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Hba-a2
Gene Detail
Symbol

Name
ID
Member of
Hba-a2
hemoglobin alpha, adult chain 2
MGI:96016
Hba cluster
Synonyms
alpha 2 globin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
18.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:32296489-32297298 bp, + strand
From VEGA annotation of GRCm38

  810 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:469  Vertebrate Homology Class
2 human; 2 mouse; 1 rat; 2 rhesus macaque; 2 cattle; 2 dog; 2 chicken; 1 western clawed frog

Protein SuperFamily: globin
Gene Tree: Hba-a2

Human
homologs
Human Homolog HBA1, hemoglobin, alpha 1
NCBI Gene ID 3039
neXtProt AC  NX_P69905
Human Synonyms  HBA-T3, HBH
Human Chr (Location)  16p13.3; chr16:176680-177521 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human HBA1
Human Homolog HBA2, hemoglobin, alpha 2
NCBI Gene ID 3040
neXtProt AC  NX_P69905
Human Synonyms  HBA-T2, HBH
Human Chr (Location)  16p13.3; chr16:172847-173710 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human HBA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Radiation induced(1)
 
Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.
 
Interactions
Hba-a2 interacts with 14 markers (Mir125a, Mir185, Mir186, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process erythrocyte development, in utero embryonic development
Component blood microparticle, cytosolic small ribosomal subunit, ...
Function haptoglobin binding, peroxidase activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 4
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(5) cDNA(15) Primer pair(1) Other(6)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000005376 (Evidence)
Ensembl Gene ModelENSMUSG00000069917 (Evidence)
Entrez Gene110257 (Evidence)
Consensus CDS ProjectCCDS48766.1
International Mouse Knockout Project StatusHba-a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005376 VEGA Gene Model | MGI Sequence Detail 810 C57BL/6J ±  kb
transcript OTTMUST00000011990 VEGA | MGI Sequence Detail 554 Not Applicable 
polypeptide OTTMUSP00000005552 VEGA | MGI Sequence Detail 142 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(40 from dbSNP Build 137)    SNPs within 2kb including multiple locations(68)
References
(Earliest) J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
(Latest) J:182447 Jiang Z, et al., Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87
All references(28)
Other
accession IDs
MGD-MRK-10627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory