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Hadh Gene Detail
Summary
  • Symbol
    Hadh
  • Name
    hydroxyacyl-Coenzyme A dehydrogenase
  • Synonyms
    Hadhsc, Schad
  • Feature Type
    protein coding gene
  • IDs
    MGI:96009
    NCBI Gene: 15107
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:131233419-131272101 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 60.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96009
protein coding gene Chr3:131233419-131272101 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027886
protein coding gene Chr3:134029430-134068092 (-)
A/J MGP_AJ_G0027844
protein coding gene Chr3:129302938-129341594 (-)
AKR/J MGP_AKRJ_G0027809
protein coding gene Chr3:132671788-132712966 (-)
BALB/cJ MGP_BALBcJ_G0027857
protein coding gene Chr3:129158952-129197618 (-)
C3H/HeJ MGP_C3HHeJ_G0027586
protein coding gene Chr3:133077372-133117443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028300
protein coding gene Chr3:138750215-138788900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025638
protein coding gene Chr3:124821795-124862305 (-)
CAST/EiJ MGP_CASTEiJ_G0027042
protein coding gene Chr3:132798103-132839222 (-)
CBA/J MGP_CBAJ_G0027562
protein coding gene Chr3:143417057-143455707 (-)
DBA/2J MGP_DBA2J_G0027702
protein coding gene Chr3:128506651-128545476 (-)
FVB/NJ MGP_FVBNJ_G0027669
protein coding gene Chr3:126086145-126125931 (-)
LP/J MGP_LPJ_G0027812
protein coding gene Chr3:135504096-135542778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027700
protein coding gene Chr3:151343370-151383447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028358
protein coding gene Chr3:132355947-132394628 (-)
PWK/PhJ MGP_PWKPhJ_G0026766
protein coding gene Chr3:128250083-128290809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026591
protein coding gene Chr3:130396497-130436478 (-)
WSB/EiJ MGP_WSBEiJ_G0027121
protein coding gene Chr3:133084975-133125390 (-)



Homology
more
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
  • Links
    NCBI Gene ID: 3033
    neXtProt AC: NX_Q16836
    UniProt: Q16836

  • Chr Location
    4q25; chr4:107989714-108035175 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HADH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased susceptibility to diet-induced obesity associated with impaired fatty acid oxidation, impaired fat tolerance, decreased ketone bodies, and increased glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15107 NCBI Gene Model | MGI Sequence Detail 38683 C57BL/6J ±  kb
    transcript NM_008212 RefSeq | MGI Sequence Detail 1801 C57BL/6  
    polypeptide Q61425 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008432 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR022694 3-hydroxyacyl-CoA dehydrogenase
      IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
      IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
      IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR036291 NAD(P)-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 208
      cDNA 206
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory