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H2-DMa
Gene Detail
Symbol

Name
ID
H2-DMa
histocompatibility 2, class II, locus DMa
MGI:95921
Synonyms
H-2Ma, H2-Ma, H2-M alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:34135182-34139101 bp, + strand
From VEGA annotation of GRCm38

  3920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4464  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

HCOP human homology predictions: HLA-DMA
Gene Tree: H2-DMa

Human
homologs
HLA-DMA, major histocompatibility complex, class II, DM alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3108
neXtProt AC: NX_P28067

Human Synonyms: D6S222E, DMA, HLADM, RING6

Human Chr (Location): 6p21.3; chr6:32948614-32953122 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired antigen presenting cell function, poor IgG responses to T-dependent antigens, reduced numbers of mature CD4+ T cells, and increased susceptibility to Leishmania major infection.
 
Interactions
H2-DMa interacts with 30 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (58)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
RT-PCR 92
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) Genomic(9) cDNA(64) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037115 (Evidence)
Ensembl Gene Model ENSMUSG00000037649 (Evidence)
Entrez Gene 14998 (Evidence)
UniGene 16373
DFCI TC1578634
DoTS DT.94309853, DT.91299890, DT.533879
NIA Mouse Gene Index U017845
PDB 1K8I
Consensus CDS Project CCDS37579.1
International Mouse Phenotyping Consortium Status H2-DMa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037115 VEGA Gene Model | MGI Sequence Detail 3920 C57BL/6J ±  kb
transcript OTTMUST00000095557 VEGA | MGI Sequence Detail 1555 Not Applicable 
polypeptide OTTMUSP00000053322 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(11)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR014745 MHC class II, alpha/beta chain, N-terminal
InterPro IPR001003 MHC class II, alpha chain, N-terminal
Protein Ontology PR:000033943 class II histocompatibility antigen, M alpha chain
References
(Earliest) J:11259 Cho S, et al., A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5197-201
(Latest) J:209799 Persaud SP, et al., Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol. 2014 Mar;15(3):266-74
All references(103)
Other
accession IDs
MGD-MRK-10405, MGD-MRK-10517

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory