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Hadh
Gene Detail
 Symbol
Name
ID
Hadh
hydroxyacyl-Coenzyme A dehydrogenase
MGI:96009
Synonyms Hadhsc, Schad
Feature Type protein coding gene
Genetic Map
Chromosome 3
60.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:131233419-131272101 bp, - strand
From VEGA annotation of GRCm38

  38683 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3-hydroxyacyl-CoA dehydrogenase
Gene Tree: Hadh

Human
homologs
Human Homolog HADH, hydroxyacyl-CoA dehydrogenase
NCBI Gene ID 3033
neXtProt AC  NX_Q16836
Human Synonyms  HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
Human Chr (Location)  4q22-q26; chr4:107989714-108035175 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HADH
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit decreased susceptibility to diet-induced obesity associated with impaired fatty acid oxidation, impaired fat tolerance, decreased ketone bodies, and increased glucose-stimulated insulin secretion.
 
Phenotype Images(1)
Interactions
Hadh interacts with 80 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process, ...
Component cytoplasm, mitochondrial inner membrane, ...
Function 3-hydroxyacyl-CoA dehydrogenase activity, coenzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (259)    Tissues (165)    Images (38)
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 213
RT-PCR 46
cDNA source data(204)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(207) cDNA(205) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028850 (Evidence)
Ensembl Gene ModelENSMUSG00000027984 (Evidence)
Entrez Gene15107 (Evidence)
UniGene260164
DFCITC1573429
DoTSDT.103565808, DT.537104, DT.99863760
NIA Mouse Gene IndexU024654
EC1.1.1.35
Consensus CDS ProjectCCDS38640.1
International Mouse Knockout Project StatusHadh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028850 VEGA Gene Model | MGI Sequence Detail 38683 C57BL/6J ±  kb
transcript OTTMUST00000071450 VEGA | MGI Sequence Detail 1789 Not Applicable 
polypeptide OTTMUSP00000036612 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022694 3-hydroxyacyl-CoA dehydrogenase
InterPro IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
InterPro IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
InterPro IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
InterPro IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
InterPro IPR013328 Dehydrogenase, multihelical
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008432 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
References (Earliest) J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
(Latest) J:187103 Narayan SB, et al., Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS One. 2012;7(4):e35048
All references(47)
Other
accession IDs
MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory