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Gsn
Gene Detail
 Symbol
Name
ID
Gsn
gelsolin
MGI:95851
Feature Type protein coding gene
Genetic Map
Chromosome 2
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:35279663-35307892 bp, + strand
From VEGA annotation of GRCm38

  28230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: villin
Gene Tree: Gsn

Human
homologs
Human Homolog GSN, gelsolin
NCBI Gene ID 2934
neXtProt AC  NX_P06396
Human Synonyms  ADF, AGEL
Human Chr (Location)  9q33; chr9:121268102-121332844 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GSN
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actin filament capping, actin filament polymerization, ...
Component actin cytoskeleton, blood microparticle, ...
Function actin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (259)    Tissues (208)    Images (33)
Theiler Stages: 11, 12, 13, 16, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 164
Northern blot 17
Western blot 61
RT-PCR 5
cDNA source data(354)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(360) cDNA(355) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000012088 (Evidence)
Ensembl Gene ModelENSMUSG00000026879 (Evidence)
Entrez Gene227753 (Evidence)
UniGene21109
DFCITC1573885, TC1695643, TC1696819
DoTSDT.101211313, DT.110710454, DT.110710557, DT.496424, DT.91394302, DT.91597065, DT.94204004, DT.97369681
NIA Mouse Gene IndexU001654
PDB1NPH
Consensus CDS ProjectCCDS15960.1
International Mouse Knockout Project StatusGsn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012088 VEGA Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
transcript OTTMUST00000028765 VEGA | MGI Sequence Detail 2653 Not Applicable 
polypeptide OTTMUSP00000013018 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(16) UniProt(6)
Polymorphisms RFLP(3) : SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR007122 Villin/Gelsolin
Protein Ontology PR:000002202 gelsolin
References (Earliest) J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
(Latest) J:204969 Kim H, et al., Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-beta1. J Biol Chem. 2013 Nov 29;288(48):34352-63
All references(80)
Other
accession IDs
MGD-MRK-10302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory