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Gsc
Gene Detail
 Symbol
Name
ID
Gsc
goosecoid homeobox
MGI:95841
Feature Type protein coding gene
Genetic Map
Chromosome 12
54.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:104471210-104473324 bp, - strand
From VEGA annotation of GRCm38

  2115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein goosecoid
Gene Tree: Gsc

Human
homologs
Human Homolog GSC, goosecoid homeobox
NCBI Gene ID 145258
neXtProt AC  NX_P56915
Human Synonyms  SAMS
Human Chr (Location)  14q32.1; chr14:94768223-94770162 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GSC
Alleles
and
phenotypes
All alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit craniofacial abnormalities affecting the mandible, nasal cavities and pits, tongue, and inner ear, and skeletal defects involving ribs, sternum, shoulder and hip. Mutants die neonatally.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anatomical structure morphogenesis, dorsal/ventral neural tube patterning, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (127 records)
Data Summary: Results (616)    Tissues (308)    Images (166)
Theiler Stages: 2, 3, 4, 5, 7, 9, 10, 11, 12, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 488
In situ reporter (knock in) 58
RT-PCR 59
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(7) cDNA(15) Primer pair(5) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021487 (Evidence)
Ensembl Gene ModelENSMUSG00000021095 (Evidence)
Entrez Gene14836 (Evidence)
UniGene129
DFCITC1589603
DoTSDT.40136757
NIA Mouse Gene IndexU034306
Consensus CDS ProjectCCDS26153.1
International Mouse Knockout Project StatusGsc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021487 VEGA Gene Model | MGI Sequence Detail 2115 C57BL/6J ±  kb
transcript OTTMUST00000050923 VEGA | MGI Sequence Detail 1261 Not Applicable 
polypeptide OTTMUSP00000023890 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008278 homeobox protein goosecoid
References (Earliest) J:1337 Blum M, et al., Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell. 1992 Jun 26;69(7):1097-106
(Latest) J:206666 Parry DA, et al., SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. Am J Hum Genet. 2013 Dec 5;93(6):1135-42
All references(176)
Other
accession IDs
MGD-MRK-10283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory