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Gsx2 Gene Detail
Summary
  • Symbol
    Gsx2
  • Name
    GS homeobox 2
  • Synonyms
    Gsh2, Gsh-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95843
    NCBI Gene: 14843
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:75075601-75077893 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 39.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95843
protein coding gene Chr5:75075601-75077893 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029636
protein coding gene Chr5:75186261-75188553 (+)
A/J MGP_AJ_G0029604
protein coding gene Chr5:72331359-72333651 (+)
AKR/J MGP_AKRJ_G0029552
protein coding gene Chr5:74687489-74689781 (+)
BALB/cJ MGP_BALBcJ_G0029613
protein coding gene Chr5:73041161-73043453 (+)
C3H/HeJ MGP_C3HHeJ_G0029336
protein coding gene Chr5:75073627-75075919 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030067
protein coding gene Chr5:78214629-78216921 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027307
protein coding gene Chr5:68007024-68009360 (+)
CAST/EiJ MGP_CASTEiJ_G0028744
protein coding gene Chr5:74187743-74190035 (+)
CBA/J MGP_CBAJ_G0029305
protein coding gene Chr5:80805464-80807756 (+)
DBA/2J MGP_DBA2J_G0029450
protein coding gene Chr5:72412866-72415158 (+)
FVB/NJ MGP_FVBNJ_G0029411
protein coding gene Chr5:71565786-71568078 (+)
LP/J MGP_LPJ_G0029536
protein coding gene Chr5:75613332-75615624 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029438
protein coding gene Chr5:84017567-84019859 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030100
protein coding gene Chr5:74221327-74223619 (+)
PWK/PhJ MGP_PWKPhJ_G0028467
protein coding gene Chr5:71403914-71406206 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028302
protein coding gene Chr5:73580757-73583053 (+)
WSB/EiJ MGP_WSBEiJ_G0028824
protein coding gene Chr5:74512883-74515175 (+)



Homology
more
  • Human Ortholog
    GSX2, GS homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSX2, GS homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DMJDS2, GSH2
  • Links
    NCBI Gene ID: 170825
    neXtProt AC: NX_Q9BZM3
    UniProt: Q9BZM3

  • Chr Location
    4q12; chr4:54100081-54101955 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15377
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSX2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    309 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation die within 24 hrs after birth, displaying an early misspecification of precursors in the lateral ganglionic eminence that leads to disruptions in striatal and olfactory bulb development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14843 NCBI Gene Model | MGI Sequence Detail 2293 C57BL/6J ±  kb
    transcript NM_133256 RefSeq | MGI Sequence Detail 1665 C57BL/6  
    polypeptide P31316 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 12
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10285, MGD-MRK-10290
    References
    more
    • Summaries
      All 425
      Developmental Gene Expression 110
      Diseases 1
      Gene Ontology 14
      Phenotypes 309
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:280568 Zhang X, et al., Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Rep. 2019 Jul 16;28(3):792-803.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory