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H2-T23 Gene Detail
Summary
  • Symbol
    H2-T23
  • Name
    histocompatibility 2, T region locus 23
  • Synonyms
    37b, 37c, H-2T23, Qa1, Qa-1, Qed-1, T18c, T18c(37), T23b, T23d
  • Feature Type
    protein coding gene
  • IDs
    MGI:95957
    NCBI Gene: 15040
  • Gene Overview
    MyGene.info: HLA-E
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36029977-36032701 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95957
protein coding gene Chr17:36029773-36032855 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023667
protein coding gene Chr17:36253846-36258100 (-)
A/J MGP_AJ_G0023622
protein coding gene Chr17:35159062-35161738 (-)
AKR/J MGP_AKRJ_G0023592
protein coding gene Chr17:35556928-35563213 (-)
BALB/cJ MGP_BALBcJ_G0023627
protein coding gene Chr17:35273521-35378865 (-)
C3H/HeJ MGP_C3HHeJ_G0023393
protein coding gene Chr17:36013867-36021814 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021429
protein coding gene Chr17:30244884-30247704 (-)
CAST/EiJ MGP_CASTEiJ_G0022884
protein coding gene Chr17:36132162-36134723 (-)
CBA/J MGP_CBAJ_G0023371
protein coding gene Chr17:39310825-39323975 (-)
DBA/2J MGP_DBA2J_G0023495
protein coding gene Chr17:34480104-34510253 (-)
FVB/NJ MGP_FVBNJ_G0023466
protein coding gene Chr17:34230731-34231702 (-)
LP/J MGP_LPJ_G0023575
protein coding gene Chr17:36620526-36623717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023487
protein coding gene Chr17:38083352-38088894 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024116
protein coding gene Chr17:35946641-35949484 (-)
PWK/PhJ MGP_PWKPhJ_G0022635
protein coding gene Chr17:33276576-33277696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022454
protein coding gene Chr17:33909422-33926524 (-)
WSB/EiJ MGP_WSBEiJ_G0022950
protein coding gene Chr17:36012551-36017087 (-)



Homology
more
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
    Orthology source: HomoloGene
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489406-30494205 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
CD4+ T cells from mice with a homozygous null mutation have enhanced responses after infection or immunization, are resistant to suppressor activity mediated by a subset of CD8+ T cells, but are more susceptible to NK cell lysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15040 NCBI Gene Model | MGI Sequence Detail 2725 C57BL/6J ±  kb
transcript NM_010398 RefSeq | MGI Sequence Detail 1317 C57BL/6  
polypeptide P06339 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000008412 H-2 class I histocompatibility antigen, D-37 alpha chain
  • PDB
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
less
  • All nucleic 16
    Genomic 3
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10439, MGD-MRK-10553
References
more
  • Summaries
    All 78
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:12076 Stanton TH, et al., A new serologically defined locus, Qa-1, in the Tla-region of the mouse. Immunogenetics. 1976;3:525-531
  • Latest
    J:272693 Linehan JL, et al., Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell. 2018 Feb 8;172(4):784-796.e18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory