Automated description from the Alliance of Genome Resources (Release 6.0.0)
Predicted to enable beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in cell surface and plasma membrane. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E).