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Gsx2
Gene Detail
Symbol

Name
ID
Gsx2
GS homeobox 2
MGI:95843
Synonyms
Gsh2, Gsh-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:75075464-75077893 bp, + strand
From VEGA annotation of GRCm38

  2430 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gsx2

Human
homologs
Human Homolog GSX2, GS homeobox 2
NCBI Gene ID 170825
neXtProt AC  NX_Q9BZM3
Human Synonyms  GSH2
Human Chr (Location)  4q12; chr4:54100081-54101955 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation die within 24 hrs after birth, displaying an early misspecification of precursors in the lateral ganglionic eminence that leads to disruptions in striatal and olfactory bulb development.
 
Interactions
Gsx2 interacts with 99 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, central nervous system development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (84 records)
Data Summary: Results (197)    Tissues (83)    Images (87)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 111
Northern blot 1
RT-PCR 41
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(11) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024574 (Evidence)
Ensembl Gene ModelENSMUSG00000035946 (Evidence)
Entrez Gene14843 (Evidence)
UniGene218752
DFCITC1591733
DoTSDT.97403916
NIA Mouse Gene IndexU005694
Consensus CDS ProjectCCDS19350.1
International Mouse Knockout Project StatusGsx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024574 VEGA Gene Model | MGI Sequence Detail 2430 C57BL/6J ±  kb
transcript OTTMUST00000060364 VEGA | MGI Sequence Detail 1665 Not Applicable 
polypeptide OTTMUSP00000029444 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008309 GS homeobox 2
References
(Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:201994 Ehrman LA, et al., The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4026-35
All references(123)
Other
accession IDs
MGD-MRK-10285, MGD-MRK-10290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory