Gsn
Gene Detail

Symbol Name ID

Gsn gelsolin MGI:95851

Feature Type

protein coding gene

Genetic Map

Chromosome 2

23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr2:35279663-35307892 bp, + strand From VEGA annotation of GRCm38   28230 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Gsn ± 2 cM)

Protein SuperFamily: villin
Gene Tree: Gsn

Human ortholog

GSN gelsolin NCBI Gene ID 2934
Human Synonyms: ADF, AGEL
Human Chr9:124030380-124095120 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GSN (1)

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	actin filament capping, actin filament polymerization, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	actin binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (228)    Tissues (180)    Images (31)
Theiler Stages: 11, 12, 13, 16, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	133
Northern blot	17
Western blot	61
RT-PCR	5

cDNA source data(355)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(361) cDNA(356) Primer pair(4) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000012088 (Evidence)
Ensembl Gene Model	ENSMUSG00000026879 (Evidence)
Entrez Gene	227753 (Evidence)
UniGene	21109
DFCI	TC1573885, TC1695643, TC1696819
DoTS	DT.101211313, DT.110710454, DT.110710557, DT.496424, DT.91394302, DT.91597065, DT.94204004, DT.97369681
NIA Mouse Gene Index	U001654
PDB	1NPH
Consensus CDS Project	CCDS15960.1
International Mouse Knockout Project Status	Gsn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012088	VEGA Gene Model | MGI Sequence Detail	28230	C57BL/6J
transcript	OTTMUST00000028765	VEGA | MGI Sequence Detail	2653	Not Applicable
polypeptide	OTTMUSP00000013018	VEGA | MGI Sequence Detail	780	Not Applicable

All sequences(96) RefSeq(8) UniProt(7)

Polymorphisms

RFLP(3) : SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007122	Gelsolin
InterPro	IPR007123	Gelsolin domain
Protein Ontology	PR:000002202	gelsolin

References

(Earliest) J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
(Latest) J:189076 Godin JD, et al., p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Dev Cell. 2012 Oct 16;23(4):729-44
All references(76)

Other accession IDs

MGD-MRK-10302