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Hba-a2 Gene Detail
Summary
  • Symbol
    Hba-a2
  • Name
    hemoglobin alpha, adult chain 2
  • Synonyms
    alpha 2 globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96016
    NCBI Gene: 110257
  • Member of
    Hba cluster
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32296489-32297298 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 18.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96016
protein coding gene Chr11:32296489-32297310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023398
protein coding gene Chr17:25447654-25448436 (-)
A/J MGP_AJ_G0023357
protein coding gene Chr17:24681901-24682683 (-)
AKR/J MGP_AKRJ_G0023323
protein coding gene Chr17:24794852-24795634 (-)
BALB/cJ MGP_BALBcJ_G0023362
protein coding gene Chr17:24904144-24904926 (-)
C3H/HeJ MGP_C3HHeJ_G0023122
protein coding gene Chr17:25185887-25186669 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018529
protein coding gene Chr11:31518681-31519490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016182
protein coding gene Chr11:27863533-27864340 (+)
CAST/EiJ MGP_CASTEiJ_G0022624
protein coding gene Chr17:25108219-25109001 (-)
CBA/J MGP_CBAJ_G0023097
protein coding gene Chr17:27457961-27458743 (-)
DBA/2J MGP_DBA2J_G0023227
protein coding gene Chr17:24274779-24275561 (-)
FVB/NJ MGP_FVBNJ_G0023197
protein coding gene Chr17:24037705-24038487 (-)
LP/J MGP_LPJ_G0023304
protein coding gene Chr17:25721114-25721896 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023216
protein coding gene Chr17:27016862-27017644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023844
protein coding gene Chr17:25152176-25152958 (-)
PWK/PhJ MGP_PWKPhJ_G0022373
protein coding gene Chr17:23048828-23049610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022191
protein coding gene Chr17:23209452-23210239 (-)
WSB/EiJ MGP_WSBEiJ_G0022687
protein coding gene Chr17:25176321-25177104 (-)



Homology
more
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECYT7, HBA-T3, HBH, METHBA
  • Links
    NCBI Gene ID: 3039
    neXtProt AC: NX_P69905
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:176651-177522 (+)  GRCh38.p7

  • Human Ortholog
    HBA2, hemoglobin subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECYT7, HBA-T2, HBH
  • Links
    NCBI Gene ID: 3040
    neXtProt AC: NX_P69905
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:172847-173710 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human HBA1,HBA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    63 phenotypes from multigenic genotypes
    102 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Transgenic
    5
  • Genomic Mutations
    3 involving Hba-a2
  • Find Mice (IMSR)
Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069917 Ensembl Gene Model | MGI Sequence Detail 810 C57BL/6J ±  kb
transcript ENSMUST00000093207 Ensembl | MGI Sequence Detail 554 Not Applicable  
polypeptide ENSMUSP00000090895 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 27
    Genomic 5
    cDNA 15
    Primer pair 1
    Other 6

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10627
References
more
  • Summaries
    All 132
    Developmental Gene Expression 7
    Diseases 7
    Gene Ontology 4
    Phenotypes 102
  • Earliest
    J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
  • Latest
    J:256800 Lei J, et al., Comparative Analysis of Pain Behaviours in Humanized Mouse Models of Sickle Cell Anemia. PLoS One. 2016;11(8):e0160608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/15/2019
MGI 6.13
The Jackson Laboratory