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H2-DMa Gene Detail
Summary
  • Symbol
    H2-DMa
  • Name
    histocompatibility 2, class II, locus DMa
  • Synonyms
    H-2Ma, H2-Ma, H2-M alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95921
    NCBI Gene: 14998
  • Gene Overview
    MyGene.info: HLA-DMA
Location & Maps
more
  • Sequence Map
    Chr17:34135182-34139101 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3920 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HLA-DMA, major histocompatibility complex, class II, DM alpha
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HLA-DMA, major histocompatibility complex, class II, DM alpha
    Orthology source: HomoloGene
  • Synonyms
    D6S222E, DMA, HLADM, RING6
  • Links
    NCBI Gene ID: 3108
    neXtProt AC: NX_P28067

  • Chr Location
    6p21.3; chr6:32948614-32953122 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    6
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired antigen presenting cell function, poor IgG responses to T-dependent antigens, reduced numbers of mature CD4+ T cells, and increased susceptibility to Leishmania major infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037115 VEGA Gene Model | MGI Sequence Detail 3920 C57BL/6J ±  kb
transcript OTTMUST00000095557 VEGA | MGI Sequence Detail 1555 Not Applicable  
polypeptide OTTMUSP00000053322 VEGA | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000033943 class II histocompatibility antigen, M alpha chain
  • PDB
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR001003 MHC class II, alpha chain, N-terminal
Molecular
Reagents
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  • All nucleic 74
    Genomic 9
    cDNA 64
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10405, MGD-MRK-10517
References
more
  • Summaries
    All 100
    Developmental Gene Expression 3
    Gene Ontology 17
    Phenotypes 59
  • Earliest
    J:11259 Cho S, et al., A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5197-201
  • Latest
    J:209799 Persaud SP, et al., Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol. 2014 Mar;15(3):266-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory