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H2-K1
Gene Detail
Symbol

Name
ID
H2-K1
histocompatibility 2, K1, K region
MGI:95904
STS
Synonyms
H-2K
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(60)
Sequence Map
Chr17:33996017-34000333 bp, - strand
From VEGA annotation of GRCm38

  4317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

HCOP human homology predictions: HLA-A
Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-K1

Human
homologs
HLA-A, major histocompatibility complex, class I, A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3105
neXtProt AC: NX_P04439, NX_P30443

Human Synonyms: HLAA

Human Chr (Location): 6p21.3; chr6:29942470-29945884 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HLA-A

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display T-cell abnormalities and abnormal susceptibility to various viral infections.
 
Human Diseases Modeled in Mice Using H2-K1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
H2-K1 interacts with 60 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (9 records)
Data Summary: Results (33)    Tissues (23)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 33
cDNA source data(22)
Other mouse links: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(85) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000037104 (Evidence)
Ensembl Gene Model ENSMUSG00000061232 (Evidence)
Entrez Gene 14972 (Evidence)
PDB 1BQH, 1FO0, 1FZJ, 1FZK, 1FZM, 1FZO, 1G6R, 1G7P, 1G7Q, 1KBG, 1KJ2, 1KJ3, 1KPU, 1KPV, 1LEG, 1LEK, 1LK2, 1MWA, 1N59, 1NAM, 1NAN, 1OSZ, 1P1Z, 1P4L, 1RJY, 1RJZ, 1RK0, 1RK1, 1S7Q, 1S7R, 1S7S, 1S7T, 1T0M, 1T0N, 1VAC, 1VAD, 1VGK, 1WBZ, 1ZT1, 1ZT7, 2CKB, 2CLV, 2CLZ, 2FO4, 2FWO, 2MHA, 2OL3, 2QRI, 2QRS, 2QRT, 2VAA, 2VAB, 2ZSV, 2ZSW, 3C8K, 3CVH, 3NWM, 3P4M, 3P4N, 3P4O, 3P9L, 3P9M, 3PAB, 3RGV, 3ROL, 3ROO, 3TID, 3TIE, 4HKJ, 4HS3, 4PG9, 4PGB, 4PGC, 4PGD, 4PGE, 4PV8, 4PV9
Consensus CDS Project CCDS50069.1
International Mouse Phenotyping Consortium Status H2-K1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037104 VEGA Gene Model | MGI Sequence Detail 4317 C57BL/6J ±  kb
transcript OTTMUST00000095521 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000053302 VEGA | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(168) RefSeq(30) UniProt(39)
Polymorphisms
All PCR and RFLP(24) : PCR(1) RFLP(23) SNPs within 2kb(197 from dbSNP Build 137)    SNPs within 2kb including multiple locations(203)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR010579 MHC class I, alpha chain, C-terminal
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000002007 H-2 class I histocompatibility antigen K alpha chain
References
(Earliest) J:176 Kelly EM, Nonerupted teeth - tl. Mouse News Lett. 1955;12:48
(Latest) J:222732 Rouhani SJ, et al., Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771
All references(253)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10388, MGD-MRK-10500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory