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Gsta3 Gene Detail
Summary
  • Symbol
    Gsta3
  • Name
    glutathione S-transferase, alpha 3
  • Synonyms
    Gst2-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95856
    NCBI Gene: 14859
  • Gene Overview
    MyGene.info: GSTA3
Location & Maps
more
  • Sequence Map
    Chr1:21240589-21265661 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25073 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 6.50 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GSTA3, glutathione S-transferase alpha 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GSTA3, glutathione S-transferase alpha 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GSTA3-3, GTA3
  • Links
    NCBI Gene ID: 2940
    neXtProt AC: NX_Q16772

  • Chr Location
    6p12.1; chr6:52896639-52909798 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene does not alter viability, fertility or general health. However, adult homozygous mutant mice exhibit increased sensitivity to the acute cytotoxic and genotoxic effects of aflatoxin B1, a major risk factor for hepatocellular carcinoma in humans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026333 VEGA Gene Model | MGI Sequence Detail 25073 C57BL/6J ±  kb
transcript OTTMUST00000065121 VEGA | MGI Sequence Detail 1457 Not Applicable  
polypeptide OTTMUSP00000032414 VEGA | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    296 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR003080 Glutathione S-transferase, alpha class
    IPR004046 Glutathione S-transferase, C-terminal
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 162
    cDNA 161
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10310
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:11090 Kasahara M, et al., Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Genomics. 1990 Sep;8(1):90-6
  • Latest
    J:215356 Kensler KH, et al., Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci. 2014 Jun;139(2):293-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory