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Hba-a2 Gene Detail
Summary
  • Symbol
    Hba-a2
  • Name
    hemoglobin alpha, adult chain 2
  • Synonyms
    alpha 2 globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96016
    NCBI Gene: 110257
  • Member of
    Hba cluster
Location & Maps
more
  • Sequence Map
    Chr11:32296489-32297298 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      810 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBA-T3, HBH
  • Links
    NCBI Gene ID: 3039
    neXtProt AC: NX_P69905

  • Chr Location
    16p13.3; chr16:176651-177522 (+)  GRCh38.p2

  • Human Ortholog
    HBA2, hemoglobin subunit alpha 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBA-T2, HBH
  • Links
    NCBI Gene ID: 3040
    neXtProt AC: NX_P69905

  • Chr Location
    16p13.3; chr16:172847-173710 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human HBA1,HBA2 associations

Human Disease Mouse Models
       Alpha-Thalassemia   OMIM: 604131
Heinz Body Anemias   OMIM: 140700
Hemoglobin H Disease; HBH   OMIM: 613978
Hemoglobin--Alpha Locus 1; HBA1   OMIM: 141800 View 8 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    15 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    63 phenotypes from multigenic genotypes
    91 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Transgenic
    5
  • Genomic Mutations
    3 involving Hba-a2
Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005376 VEGA Gene Model | MGI Sequence Detail 810 C57BL/6J ±  kb
transcript OTTMUST00000011990 VEGA | MGI Sequence Detail 554 Not Applicable  
polypeptide OTTMUSP00000005552 VEGA | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    47 from dbSNP Build 137
  • RFLP
Molecular
Reagents
less
  • All nucleic 27
    Genomic 5
    cDNA 15
    Primer pair 1
    Other 6

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10627
References
more
  • Summaries
    All 29
    Developmental Gene Expression 6
    Diseases 15
    Gene Ontology 3
    Phenotypes 91
  • Earliest
    J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
  • Latest
    J:182447 Jiang Z, et al., Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory