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Hba-x Gene Detail
Summary
  • Symbol
    Hba-x
  • Name
    hemoglobin X, alpha-like embryonic chain in Hba complex
  • Synonyms
    zeta globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96019
    NCBI Gene: 15126
  • Member of
    Hba cluster
  • Gene Overview
    MyGene.info: HBZ
Location & Maps
more
  • Sequence Map
    Chr11:32276400-32278116 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1717 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HBZ, hemoglobin subunit zeta
  • Vertebrate Orthologs
    23
  • Human Ortholog
    HBZ, hemoglobin subunit zeta
    Orthology source: HomoloGene
  • Synonyms
    HBZ1, HBZ-T1
  • Links
    NCBI Gene ID: 3050
    neXtProt AC: NX_P02008

  • Chr Location
    16p13.3; chr16:142053-154505 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hba-x mouse models

Human Disease Mouse Models
       Hemoglobin--Alpha Locus 1; HBA1   OMIM: 141800 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Hba-x
Mice homozygous for a null allele show background sensitive prenatal lethality, variation in postnatal size and pallor, reduced litter size, and a thalassemia-like picture with anisocytosis, poikilocytosis, polychromasia, reduced mean corpuscular volume and hemoglobin, and increased platelet count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005373 VEGA Gene Model | MGI Sequence Detail 1717 C57BL/6J ±  kb
transcript OTTMUST00000068456 VEGA | MGI Sequence Detail 579 Not Applicable  
polypeptide OTTMUSP00000034620 VEGA | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    Genomic 6
    cDNA 101
    Primer pair 7
    Other 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10631, MGI:2144168
References
more
  • Summaries
    All 75
    Developmental Gene Expression 39
    Diseases 4
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:6586 Leder A, et al., Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature. 1981 Sep 17-23;293(5829):196-200
  • Latest
    J:204573 Funnell AP, et al., Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol. 2013 Aug;33(15):2976-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory