Symbol
Name
ID

Hadh
hydroxyacyl-Coenzyme A dehydrogenase
MGI:96009

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Decreased 3-hydroxyacyl-CoA dehydrogenase level

Decreased circulating carnitine concentration

Hypoglycemic seizures

Hypoketotic hypoglycemia

Neonatal hypoglycemia

Abnormal circulating acylcarnitine concentration

Increased circulating free fatty acid level

Hyperammonemia

Elevated circulating C-peptide concentration

Mildly elevated creatine kinase

Elevated circulating hepatic transaminase concentration

Fasting hyperinsulinemia

Hyperinsulinemic hypoglycemia

Lactic acidosis

Hepatic steatosis

Dicarboxylic aciduria

Myoglobinuria

Disease(s) Associated with HADH

familial hyperinsulinemic hypoglycemia 4

Mouse Phenotypes

abnormal fatty acid oxidation

increased insulin secretion

decreased susceptibility to diet-induced obesity

decreased circulating glucose level

increased circulating insulin level

decreased circulating ketone body level

increased circulating free fatty acids level

increased circulating triglyceride level

increased body temperature

abnormal body temperature homeostasis

decreased respiratory quotient

abnormal glucose homeostasis

abnormal lipid homeostasis

abnormal fatty acids level

increased fatty acids level

abnormal urine homeostasis

aciduria

Availability

Mouse Genotype

Hadh^{Gt(RRM279)Byg}/Hadh^{Gt(RRM279)Byg}

Hadh^tm1Csta/Hadh^tm1Csta

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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