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Gsn Gene Detail
Summary
  • Symbol
    Gsn
  • Name
    gelsolin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95851
    NCBI Gene: 227753
  • Gene Overview
    MyGene.info: GSN
Location & Maps
more
  • Sequence Map
    Chr2:35256380-35307892 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51513 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 23.50 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    GSN, gelsolin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSN, gelsolin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADF, AGEL
  • Links
    NCBI Gene ID: 2934
    neXtProt AC: NX_P06396

  • Chr Location
    9q33; chr9:121210803-121332844 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 147
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GSN
  • Protein SuperFamily
  • Gene Tree
    Gsn
Human Diseases
more
  • Diseases
    1 with human GSN associations

Human Disease Mouse Models
       Amyloidosis, Finnish Type   OMIM: 105120 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012088 VEGA Gene Model | MGI Sequence Detail 51513 C57BL/6J ±  kb
transcript OTTMUST00000028765 VEGA | MGI Sequence Detail 2653 Not Applicable  
polypeptide OTTMUSP00000013018 VEGA | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    232 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 363
    cDNA 356
    Primer pair 6
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10302
References
more
  • Summaries
    All 82
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 8
    Phenotypes 25
  • Earliest
    J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
  • Latest
    J:212708 Olt J, et al., The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of Mammalian cochlear outer hair cells. PLoS One. 2014;9(1):e87331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory