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Gsx2
Gene Detail
Symbol

Name
ID
Gsx2
GS homeobox 2
MGI:95843
Synonyms
Gsh2, Gsh-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
39.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:75075464-75077893 bp, + strand
From VEGA annotation of GRCm38

  2430 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15377  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GSX2
Gene Tree: Gsx2

Human
homologs
GSX2, GS homeobox 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 170825
neXtProt AC: NX_Q9BZM3

Human Synonyms: GSH2

Human Chr (Location): 4q12; chr4:54100081-54101955 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Gsx2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation die within 24 hrs after birth, displaying an early misspecification of precursors in the lateral ganglionic eminence that leads to disruptions in striatal and olfactory bulb development.
 
Phenotype Images(4)
Interactions
Gsx2 interacts with 99 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process brain development, central nervous system development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (197)    Tissues (83)    Images (87)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 111
Northern blot 1
RT-PCR 41
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gsx2    NEW 
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(11) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024574 (Evidence)
Ensembl Gene Model ENSMUSG00000035946 (Evidence)
Entrez Gene 14843 (Evidence)
UniGene 218752
DFCI TC1591733
DoTS DT.97403916
NIA Mouse Gene Index U005694
Consensus CDS Project CCDS19350.1
International Mouse Phenotyping Consortium Status Gsx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024574 VEGA Gene Model | MGI Sequence Detail 2430 C57BL/6J ±  kb
transcript OTTMUST00000060364 VEGA | MGI Sequence Detail 1665 Not Applicable 
polypeptide OTTMUSP00000029444 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008309 GS homeobox 2
References
(Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(123)
Other
accession IDs
MGD-MRK-10285, MGD-MRK-10290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory