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Hadh Gene Detail
Summary
  • Symbol
    Hadh
  • Name
    hydroxyacyl-Coenzyme A dehydrogenase
  • Synonyms
    Hadhsc, Schad
  • Feature Type
    protein coding gene
  • IDs
    MGI:96009
    NCBI Gene: 15107
Location & Maps
more
  • Sequence Map
    Chr3:131233419-131272101 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38683 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
    Orthology source: HomoloGene
  • Synonyms
    HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
  • Links
    NCBI Gene ID: 3033
    neXtProt AC: NX_Q16836

  • Chr Location
    4q22-q26; chr4:107989714-108035175 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human HADH associations

Human Disease Mouse Models
       3-hydroxyacyl-Coa Dehydrogenase Deficiency   OMIM: 231530
Hyperinsulinemic Hypoglycemia, Familial, 4; HHF4   OMIM: 609975
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Hadh
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit decreased susceptibility to diet-induced obesity associated with impaired fatty acid oxidation, impaired fat tolerance, decreased ketone bodies, and increased glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028850 VEGA Gene Model | MGI Sequence Detail 38683 C57BL/6J ±  kb
transcript OTTMUST00000071450 VEGA | MGI Sequence Detail 1789 Not Applicable  
polypeptide OTTMUSP00000036612 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    402 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008432 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR022694 3-hydroxyacyl-CoA dehydrogenase
    IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
    IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
    IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
    IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
    IPR013328 6-phosphogluconate dehydrogenase, domain 2
    IPR016040 NAD(P)-binding domain
Molecular
Reagents
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  • All nucleic 207
    cDNA 205
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
  • Latest
    J:187103 Narayan SB, et al., Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS One. 2012;7(4):e35048

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory