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Gene Detail
histocompatibility 2, D region locus 1
STS D17Rua7
Synonyms H-2D
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.61 cM
Detailed Genetic Map ± 1 cM

Mapping data(59)
Sequence Map
Chr17:35262730-35267499 bp, + strand
From VEGA annotation of GRCm38

  4770 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-D1

Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
alleles, and
All mutations/alleles(5) : Spontaneous(2) Targeted(3)
Genomic Mutations involving H2-D1 (1)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a spontaneous allele are susceptible to chronic Theiler's Murine Encephalomyelitis Virus (TMEV) infection and demyelination, and lack the ability to respond to the viral peptide VP2121-130, the single Ag driving the protective CD8 T cell response in wild-type B6 mice.
H2-D1 interacts with 98 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (44 annotations)
Process antigen processing and presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
External Resources: FuncBase
Literature Summary: (8 records)
Data Summary: Results (103)    Tissues (77)    Images (5)
Theiler Stages: 1, 2, 3, 4, 15, 19, 20, 22, 23, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 24
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(115) Genomic(92) cDNA(18) Primer pair(4) Other(1)
Microarray probesets(11)
Other database
VEGA Gene ModelOTTMUSG00000037094 (Evidence)
Ensembl Gene ModelENSMUSG00000073411 (Evidence)
Entrez Gene14964 (Evidence)
PDB1BII, 1DDH, 1FFN, 1FFO, 1FFP, 1HOC, 1INQ, 1JPF, 1JPG, 1JUF, 1N3N, 1N5A, 1QLF, 1S7U, 1S7V, 1S7W, 1S7X, 1WBX, 1WBY, 1ZHB, 2CII, 2ZOK, 2ZOL, 3BUY, 3CCH, 3CPL, 3DMM, 3E6F, 3E6H, 3ECB, 3FTG, 3L3H, 3PQY, 3QUK, 3QUL, 3TBS, 3TBT, 3TBV, 3TBW, 3TBY, 4HUU, 4HUV, 4HUW, 4HUX, 4IHO, 4L8B, 4L8C, 4L8D, 4NSK, 1BZ9, 1CE6, 1FG2, 1QO3, 1YN6, 1YN7, 2F74, 2VE6, 3CC5, 3CH1, 3WS3, 3WS6, 4HV8
Consensus CDS ProjectCCDS57074.1
International Mouse Knockout Project StatusH2-D1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037094 VEGA Gene Model | MGI Sequence Detail 4770 C57BL/6J ±  kb
transcript OTTMUST00000095494 VEGA | MGI Sequence Detail 2102 Not Applicable 
polypeptide OTTMUSP00000053284 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(2) UniProt(28)
Polymorphisms RFLP(20) : SNPs within 2kb(184 from dbSNP Build 137)    SNPs within 2kb including multiple locations(188)
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR010579 MHC class I, alpha chain, C-terminal
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000002006 H-2 class I histocompatibility antigen D alpha chain
References (Earliest) J:106349 Melvold RW, et al., Eight new histocompatibility mutations associated with the H-2 complex. Immunogenetics. 1976;3:185-191
(Latest) J:208402 Chen X, et al., Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo. Lab Invest. 2014 May;94(5):478-90
All references(234)
accession IDs
MGD-MRK-10379, MGD-MRK-10492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory