Hba-a1
Gene Detail

Symbol Name ID

Hba-a1 hemoglobin alpha, adult chain 1 MGI:96015

Synonyms

alpha 1 globin, Hba1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

18.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:32283511-32284465 bp, + strand From VEGA annotation of GRCm38   955 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:469  Vertebrate Homology Class
2 human; 2 mouse; 2 rat; 2 rhesus macaque; 2 cattle; 2 dog; 2 chicken

Protein SuperFamily: globin
Gene Tree: Hba-a1

Human homologs

Human Homolog		HBA1, hemoglobin, alpha 1
NCBI Gene ID		3039
neXtProt AC		NX_P69905
Human Synonyms		CD31, HBH
Human Chr (Location)		16p13.3; chr16:226679-227520 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human HBA1
Human Homolog		HBA2, hemoglobin, alpha 2
NCBI Gene ID		3040
neXtProt AC		NX_P69905
Human Synonyms		HBH
Human Chr (Location)		16p13.3; chr16:222846-223709 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human HBA2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes in which both adult hemoglobin-alpha genes are deleted die late in gestation with symptoms resembling human hydrops fetalis. Allele and strain dependent erythrocyte and hemoglobin anomalies are seen in alpha1 homo- and heterozygous mutants.

 
Human Diseases Modeled Using Mouse Hba-a1 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	erythrocyte development, in utero embryonic development
Component	cytosolic small ribosomal subunit, haptoglobin-hemoglobin complex, ...
Function	beta-amyloid binding, haptoglobin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (67)    Tissues (21)    Images (5)
Theiler Stages: 7, 9, 11, 13, 15, 17, 19, 20, 21, 22, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	4
RT-PCR	62

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(6) cDNA(24) Primer pair(6) Other(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005377 (Evidence)
Ensembl Gene Model	ENSMUSG00000069919 (Evidence)
Entrez Gene	15122 (Evidence)
Consensus CDS Project	CCDS24523.1
International Mouse Knockout Project Status	Hba-a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005377	VEGA Gene Model | MGI Sequence Detail	955	C57BL/6J
transcript	OTTMUST00000011991	VEGA | MGI Sequence Detail	699	Not Applicable
polypeptide	OTTMUSP00000005553	VEGA | MGI Sequence Detail	142	Not Applicable

All sequences(39) RefSeq(2)

Polymorphisms

RFLP(3) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000008856	hemoglobin subunit alpha

References

(Earliest) J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
(Latest) J:190978 Straub AC, et al., Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling. Nature. 2012 Nov 15;491(7424):473-7
All references(70)

Other accession IDs

MGD-MRK-10626