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Gsn
Gene Detail
Symbol

Name
ID
Gsn
gelsolin
MGI:95851
Feature Type
protein coding gene
Genetic Map
Chromosome 2
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:35279663-35307892 bp, + strand
From VEGA annotation of GRCm38

  28230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GSN
Protein SuperFamily: villin
Gene Tree: Gsn

Human
homologs
GSN, gelsolin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2934
neXtProt AC: NX_P06396

Human Synonyms: ADF, AGEL

Human Chr (Location): 9q33; chr9:121210803-121332844 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GSN

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Gsn interacts with 55 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process actin filament capping, actin filament polymerization, ...
Component actin cap, actin cytoskeleton, ...
Function actin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (271)    Tissues (220)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 169
Northern blot 17
Western blot 61
RT-PCR 12
cDNA source data(355)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GSN ; Xenbase gsn ; ZFIN gsna, gsnb    NEW 
Molecular
reagents
All nucleic(363) cDNA(356) Primer pair(6) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000012088 (Evidence)
Ensembl Gene Model ENSMUSG00000026879 (Evidence)
Entrez Gene 227753 (Evidence)
UniGene 21109
DFCI TC1573885, TC1695643, TC1696819
DoTS DT.101211313, DT.110710454, DT.110710557, DT.496424, DT.91394302, DT.91597065, DT.94204004, DT.97369681
NIA Mouse Gene Index U001654
PDB 1NPH, 4CBU, 4CBW, 4CBX
Consensus CDS Project CCDS15960.1
International Mouse Phenotyping Consortium Status Gsn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012088 VEGA Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
transcript OTTMUST00000028765 VEGA | MGI Sequence Detail 2653 Not Applicable 
polypeptide OTTMUSP00000013018 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(16) UniProt(6)
Polymorphisms
RFLP(3) : SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR007122 Villin/Gelsolin
Protein Ontology PR:000002202 gelsolin
References
(Earliest) J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
(Latest) J:212708 Olt J, et al., The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of Mammalian cochlear outer hair cells. PLoS One. 2014;9(1):e87331
All references(83)
Other
accession IDs
MGD-MRK-10302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory