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Gsn Gene Detail
Summary
  • Symbol
    Gsn
  • Name
    gelsolin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95851
    NCBI Gene: 227753
  • Gene Overview
    MyGene.info: GSN
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:35256380-35307892 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 23.50 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95851
protein coding gene Chr2:35256359-35307902 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025651
protein coding gene Chr2:33886862-33939440 (+)
A/J MGP_AJ_G0025628
protein coding gene Chr2:32451709-32503202 (+)
AKR/J MGP_AKRJ_G0025598
protein coding gene Chr2:33593690-33645182 (+)
BALB/cJ MGP_BALBcJ_G0025625
protein coding gene Chr2:32560447-32611973 (+)
C3H/HeJ MGP_C3HHeJ_G0025385
protein coding gene Chr2:33485900-33537383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026069
protein coding gene Chr2:34862975-34916691 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023478
protein coding gene Chr2:31134631-31186679 (+)
CAST/EiJ MGP_CASTEiJ_G0024847
protein coding gene Chr2:33477724-33529209 (+)
CBA/J MGP_CBAJ_G0025363
protein coding gene Chr2:36207721-36260598 (+)
DBA/2J MGP_DBA2J_G0025496
protein coding gene Chr2:32216653-32267961 (+)
FVB/NJ MGP_FVBNJ_G0025458
protein coding gene Chr2:32113664-32165157 (+)
LP/J MGP_LPJ_G0025582
protein coding gene Chr2:33814800-33866116 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025489
protein coding gene Chr2:35716246-35767569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026127
protein coding gene Chr2:33479584-33531007 (+)
PWK/PhJ MGP_PWKPhJ_G0024595
protein coding gene Chr2:32130223-32182377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024395
protein coding gene Chr2:33644264-33698101 (+)
WSB/EiJ MGP_WSBEiJ_G0024916
protein coding gene Chr2:33662529-33713897 (+)



Homology
more
  • Human Ortholog
    GSN, gelsolin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSN, gelsolin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADF, AGEL
  • Links
    NCBI Gene ID: 2934
    neXtProt AC: NX_P06396
    UniProt: P06396

  • Chr Location
    9q33.2; chr9:121201082-121332844 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 147
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSN
  • Protein SuperFamily
  • Gene Tree
    Gsn
Human Diseases
more
  • Diseases
    1 with human GSN associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026879 Ensembl Gene Model | MGI Sequence Detail 51513 C57BL/6J ±  kb
    transcript ENSMUST00000028239 Ensembl | MGI Sequence Detail 2653 Not Applicable  
    polypeptide ENSMUSP00000028239 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 364
      cDNA 357
      Primer pair 6
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10302
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
    • Latest
      J:269086 Gertz K, et al., The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Exp Neurol. 2018 Aug;306:34-44

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/05/2019
    MGI 6.14
    The Jackson Laboratory