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Hba-x
Gene Detail
Symbol

Name
ID
Member of
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
MGI:96019
Hba cluster
STS
Synonyms
zeta globin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
18.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:32276400-32278116 bp, + strand
From VEGA annotation of GRCm38

  1717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 dog; 2 chicken; 8 western clawed frog; 7 zebrafish

HCOP human homology predictions: HBZ
Protein SuperFamily: globin
Gene Tree: Hba-x

Human
homologs
HBZ, hemoglobin, zeta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3050
neXtProt AC: NX_P02008

Human Synonyms: HBZ1, HBZ-T1

Human Chr (Location): 16p13.3; chr16:142053-154505 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
 
Mice homozygous for a null allele show background sensitive prenatal lethality, variation in postnatal size and pallor, reduced litter size, and a thalassemia-like picture with anisocytosis, poikilocytosis, polychromasia, reduced mean corpuscular volume and hemoglobin, and increased platelet count.
 
Human Diseases Modeled in Mice Using Hba-x (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hba-x interacts with 12 markers (Mir133b, Mir138-1, Mir138-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (39 records)
Data Summary: Results (49)    Tissues (25)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 33
RNase protection 1
cDNA source data(100)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA HBZ    NEW 
Molecular
reagents
All nucleic(119) Genomic(6) cDNA(101) Primer pair(7) Other(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005373 (Evidence)
Ensembl Gene Model ENSMUSG00000055609 (Evidence)
Entrez Gene 15126 (Evidence)
UniGene 141758
DFCI TC1577236
DoTS DT.495190
NIA Mouse Gene Index U132669
Consensus CDS Project CCDS24522.1
International Mouse Phenotyping Consortium Status Hba-x
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005373 VEGA Gene Model | MGI Sequence Detail 1717 C57BL/6J ±  kb
transcript OTTMUST00000068456 VEGA | MGI Sequence Detail 579 Not Applicable 
polypeptide OTTMUSP00000034620 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000971 Globin
InterPro IPR009050 Globin-like
InterPro IPR012292 Globin/Protoglobin
InterPro IPR002338 Haemoglobin, alpha
InterPro IPR002340 Haemoglobin, zeta
Protein Ontology PR:000008467 hemoglobin subunit zeta
References
(Earliest) J:6586 Leder A, et al., Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature. 1981 Sep 17-23;293(5829):196-200
(Latest) J:204573 Funnell AP, et al., Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol. 2013 Aug;33(15):2976-87
All references(78)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10631, MGI:2144168

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory