Hadh
Gene Detail

Symbol Name ID

Hadh hydroxyacyl-Coenzyme A dehydrogenase MGI:96009

Synonyms

Hadhsc, Schad

Feature Type

protein coding gene

Genetic Map

Chromosome 3

60.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:131233419-131272101 bp, - strand From VEGA annotation of GRCm38   38683 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3-hydroxyacyl-CoA dehydrogenase
Gene Tree: Hadh

Human homologs

Human Homolog		HADH, hydroxyacyl-CoA dehydrogenase
NCBI Gene ID		3033
neXtProt AC		NX_Q16836
Human Synonyms		HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
Human Chr (Location)		4q22-q26; chr4:108910870-108956331 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HADH

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Mice homozygous for a gene trap allele exhibit decreased susceptibility to diet-induced obesity associated with impaired fatty acid oxidation, impaired fat tolerance, decreased ketone bodies, and increased glucose-stimulated insulin secretion.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	fatty acid beta-oxidation, fatty acid metabolic process, ...
Component	cytoplasm, mitochondrial inner membrane, ...
Function	3-hydroxyacyl-CoA dehydrogenase activity, coenzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (259)    Tissues (164)    Images (38)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	213
RT-PCR	46

cDNA source data(205)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(208) cDNA(206) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028850 (Evidence)
Ensembl Gene Model	ENSMUSG00000027984 (Evidence)
Entrez Gene	15107 (Evidence)
UniGene	260164
DFCI	TC1573429
DoTS	DT.537104, DT.99863760
NIA Mouse Gene Index	U024654
EC	1.1.1.35
Consensus CDS Project	CCDS38640.1
International Mouse Knockout Project Status	Hadh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028850	VEGA Gene Model | MGI Sequence Detail	38683	C57BL/6J
transcript	OTTMUST00000071450	VEGA | MGI Sequence Detail	1789	Not Applicable
polypeptide	OTTMUSP00000036612	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(38) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(305 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022694	3-hydroxyacyl-CoA dehydrogenase
InterPro	IPR006180	3-hydroxyacyl-CoA dehydrogenase, conserved site
InterPro	IPR006108	3-hydroxyacyl-CoA dehydrogenase, C-terminal
InterPro	IPR006176	3-hydroxyacyl-CoA dehydrogenase, NAD binding
InterPro	IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
InterPro	IPR013328	Dehydrogenase, multihelical
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000008432	hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

References

(Earliest) J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
(Latest) J:187103 Narayan SB, et al., Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS One. 2012;7(4):e35048
All references(47)

Other accession IDs

MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013