Hba-a2 MGI Mouse Gene Detail - MGI:96016 - hemoglobin alpha, adult chain 2

Symbol

Hba-a2
Name

hemoglobin alpha, adult chain 2
Synonyms

alpha 2 globin

Feature Type

protein coding gene
IDs

MGI:96016
NCBI Gene: 110257
Member of

Hba cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:32246489-32247298 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 18.87 cM
Mapping Data

3 experiments

SNPs within 2kb

32 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96016	protein coding gene	Chr11:32246489-32247310 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023398	protein coding gene	Chr17:25447654-25448436 (-)
A/J	MGP_AJ_G0023357	protein coding gene	Chr17:24681901-24682683 (-)
AKR/J	MGP_AKRJ_G0023323	protein coding gene	Chr17:24794852-24795634 (-)
BALB/cJ	MGP_BALBcJ_G0023362	protein coding gene	Chr17:24904144-24904926 (-)
C3H/HeJ	MGP_C3HHeJ_G0023122	protein coding gene	Chr17:25185887-25186669 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018529	protein coding gene	Chr11:31518681-31519490 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016182	protein coding gene	Chr11:27863533-27864340 (+)
CAST/EiJ	MGP_CASTEiJ_G0022624	protein coding gene	Chr17:25108219-25109001 (-)
CBA/J	MGP_CBAJ_G0023097	protein coding gene	Chr17:27457961-27458743 (-)
DBA/2J	MGP_DBA2J_G0023227	protein coding gene	Chr17:24274779-24275561 (-)
FVB/NJ	MGP_FVBNJ_G0023197	protein coding gene	Chr17:24037705-24038487 (-)
LP/J	MGP_LPJ_G0023304	protein coding gene	Chr17:25721114-25721896 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023216	protein coding gene	Chr17:27016862-27017644 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023844	protein coding gene	Chr17:25152176-25152958 (-)
PWK/PhJ	MGP_PWKPhJ_G0022373	protein coding gene	Chr17:23048828-23049610 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022191	protein coding gene	Chr17:23209452-23210239 (-)
WSB/EiJ	MGP_WSBEiJ_G0022687	protein coding gene	Chr17:25176321-25177104 (-)

Human Ortholog

HBA1, hemoglobin subunit alpha 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HBA1, hemoglobin subunit alpha 1
Synonyms

ECYT7, HBA-T3, HBH, METHBA
Links

HGNC:4823

NCBI Gene ID: 3039

neXtProt AC: NX_P69905

UniProt: P69905
Chr Location

16p13.3; chr16:176680-177522 (+) GRCh38

Human Ortholog

HBA2, hemoglobin subunit alpha 2
Synonyms

ECYT7, HBA-T2, HBH
Links

HGNC:4824

NCBI Gene ID: 3040

neXtProt AC: NX_P69905

UniProt: P69905
Chr Location

16p13.3; chr16:172876-173710 (+) GRCh38

MGI Vertebrate Homology

Hba-a2 stringent orthology
2 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: HBA1, HBA2
Gene Tree

Hba-a2

Diseases

4 with human HBA1,HBA2 associations

Human Disease

Mouse Models

alpha thalassemia

IDs

View 7 models

familial erythrocytosis 7

IDs

Heinz body anemia

IDs

hemoglobin H disease

IDs

Click on a disease name to see all genes associated with that disease.

References

8 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
179 phenotype references

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

3
Targeted

2
Genomic Mutations

6 involving Hba-a2
Find Mice (IMSR)

3 strains or lines available

Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

3
cDNA Data

13
Literature Summary

8

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hbaa1

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All Sequences

41
RefSeq

2
CCDS

CCDS48766.1

Ensembl

ENSMUSG00000069917 (Evidence)
NCBI Gene

110257

			Length	Strain/Species	Flank
genomic	ENSMUSG00000069917	Ensembl Gene Model \| MGI Sequence Detail	810	C57BL/6J	± kb
transcript	ENSMUST00000093207	Ensembl \| MGI Sequence Detail	554	Not Applicable
polypeptide	ENSMUSP00000090895	Ensembl \| MGI Sequence Detail	142	Not Applicable

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All nucleic 27

Genomic 5

cDNA 15

Primer pair 1

Other 6

Microarray probesets 1

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MGD-MRK-10627

Summaries

All 207

Developmental Gene Expression 8

Diseases 8

Gene Ontology 3

Phenotypes 179
Earliest

J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
Latest

J:345251 Cendali FI, et al., Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023;14:1151268

TSS for Hba-a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100842	Chr11:32246491-32246492 (+)	3 bp
Tssr100843	Chr11:32247127-32247159 (+)	654 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23