Hba-a1
Gene Detail

Symbol Name ID

Hba-a1 hemoglobin alpha, adult chain 1 MGI:96015

Synonyms

alpha 1 globin, Hba1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

18.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:32283511-32284465 bp, + strand From VEGA annotation of GRCm38   955 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Hba-a1 ± 2 cM)

Protein SuperFamily: globin
Gene Tree: Hba-a1

Human ortholog

HBA2 hemoglobin, alpha 2 NCBI Gene ID 3040
Human Synonyms: HBH
Human Chr16:222846-223709 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human HBA2 (3)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes in which both adult hemoglobin-alpha genes are deleted die late in gestation with symptoms resembling human hydrops fetalis. Allele and strain dependent erythrocyte and hemoglobin anomalies are seen in alpha1 homo- and heterozygous mutants.

 
Human Diseases Modeled Using Mouse Hba-a1 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (2 annotations)

Process

erythrocyte development, in utero embryonic development

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (67)    Tissues (21)    Images (5)
Theiler Stages: 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	4
RT-PCR	62

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(6) cDNA(24) Primer pair(6) Other(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005377 (Evidence)
Ensembl Gene Model	ENSMUSG00000069919 (Evidence)
Entrez Gene	15122 (Evidence)
Consensus CDS Project	CCDS24523.1
International Mouse Knockout Project Status	Hba-a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005377	VEGA Gene Model | MGI Sequence Detail	955	C57BL/6J
transcript	OTTMUST00000011991	VEGA | MGI Sequence Detail	699	Not Applicable
polypeptide	OTTMUSP00000005553	VEGA | MGI Sequence Detail	142	Not Applicable

All sequences(39) RefSeq(2)

Polymorphisms

RFLP(3) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000008856	hemoglobin subunit alpha

References

(Earliest) J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
(Latest) J:190978 Straub AC, et al., Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling. Nature. 2012 Nov 15;491(7424):473-7
All references(68)

Other accession IDs

MGD-MRK-10626