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Gsc
Gene Detail
Symbol

Name
ID
Gsc
goosecoid homeobox
MGI:95841
Feature Type
protein coding gene
Genetic Map
Chromosome 12
54.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:104471209-104473330 bp, - strand
From VEGA annotation of GRCm38

  2122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GSC
Protein SuperFamily: homeotic protein goosecoid
Gene Tree: Gsc

Human
homologs
GSC, goosecoid homeobox
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 145258
neXtProt AC: NX_P56915

Human Synonyms: SAMS

Human Chr (Location): 14q32.1; chr14:94768223-94770162 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GSC

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit craniofacial abnormalities affecting the mandible, nasal cavities and pits, tongue, and inner ear, and skeletal defects involving ribs, sternum, shoulder and hip. Mutants die neonatally.
 
Interactions
Gsc interacts with 51 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anatomical structure morphogenesis, dorsal/ventral neural tube patterning, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (134 records)
Data Summary: Results (617)    Tissues (308)    Images (174)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 496
In situ reporter (knock in) 58
RT-PCR 52
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GSC ; Xenbase gsc ; ZFIN gsc    NEW 
Molecular
reagents
All nucleic(36) Genomic(7) cDNA(15) Primer pair(5) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021487 (Evidence)
Ensembl Gene Model ENSMUSG00000021095 (Evidence)
Entrez Gene 14836 (Evidence)
UniGene 129
DFCI TC1589603
DoTS DT.40136757
NIA Mouse Gene Index U034306
Consensus CDS Project CCDS26153.1
International Mouse Phenotyping Consortium Status Gsc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021487 VEGA Gene Model | MGI Sequence Detail 2122 C57BL/6J ±  kb
transcript OTTMUST00000050923 VEGA | MGI Sequence Detail 1268 Not Applicable 
polypeptide OTTMUSP00000023890 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008278 homeobox protein goosecoid
References
(Earliest) J:1337 Blum M, et al., Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell. 1992 Jun 26;69(7):1097-106
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(180)
Other
accession IDs
MGD-MRK-10283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory