Hba-a2
Gene Detail

Symbol Name ID

Hba-a2 hemoglobin alpha, adult chain 2 MGI:96016

Synonyms

alpha 2 globin

Feature Type

protein coding gene

Genetic Map

Chromosome 11

18.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:32296489-32297298 bp, + strand From VEGA annotation of GRCm38   810 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:469  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 2 rhesus macaque; 2 cattle; 2 dog; 2 chicken

Protein SuperFamily: globin
Gene Tree: Hba-a2

Human homologs

Human Homolog		HBA1, hemoglobin, alpha 1
NCBI Gene ID		3039
neXtProt AC		NX_P69905
Human Synonyms		CD31, HBH
Human Chr (Location)		16p13.3; chr16:226679-227520 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human HBA1
Human Homolog		HBA2, hemoglobin, alpha 2
NCBI Gene ID		3040
neXtProt AC		NX_P69905
Human Synonyms		HBH
Human Chr (Location)		16p13.3; chr16:222846-223709 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human HBA2

Alleles and phenotypes

All alleles(1) : Radiation induced(1)
 

Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	erythrocyte development, in utero embryonic development
Component	cytosolic small ribosomal subunit, haptoglobin-hemoglobin complex, ...
Function	beta-amyloid binding, haptoglobin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (2)   
Theiler Stages: 17, 22

Assay Type	Results
RT-PCR	4

cDNA source data(14)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(5) cDNA(15) Primer pair(1) Other(6)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000005376 (Evidence)
Ensembl Gene Model	ENSMUSG00000069917 (Evidence)
Entrez Gene	110257 (Evidence)
Consensus CDS Project	CCDS48766.1
International Mouse Knockout Project Status	Hba-a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005376	VEGA Gene Model | MGI Sequence Detail	810	C57BL/6J
transcript	OTTMUST00000011990	VEGA | MGI Sequence Detail	554	Not Applicable
polypeptide	OTTMUSP00000005552	VEGA | MGI Sequence Detail	142	Not Applicable

All sequences(29) RefSeq(2)

Polymorphisms

RFLP(6) : SNPs(0 from dbSNP Build 128)

References

(Earliest) J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
(Latest) J:182447 Jiang Z, et al., Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87
All references(29)

Other accession IDs

MGD-MRK-10627