Tg(tetO-H2-K1)#Papl
Transgene Detail

Summary

• Symbol: Tg(tetO-H2-K1)#Papl
• Name: transgene insertion, Paul Plotz
• MGI ID: MGI:5547617
• Synonyms: TRE-H-2K^b
• Transgene: Tg(tetO-H2-K1)#Papl Location: unknown
• Alliance: Tg(tetO-H2-K1)#Papl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-H2-K1)#Papl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-K1 (MGI:95904)

• Mutation details: The tetracycline-responsive element drives the expression of murine H2-K1^b. Crossing mice bearing this transgene with mice that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under the control of a tissue-specific promoter permits regulation by tetracycline (or one of its derivatives) withdrawal/administration of the expression of H2-K1 in the progeny. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:205907)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:205907 Nagaraju K, et al., Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9209-14
• All: 6 reference(s)