrocyte maturation, negative regulation of transcription from RNA polymerase II promoter, ...
Component	hemoglobin complex
Function	heme binding, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (49)    Tissues (25)    Images (15)
Theiler Stages: 7, 9, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 28

Assay Type	Results
RNA in situ	15
RT-PCR	33
RNase protection	1

cDNA source data(100)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(119) Genomic(6) cDNA(101) Primer pair(7) Other(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005373 (Evidence)
Ensembl Gene Model	ENSMUSG00000055609 (Evidence)
Entrez Gene	15126 (Evidence)
UniGene	141758
DFCI	TC1577236
DoTS	DT.495190
NIA Mouse Gene Index	U132669
Consensus CDS Project	CCDS24522.1
International Mouse Knockout Project Status	Hba-x

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005373	VEGA Gene Model | MGI Sequence Detail	1717	C57BL/6J
transcript	OTTMUST00000068456	VEGA | MGI Sequence Detail	579	Not Applicable
polypeptide	OTTMUSP00000034620	VEGA | MGI Sequence Detail	156	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000971	Globin
InterPro	IPR009050	Globin-like
InterPro	IPR012292	Globin, structural domain
InterPro	IPR002338	Haemoglobin, alpha
InterPro	IPR002340	Haemoglobin, zeta
Protein Ontology	PR:000008467	hemoglobin subunit zeta

References

(Earliest) J:6586 Leder A, et al., Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature. 1981 Sep 17-23;293(5829):196-200
(Latest) J:188116 Dobreva MP, et al., Periostin as a biomarker of the amniotic membrane. Stem Cells Int. 2012;2012:987185
All references(77)

Other accession IDs

MGD-MRK-10631, MGI:2144168