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Hba-a1
Gene Detail
 Symbol
Name
ID
Hba-a1
hemoglobin alpha, adult chain 1
MGI:96015
Synonyms alpha 1 globin, Hba1
Feature Type protein coding gene
Genetic Map
Chromosome 11
18.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:32283511-32284465 bp, + strand
From VEGA annotation of GRCm38

  955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:469  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 2 rhesus macaque; 2 cattle; 2 dog; 2 chicken

Protein SuperFamily: globin
Gene Tree: Hba-a1

Human
homologs
Human Homolog HBA1, hemoglobin, alpha 1
NCBI Gene ID 3039
neXtProt AC  NX_P69905
Human Synonyms  HBH
Human Chr (Location)  16p13.3; chr16:176680-177521 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human HBA1
Human Homolog HBA2, hemoglobin, alpha 2
NCBI Gene ID 3040
neXtProt AC  NX_P69905
Human Synonyms  HBH
Human Chr (Location)  16p13.3; chr16:172847-173710 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human HBA2
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygotes in which both adult hemoglobin-alpha genes are deleted die late in gestation with symptoms resembling human hydrops fetalis. Allele and strain dependent erythrocyte and hemoglobin anomalies are seen in alpha1 homo- and heterozygous mutants.
 
Human Diseases Modeled Using Mouse Hba-a1 (2)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process erythrocyte development, in utero embryonic development
Component blood microparticle, cytosolic small ribosomal subunit, ...
Function beta-amyloid binding, haptoglobin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (67)    Tissues (21)    Images (5)
Theiler Stages: 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 26, 28
Assay TypeResults
RNA in situ 1
Northern blot 4
RT-PCR 62
cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) Genomic(6) cDNA(24) Primer pair(6) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005377 (Evidence)
Ensembl Gene ModelENSMUSG00000069919 (Evidence)
Entrez Gene15122 (Evidence)
Consensus CDS ProjectCCDS24523.1
International Mouse Knockout Project StatusHba-a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005377 VEGA Gene Model | MGI Sequence Detail 955 C57BL/6J ±  kb
transcript OTTMUST00000011991 VEGA | MGI Sequence Detail 699 Not Applicable 
polypeptide OTTMUSP00000005553 VEGA | MGI Sequence Detail 142 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2)
Polymorphisms RFLP(3) : SNPs within 2kb(30 from dbSNP Build 137)    SNPs within 2kb including multiple locations(58)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008856 hemoglobin subunit alpha
References (Earliest) J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
(Latest) J:190978 Straub AC, et al., Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling. Nature. 2012 Nov 15;491(7424):473-7
All references(70)
Other
accession IDs
MGD-MRK-10626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory