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Gene Detail
histocompatibility 2, K1, K region
STS D17Mit28
Synonyms H-2K
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM

Mapping data(60)
Sequence Map
Chr17:33996017-34000333 bp, - strand
From VEGA annotation of GRCm38

  4317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-K1

Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
alleles, and
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for disruptions of this gene display T-cell abnormalities and abnormal susceptibility to various viral infections.
H2-K1 interacts with 60 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (45 annotations)
Process antigen processing and presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
External Resources: FuncBase
Literature Summary: (9 records)
Data Summary: Results (33)    Tissues (23)    Images (2)
Theiler Stages: 9, 15, 16, 19, 20, 22, 28
Assay TypeResults
cDNA source data(22)
External Resources: GENSAT   GEO   Expression Atlas
All nucleic(116) Genomic(85) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000037104 (Evidence)
Ensembl Gene ModelENSMUSG00000061232 (Evidence)
Entrez Gene14972 (Evidence)
PDB1BQH, 1FZJ, 1FZK, 1FZM, 1FZO, 1G6R, 1G7P, 1G7Q, 1KBG, 1KPU, 1KPV, 1LEG, 1LEK, 1MWA, 1NAM, 1NAN, 1OSZ, 1P1Z, 1P4L, 1RJY, 1RJZ, 1S7Q, 1S7R, 1S7S, 1S7T, 1T0M, 1T0N, 1VAC, 1VAD, 1VGK, 1WBZ, 2CKB, 2CLV, 2CLZ, 2FWO, 2MHA, 2QRI, 2QRS, 2QRT, 2VAA, 2VAB, 2ZSV, 2ZSW, 3C8K, 3CVH, 3NWM, 3P4M, 3P4N, 3P4O, 3P9L, 3P9M, 3PAB, 3RGV, 3ROL, 3ROO, 3TID, 3TIE, 4HKJ, 1FO0, 1KJ2, 1KJ3, 1LK2, 1N59, 1RK0, 1RK1, 1ZT1, 1ZT7, 2FO4, 2OL3, 4HS3, 4PV8, 4PV9
Consensus CDS ProjectCCDS50069.1
International Mouse Knockout Project StatusH2-K1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037104 VEGA Gene Model | MGI Sequence Detail 4317 C57BL/6J ±  kb
transcript OTTMUST00000095521 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000053302 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(176) RefSeq(40) UniProt(38)
Polymorphisms All PCR and RFLP(24) : PCR(1) RFLP(23) SNPs within 2kb(197 from dbSNP Build 137)    SNPs within 2kb including multiple locations(203)
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR010579 MHC class I, alpha chain, C-terminal
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000002007 H-2 class I histocompatibility antigen K alpha chain
References (Earliest) J:176 Kelly EM, Nonerupted teeth - tl. Mouse News Lett. 1955;12:48
(Latest) J:208658 Bedenikovic G, et al., T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling. Eur J Immunol. 2014 Jan;44(1):115-26
All references(246)
accession IDs
MGD-MRK-10388, MGD-MRK-10500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory